Maternal Screening and Treatment for Group B Streptococcus

James, Dotti C.

doi:10.1111/j.1552-6909.2001.tb00013.x

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…For the animal strains of the GBS, the phenomenon of the resistance to antibiotics is more often met than in human strains [29]. β-lactam antibiotics are one of the oldest and most prescribed classes of antibacterial treatments worldwide [30], which is widely used in GBS treatment [31,32,33,34]. We have shown that Opp (oppA1, oppA2, oppB, oppC, oppD and oppF) and PBP1a (mrcA) encoding genes were significant down-regulated in YM001, which were regulating the β-lactam antibiotics resistance of the GBS.…”

Section: Discussionmentioning

confidence: 99%

The Interaction between Phagocytes and Streptococcus agalactiae (GBS) Mediated by the Activated Complement System is the Key to GBS Inducing Acute Bacterial Meningitis of Tilapia

Liu

Huang

et al. 2019

Animals

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Simple SummaryStreptococcus agalactiae (GBS) is a serious threat to farmed tilapia, which results in high mortality and seriously hinders tilapia farming development. The pathogenic mechanism of tilapia infected with GBS which die rapidly in production remains unknown. We provided a comprehensive comparative analysis of the tilapias infected with fish-derived GBS attenuated strain YM001 and its parental virulent strain HN016. The present study indicates that the interaction between phagocytes and GBS mediated by the activated complement system is key to GBS inducing tilapia acute bacterial meningitis. The low survival ability caused by reduced β-lactam antibiotics resistance is one of the important reasons YM001 lost its pathogenicity to tilapia. Our study provided a comprehensive cognition of the mechanism of acute bacterial meningitis caused by GBS.AbstractStreptococcus agalactiae is an important pathogen for tilapia meningitis. Most of the infected tilapia die rapidly in production, when the way to study the pathogenic mechanism of bacteria on host through chronic infection in laboratory is not comprehensive and accurate enough to elucidate the real pathogenic mechanism. The objective of this study was to investigate the mechanism of acute bacterial meningitis of tilapia caused by Streptococcus agalactiae (GBS), and provide a theoretical basis for its prevention and treatment. Duel RNA-seq, proteome analysis, histopathological analysis, plasma biochemical indexes, and blood routine examination were performed on tilapias infected with fish-derived GBS attenuated strain YM001 and its parental virulent strain HN016. The results showed that the contents of white blood cell (WBC), monocytes (MON), and neutrophil (NEU) were significantly lower in the HN016 group compared to that in the YM001 group (p < 0.05). Histopathological examination showed that there were partially lesions in the examined tissues of tilapia infected by HN016, while no obvious histopathological changes occurred in the YM001 group. The differential expressed genes (DEGs) and differential expressed proteins (DEPs) between YM001 and HN016 were mainly enriched in the beta-lactam resistance pathway (oppA1, oppA2, oppB, oppC, oppD, oppF, and mrcA). The DEGs DEPs between YM001-brain and HN016-brain were mainly enriched in the complement and coagulation cascades signaling pathway (C2a, c4b, c3b, c7, CD59, ITGB2, and ITGAX). The present study indicates that the interaction between phagocytes and GBS mediated by the activated complement system is the key to GBS inducing tilapia acute bacterial meningitis. The low survival ability caused by reduced β-lactam antibiotics resistance is one of the important reasons for why YM001 lost its pathogenicity to tilapia.

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Section: Discussionmentioning

confidence: 99%

The Interaction between Phagocytes and Streptococcus agalactiae (GBS) Mediated by the Activated Complement System is the Key to GBS Inducing Acute Bacterial Meningitis of Tilapia

Liu

Huang

et al. 2019

Animals

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Pilot Study to Prevent Early-Onset Group B Streptococcal Disease in Newborns

Jefferson¹

2006

Advances in Neonatal Care

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There were no differences found in the incidence of early-onset GBS disease in newborns when a GBS positive pregnant woman received 1 or 2 doses of intrapartum antibiotics. These data provide further supporting evidence for the Centers for Disease Control and Prevention's recommendations that were based on the premise that vertical transmission of GBS will be greatly reduced by administration of 1 dose of intrapartum antibiotics at least 4 hours before delivery to expectant mothers.

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The Relationship Between Abuse, Sexually Transmitted Diseases, & Group B Streptococcus in Childbearing Women

Winn

Records²,

Rice³

2003

MCN, The American Journal of Maternal/Child Nursing

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The findings support previously published results that abuse is widespread in the United States and that abused women are at increased risk for STDs. These results highlight the need for regular screenings for abuse during healthcare, for abuse is a critical variable to consider when screening for STDs and GBS. STD screening typically occurs during the first prenatal visit and may need to be repeated for high-risk groups.

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Maternal Screening and Treatment for Group B Streptococcus

Cited by 3 publications

References 32 publications

The Interaction between Phagocytes and Streptococcus agalactiae (GBS) Mediated by the Activated Complement System is the Key to GBS Inducing Acute Bacterial Meningitis of Tilapia

The Interaction between Phagocytes and Streptococcus agalactiae (GBS) Mediated by the Activated Complement System is the Key to GBS Inducing Acute Bacterial Meningitis of Tilapia

Pilot Study to Prevent Early-Onset Group B Streptococcal Disease in Newborns

The Relationship Between Abuse, Sexually Transmitted Diseases, & Group B Streptococcus in Childbearing Women

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