Maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes

Kaya, Başak; Turhan, Uğur; Sezer, Salim; Kaya, Serdar; Dağ, İsmail; Tayyar, Ahmet

doi:10.1080/14767058.2019.1637409

Cited by 10 publications

(10 citation statements)

References 29 publications

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“…Galectin 1 (LGALS1) is a β-galactoside-binding protein and regulates maternal–fetal immune tolerance and maintaining a normal pregnancy [ 68 , 69 , 70 ]. The dysregulation of LGALS1 expression is associated with preeclampsia [ 71 ], and interestingly, maternal serum LGALS1 levels are significantly higher in pregnancies with premature ruptures of the membranes [ 72 ]. LGALS1 was predicted as an activated master regulator in male SPTB placenta and interacts with 15 upstream regulators to regulate the gene expression.…”

Section: Resultsmentioning

confidence: 99%

Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth

Lien

Zhang

et al. 2021

IJMS

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A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas, and waste exchanges between the maternal and fetal circulations and is an important endocrine organ producing hormones that regulate both the maternal and fetal physiologies during pregnancy. Placental insufficiency is implicated in spontaneous preterm birth (SPTB). We proposed that deficits in the capacity of the placenta to maintain bioenergetic and metabolic stability during pregnancy may ultimately result in SPTB. To explore our hypothesis, we performed a RNA-seq study in male and female placentas from women with SPTB (<36 weeks gestation) compared to normal pregnancies (≥38 weeks gestation) to assess the alterations in the gene expression profiles. We focused exclusively on Black women (cases and controls), who are at the highest risk of SPTB. Six hundred and seventy differentially expressed genes were identified in male SPTB placentas. Among them, 313 and 357 transcripts were increased and decreased, respectively. In contrast, only 61 differentially expressed genes were identified in female SPTB placenta. The ingenuity pathway analysis showed alterations in the genes and canonical pathways critical for regulating inflammation, oxidative stress, detoxification, mitochondrial function, energy metabolism, and the extracellular matrix. Many upstream regulators and master regulators important for nutrient-sensing and metabolism were also altered in SPTB placentas, including the PI3K complex, TGFB1/SMADs, SMARCA4, TP63, CDKN2A, BRCA1, and NFAT. The transcriptome was integrated with published human placental metabolome to assess the interactions of altered genes and metabolites. Collectively, significant and biologically relevant alterations in the transcriptome were identified in SPTB placentas with fetal sex disparities. Altered energy metabolism, mitochondrial function, inflammation, and detoxification may underly the mechanisms of placental dysfunction in SPTB.

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Section: Resultsmentioning

confidence: 99%

Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth

Lien

Zhang

et al. 2021

IJMS

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“…These studies (Hirashima et al, 2018;Kaya et al, 2020;Taha et al, 2020) have reported that galectins are involved in pathophysiology of preeclampsia. In our study we tested the hypothesis whether galectin-3 could be used as a biomarker predicting early-onset preeclampsia development.…”

Section: Discussionmentioning

confidence: 99%

“…Authors made conclusion, that elevations in serum galectin-3 levels with increments in IR-related parameters and lipid profiles reflect the possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia levels on women with PE. Kaya et al (2020) investigated maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes (PPROM) and compared it with pregnancies delivered at term. Patients complicated with PPROM had significantly higher levels of galectin-1 and galectin-3 than the control group.…”

Section: Discussionmentioning

confidence: 99%

Serum Galectin-3 Levels Are Unlikely to Be a Useful Predictive Marker for Early-onset Preeclampsia Development

2020

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Galectin-3 (gal-3) is lectin which is presumed to interact with extracellular matrix proteins and cell surface glycoproteins in normal and pathophysiological conditions. The expression of gal-3 at the fetal-maternal interface partially overlaps that of gal-1, suggesting that an interplay between them might be important for hypertensive disorders in pregnancy like preeclampsia. The aim of our study was to test the hypothesis whether galectin-3 could be used as a predictive marker for early-onset preeclampsia development. 32 patients with early-onset preeclampsia were examined, mean age 28.8 ± 5.5; and 22 age matched normal pregnancies mean age 28.5 ± 6.0. The enzyme-linked immunosorbent assay (ELISA) was used for measuring serum galectin-3 levels. There were no significant differences between serum levels of galectin-3 in sera of preeclampsia patients compared to normal pregnant women – 14.1 ± 4.77 vs. 15.7 ± 5.95 ng/ml (p>0.05). Serum galectin-3 levels correlated with maternal age (r=0.33; p=0.03) and BMI (body mass index) (r=0.52; p=0.01). Our data suggest that determination of serum galectin-3 levels may not be a useful method for prediction of early-onset preeclampsia. Studies should be aimed to other categories of biomarkers.

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“…New hope was provided by recent reports on confirmed differences in maternal galectin-1 and -3 concentrations in mother's blood in pPROM patients compared to healthy pregnant women. Kaya et al indicate that the above-mentioned galectins occur in statistically significantly higher concentrations in the serum of pregnant women with pPROM compared to healthy patients, regardless of the inflammation of the membranes or other inflammatory factors [37].…”

Section: Galectins In Premature Rupture Of Membranesmentioning

confidence: 99%

The role of galectins in obstetrics with particular emphasis on premature preterm rupture of membranes

et al. 2021

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Maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes

Cited by 10 publications

References 29 publications

Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth

Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth

Serum Galectin-3 Levels Are Unlikely to Be a Useful Predictive Marker for Early-onset Preeclampsia Development

The role of galectins in obstetrics with particular emphasis on premature preterm rupture of membranes

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