Maternal Residential Exposure to Hazardous Wastes and Risk of Central Nervous System and Musculoskeletal Birth Defects

Abstract

The authors used a case-control design to evaluate the risk of central nervous system and musculoskeletal birth defects relative to exposure to solvents, metal, and pesticide contaminants from hazardous waste sites. Cases included 473 central-nervous-system-defect births and 3305 musculoskeletal-defect births to residents of 18 counties in New York State; controls comprised 12,436 randomly chosen normal births. For each address at birth, the authors assigned a probability of exposure to solvents, metals, and pesticides from hazardous waste sites in the study area (n = 643). They also rated residences by proximity to air releases from industrial facilities and by contamination of community water supplies. Compared with individuals for whom a low probability of exposure existed, mothers who resided in areas assigned a medium or high probability of exposure to hazardous waste contaminants did not show an increased risk of either type of birth defects. After adjusting for mother's race and age, prenatal care initiation, and population density, the resulting relative risks were as follows: central nervous system defects and exposure to solvents, 0.8 (95% confidence interval [CI] = .4, .6); central nervous system and metals, 1.0 (95% CI = 0.7, 1.7); musculoskeletal defects and solvents, 0.9 (95% CI = 0.5, 1.3); and musculoskeletal defects and pesticides, .8 (95% CI = .5, 1.3). With respect to central nervous system defects, there was an elevated risk associated with living near industrial facilities that emitted solvents (odds ratio = 1.3 [95% CI = 1.0, 1.7]) or metals (OR = 1.4, [95% CI = 1.0, 1.8]) into the air. The low proportion of individuals who had a medium or high probability of residential exposure to hazardous waste-site contaminants limited the investigation of particular pathways, disease subgroups, and/or geographic areas. Associations between central nervous system defects and industrial releases of solvents and metals need to be investigated further.

Incidence of endocrine disease among residents of New York areas of concern.

“…However, Stehr-Green et al (13) reported that people living near waste sites had a higher average serum PCB level, and a greater percentage had PCB levels elevated with respect to the average U.S. level. Geschwind et al (14) and Dolk et al (15) have both reported elevated incidence of birth defects in individuals living near hazardous waste sites, but other studies have not seen this relationship (16).…”

Health effects of residence near hazardous waste landfill sites: a review of epidemiologic literature.

“…A dose-response relationship (higher risks with higher exposure) was reported between estimated hazard potential of the site and risk of malformation, adding support to a possible causal relationship. However, a follow-up study of Geschwind's findings (62) found no relation between two selected types of malformations (central nervous system and musculoskeletal) and living near a hazardous waste disposal site. The study did report an increased risk of central nervous system defects for those living near solvent-or metalemitting industrial facilities.…”

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

“…ambient air monitoring) have been linked to live birth registries to assess the impact of air pollution on infant birth size (Wilhelm & Ritz, 2003), gestation (Ritz et al, 2000), or birth defects (Ritz et al, 2002). Similarly, geographic proximity to hazardous waste sites (Marshall et al, 1997) and the consumption of PCB-contaminated fish (Mendola et al, 2005) have been associated with birth defects using a state birth defects registry.…”