Maternal separation alters drug intake patterns in adulthood in rats

Moffett, MC; Vicentic, Aleksandra; Kozel, Marie; Plotsky, Paul M.; Francis, Darlene D.; Kuhar, Michael J.

doi:10.1016/j.bcp.2006.08.003

Cited by 177 publications

(140 citation statements)

References 123 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…The present study replicated our previous findings of ELS-induced increases in METH SA (Lewis et al, 2013;Lewis et al, 2015), which is also consistent with other drugs of abuse (Vazquez et al, 2005;Moffett et al, 2007). We also present novel findings that ELS alone increases MeCP2 expression in the NAc core, but not the NAc shell or the dorsal striatum.…”

Section: Discussionsupporting

confidence: 92%

Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats

Lewis

Bastle

Manning

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

Early life stress (ELS) is highly related to the development of psychiatric illnesses in adulthood, including substance use disorders. A recent body of literature suggests that long-lasting changes in the epigenome may be a mechanism by which experiences early in life can alter neurobiological and behavioral phenotypes in adulthood. In this study, we replicate our previous findings that ELS, in the form of prolonged maternal separation, increases adult methamphetamine self-administration (SA) in male rats as compared with handled controls. In addition, we show new evidence that both ELS and methamphetamine SA alter the expression of the epigenetic regulator methyl CpGbinding protein 2 (MeCP2) in key brain reward regions, particularly in the nucleus accumbens (NAc) core. In turn, viral-mediated knockdown of MeCP2 expression in the NAc core reduces methamphetamine SA, as well as saccharin intake. Furthermore, NAc core MeCP2 knockdown reduces methamphetamine, but not saccharin, SA on a progressive ratio schedule of reinforcement. These data suggest that NAc core MeCP2 may be recruited by both ELS and methamphetamine SA and promote the development of certain aspects of drug abuse-related behavior. Taken together, functional interactions between ELS, methamphetamine SA, and the expression of MeCP2 in the NAc may represent novel mechanisms that can ultimately be targeted for intervention in individuals with adverse early life experiences who are at risk for developing substance use disorders.

show abstract

Section: Discussionsupporting

confidence: 92%

Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats

Lewis

Bastle

Manning

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The amphetamine self-administration paradigm used in this study has been employed previously to investigate individual differences in increased responding to psychostimulants (Cain et al, 2008) and its association with increased addiction risk. Therefore, the results from this study are in agreement with previous animal and clinical studies demonstrating that PSE leads to increased addiction risk and associated behavioral phenotypes (Charmandari et al, 2003;Deminiere et al, 1992;Kippin et al, 2008;Moffett et al, 2007;Thomas et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

Prenatal Stress Exposure Increases the Excitation of Dopamine Neurons in the Ventral Tegmental Area and Alters Their Reponses to Psychostimulants

Hausknecht

Haj‐Dahmane

Shen

2012

Neuropsychopharmacol

View full text Add to dashboard Cite

Prenatal stress exposure (PSE) is known to increase addiction risk. Dopamine (DA) neurons in the ventral tegmental area (VTA) play an important role in addiction. In order to understand the cellular mechanisms underlying PSE-induced increase in addiction risk, we examined the effects of PSE on the electrical impulse activity of VTA DA neurons using the in vivo extracellular single-unit recording technique. Amphetamine self-administration was also conducted to confirm increased addiction risk after PSE. The PSE was carried out by restraining pregnant dams from GD 11 to 20. Adult male offspring (3-6 months old) were used in the experiments. Animals with PSE showed enhanced amphetamine self-administration compared with controls when amphetamine dose was reduced after acquisition. The number of spontaneously active VTA DA neurons was also reduced in PSE rats. The reduction was reversed by acute apomorphine that normally inhibits the impulse activity of DA neurons. The reversal effect suggests that PSE-induced reduction in the number of spontaneously active VTA DA neurons is caused by overexcitation to the extent of depolarization block. Furthermore, the reduced number of spontaneously active VTA DA neurons was also reversed by acute psychostimulants (eg, amphetamine; cocaine), which in control rats inhibited the activity of VTA DA neurons. The reversal effect on VTA DA neuron in PSE animals represents an actual increase in the impulse activity. This effect might contribute to increased responding to psychostimulants and mediate increased addiction risk after PSE.

show abstract

“…In the MS paradigm, pups are separated from the dams for between 15 minutes and 6 hours daily, during the first two weeks of life. 158 In normal rats, this results in the development of neurochemical and behavioural changes expressed even in adulthood, such as increased anxiety and stress-reactivity (reviewed by Holmes et al 159 ). It was presumed that exposing the rats with a genetic predisposition for the development of depressive phenotype, such as FSL, to maternal separation, would model the gene-environment scenario in the development of depression in susceptible humans.…”

Section: Depression As a Results Of Gene-environment Interactionmentioning

confidence: 99%

Neurochemical and Behavioural Changes in Rat Models of Depression

Skelin¹,

Kovačević²,

Dikšić³

2011

Croat. Chem. Acta

View full text Add to dashboard Cite

Abstract. Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. The study of human depression is hindered by the relatively significant heterogeneity of this disorder. As a result of these heterogeneities, studies using a sound and representative animal model of depression are extremely valuable and, in general, provide important information regarding the neurochemical/biological changes occurring during depression and the subsequent treatment of its symptoms. In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics of a good animal model; face, predictive and constructive validities. We also emphasize the brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi: 10.5562/cca1817) Keywords: depression, olfactory bulbectomized rat model of depression, Flinders sensitive line rat, Flinders Resistant line rat, animal model of depression

show abstract

Maternal separation alters drug intake patterns in adulthood in rats

Cited by 177 publications

References 123 publications

Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats

Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats

Prenatal Stress Exposure Increases the Excitation of Dopamine Neurons in the Ventral Tegmental Area and Alters Their Reponses to Psychostimulants

Neurochemical and Behavioural Changes in Rat Models of Depression

Contact Info

Product

Resources

About