Maternal red blood cell alloimmunisation Working Party, literature review. RH blood group system: Rare specificities

Floch, Aline

doi:10.1016/j.tracli.2021.04.007

Cited by 7 publications

(11 citation statements)

References 63 publications

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“…The sample size was calculated using an online calculator, with the jaundice prevalence in neonates of 80%, as reported in literature. 11 Inclusion Criteria: All neonates born to mothers having RhD negative and 'O' blood groups were included.…”

Section: Methodsmentioning

confidence: 99%

Utility of Direct Coomb’s test in a Tertiary Care Nursery

Ahmed,

Anwar,

Gul

et al. 2023

PAFMJ

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Objective: To document the causes and clinical significance of direct Coomb’s test distal convoluted tubule in neonatal Jaundice at a tertiary care setup. Study Design: Cross-sectional study. Place and Duration of the Study: Fatima Memorial Hospital, Lahore Pakistan, from Nov 2019 to Oct 2020. Methodology: All babies born to “O” or Rh-negative blood group mothers were included. In addition, data including demographics, mother’s blood group, baby’s blood group, direct Coomb’s test results, bilirubin values, and need for treatment was recorded. Results: The study included 989 neonates. Of all, 489(49.4%) were male, the mean birth weight was 2.80±0.75 kg, and the mean gestation was 36±4.3 weeks. ABO mismatch was present in 452(45.7%) cases and Rh mismatch in 123(12.4%). Of all, 58(5.9%) had positive direct Coomb’s test. Amongst the positive direct Coomb’s test patients, 44(75.8%) babies needed treatment, of which 40(90.9%) received phototherapy, and 4(6.8%) needed Intensive phototherapy (360 degrees). No baby needed an exchange transfusion. Conclusion: In most cases, positive direct Coomb’s test was due to ABO blood group incompatibility. In addition, early phototherapy can control bilirubin rise in most cases, so few would need aggressive or intensive treatment.Keywords: ABO mismatch, Direct Coomb’s test, Neonatal jaundice, Rh mismatch.

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Section: Methodsmentioning

confidence: 99%

Utility of Direct Coomb’s test in a Tertiary Care Nursery

Ahmed,

Anwar,

Gul

et al. 2023

PAFMJ

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“…» Anti-D und Anti-Kell sind hoch immunogen und können schwere hämolytische Verläufe verursachen Anti-Dund Anti-Kell besitzeneinehoheImmunogenität und können sehr schwere hämolytische Verläufe bei Feten verursachen [18]. Durch Bindung der AK an die entsprechenden Erythrozytenantigene des Feten kommt es zu einer immunkomplexvermit-…”

Section: Ursachen Für Eine Alloimmunisierungunclassified

Screening auf irreguläre mütterliche Blutgruppenantikörper und fetale Blutgruppenbestimmung

Kapfhammer¹,

Ochsenbein‐Kölble²

2023

Gynäkologie

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ZusammenfassungEine Alloimmunisierung aufgrund einer Blutgruppeninkompatibilität, insbesondere des Rhesusgens, ist eine seltene, meist schwerwiegende Komplikation in der Schwangerschaft, die unbehandelt zum intrauterinen Fruchttod führen kann. Bereits im ersten Trimenon sollten daher eine Blutgruppenbestimmung und ein Antikörpersuchtest durchgeführt werden. Ziel dieser Screeninguntersuchung ist es, Risikoschwangerschaften aufgrund mütterlicher irregulärer Antikörper frühzeitig zu erkennen. Durch die Einführung der standardisierten prä- und postpartalen Anti-D-Immunprophylaxe bei Rh(Rhesus)D-negativen Schwangeren konnte die RhD-Alloimmunisierung deutlich gesenkt werden. Inzwischen bietet zudem die nichtinvasive Testung an „cell free fetal DNA“ im mütterlichen Blut die Möglichkeit, fetale Rh-Antigene bereits präpartal zu bestimmen. Dadurch eröffnet sich die Möglichkeit, das Risikokollektiv weiter einzugrenzen und selektiv eine gezielte Anti-D-Immunprophylaxe anzubieten. Bei positivem fetalem Rh-D-Nachweis wird bei RhD-negativen Schwangeren in der Regel bei 28–30 Schwangerschaftswochen eine Anti-D-Immunprophylaxe verabreicht. Hat trotzdem eine Alloimmunisierung mit erhöhtem Risiko für eine fetale Anämie stattgefunden, ist eine Zuweisung in ein Perinatalzentrum oder zu einen fetomaternalen Spezialisten indiziert. Bei Verdacht auf eine fetale Anämie kann eine fetale Bluttransfusion per Nabelschnurpunktion lebensrettend sein.

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“…Partial D may show variable serological reactivity. In some cases with positive reactivity rather than weak positive reactivity on RhD typing, it is difficult to detect partial D unless the individual has been exposed to D antigens, resulting in anti-D formation [ 3 , 4 ]. Among various partial D alleles, RHD*DNT ( RHD*38 ) shows a single missense variant in exon 3, namely c.455A>C (N152T) [ 5 ].…”

mentioning

confidence: 99%

“…The 20 RHD alleles harboring c.455A>C (N152T) are listed in Table 2 [ 3 - 5 , 8 ]. The designation RHD*DNT was derived from the asparagine (N) to threonine (T) amino acid substitution, and N152T has been suggested to cause a high D antigen density (>20,000 antigens per red blood cell) by facilitating the integration of the RhD protein into the red blood cell membrane.…”

mentioning

confidence: 99%

“…Although further research is required to define the underlying mechanism and to investigate the relationship between the increased antigen density and epitope change, it is assumed that the internally located N152T substitution (in the transmembrane zone) may alter extracellular epitopes. Among the 20 alleles harboring N152T, 11 alleles have been associated with anti-D formation [ 3 , 4 ]; RHD alleles harboring N152T do not necessarily imply anti-D formation, and conversely, any alleles harboring N152T may have the potential to form anti-D. In RhD-positive individuals with anti-D formation, Sanger sequencing of the RHD exons can help clinically differentiate the RHD alleles harboring N152T.…”

mentioning

confidence: 99%

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RHDDNT* (RHD38*) Showing D-Positive Reactivity on Rhesus D Typing and Forming Anti-D Antibody

et al. 2023

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Maternal red blood cell alloimmunisation Working Party, literature review. RH blood group system: Rare specificities

Cited by 7 publications

References 63 publications

Utility of Direct Coomb’s test in a Tertiary Care Nursery

Utility of Direct Coomb’s test in a Tertiary Care Nursery

Screening auf irreguläre mütterliche Blutgruppenantikörper und fetale Blutgruppenbestimmung

RHDDNT* (RHD38*) Showing D-Positive Reactivity on Rhesus D Typing and Forming Anti-D Antibody

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Maternal red blood cell alloimmunisation Working Party, literature review. RH blood group system: Rare specificities

Cited by 7 publications

References 63 publications

Utility of Direct Coomb’s test in a Tertiary Care Nursery

Utility of Direct Coomb’s test in a Tertiary Care Nursery

Screening auf irreguläre mütterliche Blutgruppenantikörper und fetale Blutgruppenbestimmung

RHD*DNT (RHD*38) Showing D-Positive Reactivity on Rhesus D Typing and Forming Anti-D Antibody

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RHDDNT* (RHD38*) Showing D-Positive Reactivity on Rhesus D Typing and Forming Anti-D Antibody