Maternal serum human chorionic gonadotropin level at fifteen weeks is a predictor for preeclampsia

Müller, Françoise; Savey, L; Fiblec, Bernard Le; Bussières, Laurence; Ndayizamba, G; Colau, J. C.; Giraudet, P

doi:10.1016/s0002-9378(96)70247-8

Cited by 86 publications

(40 citation statements)

References 17 publications

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“…It is considered that the level of the HCG serum biomarker can also represent a placental marker. Retrospectively, the correlation between beta HCG and placental vascular disruption has been observed, so that the high level of beta HCG markers over 2.5 MOM can indicate a risk of preeclampsia (17,18). The increased level of free-beta HCG biomarkers is the result of placental trophoblast hyperplasia.…”

Section: Discussionmentioning

confidence: 97%

False Positive Values of Biomarkers of Prenatal Screening on Chromosomopathy as Indicators of a Risky Pregnancy

Durkovic¹,

Anđelić²,

Mandić³

et al. 2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Kod 2000 trudnica ura|en je u prvom trimestru trudno}e genetski skrining na hromozomopatije odre |ivanjem biomarkera Pregnancy associated plasma protein-A i free-beta-HCG u maternalnom serumu. Posle dobijanja normalnog kariotipa fetusa, patolo{ke vrednosti bio markera su korelisane sa drugim poreme}ajima trud no }e kako bi se ispitali mogu}i uzroci pozitivnog genetskog skrinin ga. Otkriveno je ukupno 340 la`no pozitivnih nalaza biomar kera (17%). Zna~ajan udeo imao je povi{eni free-beta--HCG (48,24%). Utvr|ena je zna~ajna povezanost (p>0,01) povi {enog free-beta-HCG i krvarenja u trudno}i. U 78,52% trudno}a sa patolo{kim biomarkerima nastale su kompli kacije: 13,82% MISSed, 10,88% spontani poba ~aj, 8,82% indu kovani prekid trudno}e zbog anomalija ploda i 45% poro |aja sa poreme}ajem fetalnog vitaliteta. Rezultati istra`i vanja su pokazali veoma zna~ajnu poveza nost (p>0,01) izme|u pove}ane vrednosti biomarkera free-beta-HCG i fetalne hipoksije. La`no pozitivan genetski skri ning uzrok o van povi{e nim free-beta-HCG mo`e da bude pokazatelj pla centarne disfunkcije i poreme}aja fetalnog vitaliteta.

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Section: Discussionmentioning

confidence: 97%

False Positive Values of Biomarkers of Prenatal Screening on Chromosomopathy as Indicators of a Risky Pregnancy

Durkovic¹,

Anđelić²,

Mandić³

et al. 2011

Journal of Medical Biochemistry

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“…Various serum proteins are considered to contribute to the symptoms of PE, such as placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1), soluble fms-like tyrosine kinase-1(sFlt-1), placental protein 13 (PP-13), pregnancy-associated plasma protein A (PAPP-A), human chorionic gonadotrophin (HCG), soluble endoglin (sEng), alpha fetoprotein (AFP), insulin like growth factor-1 and IGF-binding protein-1 (IGFBP-1) (Muller et al, 1996;Bersinger and Odegard, 2004;Audibert et al, 2005;Venkatesha et al, 2006;Baumann et al, 2007;Spencer et al, 2008;Teixeira et al, 2008). Various studies have shown that the expression levels of these proteins increase or decrease according to the disorder and its degree in PE (Baumann et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Discovery of the serum biomarker proteins in severe preeclampsia by proteomic analysis

et al. 2011

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Preeclapsia (PE) is a severe disorder that occurs during pregnancy, leading to maternal and fetal morbidity and mortality. PE affects about 3-8% of all pregnancies. In this study, we conducted liquid chromatographymass spectrometry/mass spectrometry (LC-MS/MS) to analyze serum samples depleted of the six most abundant proteins from normal and PE-affected pregnancies to profile serum proteins. A total of 237 proteins were confidently identified with ＜ 1% false discovery rate from the two groups of duplicate analysis. The expression levels of those identified proteins were compared semiquantitatively by spectral counting. To further validate the candidate proteins with a quantitative mass spectrometric method, selective reaction monitoring (SRM) and enzyme linked immune assay (ELISA) of serum samples collected from pregnant women with severe PE (n = 8) or normal pregnant women (n = 5) was conducted. α2-HS-glycoprotein (AHSG), retinol binding protein 4 (RBP4) and α-1-microglobulin/bikunin (AMBP) and Insulin like growth factor binding protein, acid labile subunit (IGFBP-ALS) were confirmed to be differentially expressed in PE using SRM (P ＜ 0.05). Among these proteins, AHSG was verified by ELISA and showed a statistically significant increase in PE samples when compared to controls.

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“…Several biomarkers and clinical characteristics have been evaluated as predictors of preeclampsia. Several studies have demonstrated an association between elevated second trimester maternal β-HCG and later development of Preeclampsia (Muller et al, 1996;Luckas et al, 1998;Walton et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Expression of Human Chorionic Gonadotropin (ßhCG) in Pre-eclamptic Placenta

et al. 2015

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Maternal serum human chorionic gonadotropin level at fifteen weeks is a predictor for preeclampsia

Cited by 86 publications

References 17 publications

False Positive Values of Biomarkers of Prenatal Screening on Chromosomopathy as Indicators of a Risky Pregnancy

False Positive Values of Biomarkers of Prenatal Screening on Chromosomopathy as Indicators of a Risky Pregnancy

Discovery of the serum biomarker proteins in severe preeclampsia by proteomic analysis

Expression of Human Chorionic Gonadotropin (ßhCG) in Pre-eclamptic Placenta

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