Maternal serum omentin-1 profile is similar in humans and in the rat animal model

Garcés, María Fernanda; Ruíz-Linares, Carlos E.; Vallejo, Sergio; Peralta, Jhon J.; Sánchez, Elizabeth; Ortiz-Rovira, Alexsandra; Curtidor, Yurani; Parra, Mario Orlando; Leal, Luis; Alzate, Juan Pablo; Acosta, B.; Diéguez, Carlos; Nogueiras, Rubén; Caminos, Jorge Eduardo

doi:10.1016/j.cyto.2015.06.014

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Similarly, Schuermann et al (2019) found it to remain low until the pre-breeding period (4 th week after parturition). In human studies, generally, a negative correlation is found between serum omentin-1 levels and serum TG levels similar to our findings (Yan et al, 2011;Garces et al, 2015;Korany et al, 2018).…”

Section: Discussionsupporting

confidence: 92%

“…In the same study, omentin-1 levels, measured in women during the three trimesters (early, mid, and late pregnancy), were observed to be significantly lower in mid and late pregnancy compared to the levels in non-pregnant women. Similarly, in pregnant rats and women, omentin-1 levels were low by the end of pregnancy (Garces et al, 2015). On the contrary, in the present study conducted on cows, omentin-1 levels started to increase in the serum on the 14 th day before parturition and the level was found to be significantly high during parturition (Figure 1), decreasing again by the 14 th day after parturition.…”

Section: Discussioncontrasting

confidence: 48%

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Investigation of omentin-1 and metabolic parameters in periparturient cows

Aygörmez

Atakişi

2021

J Hellenic Vet Med Soc

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We aimed to determine the level of omentin-1 hormone and other in periparturient period of dairy cows. It was also aimed to determine whether there is a correlation between omentin-1, glucose, Non-esterified fatty acids (NEFA), triglycerides (TG) and β-hydroxybutyrate (BHB). Blood samples were taken a month before parturition (PreP30), two weeks before parturition (PreP14), at parturition (P), two weeks after parturition (PostP14) and a month after parturition (PostP30). Concentrations of serum omentin-1 at P, serum glucose at P, PostP14, and PostP30, serum NEFA at P, serum TG PreP30 and PreP14, and serum BHB at P were statistically significantly higher than at other times. A positive correlation was observed between omentin-1 and glucose, NEFA and BHB, glucose and NEFA and BHB, and NEFA and BHB. A negative correlation was found between TG and omentin-1, glucose, NEFA and BHB. In conclusion, findings of the present study shows that omentin-1 may play an important role in the periparturient period. A positive correlation of omentin-1 with energy fuels NEFA, glucose, and BHB suggests that omentin-1 plays a role in energy metabolism like other adipokines. The fact that omentin-1 levels increase during delivery, when the fetus needs energy most, supports this hypothesis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 48%

Investigation of omentin-1 and metabolic parameters in periparturient cows

Aygörmez

Atakişi

2021

J Hellenic Vet Med Soc

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“…Little has been reported around omentin, an adipokine with anti-inflammatory activity, in experimental models of developmental programming. Maternal circulating omentin profiles are similar between humans and rodents (Garces et al 2015). In clinical studies, preexisting maternal obesity associates with a reduction in expression of omentin-1 in placenta, adipose tissue and maternal plasma and alterations in omentin-1 in pregnancy were therefore proposed to play a role in the development of metabolic disorders in offspring in later life.…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

The role of adipokines in developmental programming: evidence from animal models

Reynolds

Vickers

2019

Journal of Endocrinology

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Alterations in the environment during critical periods of development, including altered maternal nutrition, can increase the risk for the development of a range of metabolic, cardiovascular and reproductive disorders in offspring in adult life. Following the original epidemiological observations of David Barker that linked perturbed fetal growth to adult disease, a wide range of experimental animal models have provided empirical support for the developmental programming hypothesis. Although the mechanisms remain poorly defined, adipose tissue has been highlighted as playing a key role in the development of many disorders that manifest in later life. In particular, adipokines, including leptin and adiponectin, primarily secreted by adipose tissue, have now been shown to be important mediators of processes underpinning several phenotypic features associated with developmental programming including obesity, insulin sensitivity and reproductive disorders. Moreover, manipulation of adipokines in early life has provided for potential strategies to ameliorate or reverse the adverse sequalae that are associated with aberrant programming and provided insight into some of the mechanisms involved in the development of chronic disease across the lifecourse.

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“…Serum omentin-1 is also significantly lower in gestational diabetes than that in pregnant women with normal glucose tolerance and is closely associated with gestational diabetes and probably participates in the occurrence and development of gestational diabetes [26]. Human and rat serum omentin-1 levels are lower in the late gestational period than those in nonpregnant women and virgin rats, and human serum omentin-1 level has an inverse relationship with the triglyceride level during pregnancy [27]. Leptin was increased in diabetic pregnant women [28].…”

Section: Discussionmentioning

confidence: 99%

Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes

Zhou

Du²,

Zuo³

et al. 2017

Pharmacology

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Background: As an active component from traditional Chinese medicine, trigonelline has a protective effect on diabetes. This study evaluated the protective effects of trigonelline on diabetic mice during pregnancy. Methods: Diabetes was induced in female mice by intraperitoneal injection for continuous 5-day of 40 mg/kg/day streptozotocin. Female mice were divided into 4 groups after they were allowed to mate with normal male mice: nondiabetic, nondiabetic treated with trigonelline (70 mg/kg) for 18 days, diabetic, and diabetic treated with trigonelline (70 mg/kg). Results: Diabetic pregnant mice had significantly higher levels of blood glucose, serum total cholesterol, triglyceride, insulin, and leptin but lower serum omentin-1 level and insulin sensitivity index than the nondiabetic ones. Trigonelline improved the hyperglycemia, dyslipidemia, insulin resistance, and adipocytokine of diabetic pregnant mice. Diabetic pregnant mice had significantly reduced fetus numbers, fetal weight, and fetal/placental ratio, which were reversed by trigonelline. Trigonelline prevented the increase in proinflammatory cytokines and reduced interleukin-10 level in placenta of diabetic pregnant mice. Trigonelline increased β-cell replication and the decreased β-cell mass, and decreased the β-cell apoptosis of diabetic pregnant mice. Conclusion: These findings suggest that trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis.

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Maternal serum omentin-1 profile is similar in humans and in the rat animal model

Cited by 9 publications

References 28 publications

Investigation of omentin-1 and metabolic parameters in periparturient cows

Investigation of omentin-1 and metabolic parameters in periparturient cows

The role of adipokines in developmental programming: evidence from animal models

Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes

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