Maternal serum leptin concentration in gestational diabetes

Soheilykhah, Sedigheh; Mojibian, Mahdieh; Rahimi-Saghand, Soodabeh; Rabiei, Maryam; Hadinedoushan, Hossein

doi:10.1016/j.tjog.2011.01.034

Cited by 34 publications

(38 citation statements)

References 20 publications

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“…A growing number of studies in pregnancies complicated by GDM have strongly supported the relationship of hyperleptinaemia with GDM [30][31][32][33]. Although the reasons behind this are not yet known, leptin secretion by adipocyte in the presence of increased estrogen [34] or/and by placenta [35] is possible.…”

Section: Leptinmentioning

confidence: 99%

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Wójcik¹,

Chmielewska-Kassassir²,

Grzywnowicz³

et al. 2014

Endokrynologia Polska

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Gestational diabetes mellitus (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. The prevalence of GDM is growing rapidly worldwide, resulting in numerous and serious complications for both mother and foetus. Two major metabolic disorders, insulin resistance and β cells dysfunction, are currently linked to the pathogenesis of GDM, although the cellular mechanisms involved in the development of GDM are not yet completely understood. Increasing evidence from clinical and experimental studies indicates that adipose tissue dysfunction, characterised by abnormal production of adipokines, is an essential factor linked to insulin resistance and GDM. To date, several adipose tissue-derived hormones have been identified, including leptin, adiponectin, resistin, visfatin, apelin, retinol-binding protein 4 (RBP-4), vaspin, and omentin. The relationship of leptin and adiponectin to insulin resistance in GDM is relatively well documented, but the molecular mechanisms by which these hormones affect insulin resistance are not yet fully known. The other aforementioned adipokines appear to be also important players in the pathophysiology of GDM, although their precise function in this complex process remains to be established. The aim of this article is to review the literature concerning the relationship between the above-mentioned adipokines and GDM, and to clarify their role in the pathophysiology of GDM. Key words: adipokines; adiponectin; gestational diabetes mellitus (GDM); leptin; omentin; RBP-4; resistin; vaspin; visfatin StreszczenieCukrzyca ciążowa (GDM) jest definiowana jako nietolerancja glukozy, która po raz pierwszy wystąpiła lub została wykryta w czasie ciąży. Zachorowalność na GDM szybko wzrasta na świecie, prowadząc do licznych i poważnych powikłań zarówno u matki, jak i płodu. Dwa główne zaburzenia metaboliczne, czyli oporność na insulinę i dysfunkcja komórek b, biorą udział w patogenezie GDM, jednak komórkowe mechanizmy prowadzące do jej rozwoju nie są jeszcze do końca poznane. Wyniki badań klinicznych i eksperymentalnych wskazują, że dysfunkcja tkanki tłuszczowej, charakteryzująca się nieprawidłową produkcją adipokin, jest istotnym czynnikiem związanym z GDM. Do tej pory zidentyfikowano kilka hormonów wytwarzanych przez tkankę tłuszczową, w tym leptynę, adiponektynę, rezystynę, wisfatynę, apelinę, białko wiążące retinol 4 (RBP-4), waspinę i omentynę. Spośród nich stosunkowo dobrze udokumentowany jest związek leptyny i adiponektyny z insulinoopornością w GDM, ale molekularne mechanizmy działania obydwu hormonów w tym procesie nie są jeszcze całkowicie wyjaśnione. Pozostałe wyżej wymienione adipokiny wydają się być również istotnymi czynnikami w patofizjologii GDM, chociaż ich dokładna funkcja w tym kompleksowym procesie pozostaje niejasna. Celem niniejszego artykułu był przegląd istniejącej literatury dotyczącej związku między wyżej wymienionymi adipokinami i GDM oraz wyjaśnienie ich roli w patofizjologii GDM. (Endokrynol Pol 2014; 65 (2): 1...

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Section: Leptinmentioning

confidence: 99%

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Wójcik¹,

Chmielewska-Kassassir²,

Grzywnowicz³

et al. 2014

Endokrynologia Polska

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“…The concentration of leptin is increased during normal pregnancy. 90,91 Leptin levels correlate with insulin sensitivity in pregnancy in women with normal glucose tolerance and GDM. 22,91,92 Further, leptin administration to a mouse model of T1DM reduced BGLs, HbA1c and hyperketonaemia.…”

Section: Maternal Factors Affecting Insulin Requirements In Pregnancymentioning

confidence: 99%

“…90,91 Leptin levels correlate with insulin sensitivity in pregnancy in women with normal glucose tolerance and GDM. 22,91,92 Further, leptin administration to a mouse model of T1DM reduced BGLs, HbA1c and hyperketonaemia. 93,94 Leptin also increases hepatic glycogen 93 and suppresses glucagon and growth hormone.…”

Section: Maternal Factors Affecting Insulin Requirements In Pregnancymentioning

confidence: 99%

Factors determining insulin requirements in women with type 1 diabetes mellitus during pregnancy: a review

2014

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Most women with type 1 diabetes mellitus (T1DM) have increased insulin requirements during pregnancy. However, a minority of women have a fall in insulin requirements. When this occurs in late gestation, it often provokes concern regarding possible compromise of the feto-placental unit. In some centres, this is considered as an indication for delivery, including premature delivery. There are, however, many other factors that affect insulin requirements in pregnancy in women with type 1 diabetes mellitus and the decline in insulin requirements may represent a variant of normal pregnancy. If there is no underlying pathological process, expedited delivery in these women is not warranted and confers increased risks to the newborn. We will explore the factors affecting insulin requirements in gestation in this review. We will also discuss some novel concepts regarding beta-cell function in pregnancy.

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“…In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index (r = 0.221, p = 0.03) and (r = 0.246, p = 0.03), respectively. (Soheilykhah et al, 2011) In a case-control study, noted that maternal third trimester leptin concentrations were significantly lower in GDM cases as compared with controls after adjusting for possible confounding factors such as BMI and insulin concentrations (Festa et al, 1999). Concentration of leptin increased before the appearance of the abnormal glucose level during pregnancy (Xue-lian et al, 2008).…”

Section: Leptin and Gestational Diabetesmentioning

confidence: 99%

Maternal serum leptin concentration in gestational diabetes

Abstract: Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.

Cited by 34 publications

References 20 publications

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Factors determining insulin requirements in women with type 1 diabetes mellitus during pregnancy: a review

The Role of Adipocyte Mediators, Inflammatory Markers and Vitamin D in Gestational Diabetes

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