Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth

Hudić, Igor; Stray‐Pedersen, Babill; Szekeres-Barthó, Júlia; Fatušić, Zlatan; Dizdarević-Hudić, Larisa; Tomić, Vajdana; Polgar, Beata; Hadžiefendić, Bahrudin; Fatusic, Jasenko

doi:10.1016/j.jri.2015.02.006

Cited by 31 publications

(23 citation statements)

References 19 publications

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“…Progesterone has been established to inhibit myometrial contractility, and progesterone withdrawal has been linked to the start of labour 2,3 . In addition, progesterone has been posited to play a crucial role in regulating the maternal immune response and preventing rejection of the fetal semi-allograft, which is mediated through PIBF 4,5 .…”

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confidence: 99%

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

Lim

Tan

et al. 2020

Sci Rep

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Progesterone-induced blocking factor (PIBF), which plays an important role in maintaining healthy pregnancies, has shown great promise as a prognostic biomarker for threatened miscarriage. To better characterise the physiological trends of progesterone and PIBF, we analysed serum progesterone and PIBF concentrations in healthy non-pregnant and pregnant women across trimesters. We saw increasing concentrations of progesterone and PIBF in pregnant women with advancing trimesters. The serum progesterone and piBf percentiles across gestational age in healthy pregnancies can be used as a guide for the formulation of reference ranges. We also demonstrated a significant positive correlation between progesterone and PIBF levels. This study demonstrates increasing progesterone and PIBF concentrations in later trimesters and underscores the importance of progesterone and piBf in healthy pregnancies. Characterisation of progesterone and PIBF across gestational age in healthy pregnant women may help to prognosticate pregnancy viability and support further research into the importance of progesterone and PIBF in the maintenance of healthy pregnancies.

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confidence: 99%

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

Lim

Tan

et al. 2020

Sci Rep

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“…The progesterone-inducible molecule PIBF1 carries out many effector functions of progesterone in pregnancy 30 , and a lower serum concentration of PIBF1 in late pregnancy is associated with an increased risk of human PTL 31 . Full-length 90-kDa PIBF1 is a nucleus- or centrosome-associated protein 32 , whereas several alternatively spliced shorter isoforms, including the 35-, 48-, 57- and 67-kDa isoforms, can be secreted by certain tumor cells and by immune cells and trophoblasts during pregnancy, and are biologically active 32–34 .…”

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confidence: 99%

Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor

Huang

Faucette

Pawlitz

et al. 2016

Nat Med

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Preterm birth (PTB) is a leading cause of neonatal death worldwide1. Intrauterine and systemic infection and inflammation cause 30–40% of spontaneous preterm labor (PTL)2, which precedes PTB. Although antibody production is a major immune defense mechanism against infection, and B cell dysfunction has been implicated in pregnancy complications associated with PTL3,4, the functions of B cells in pregnancy are not well known5–8. We found that choriodecidua of women undergoing spontaneous PTL harbored functionally altered B cell populations. B cell–deficient mice were markedly more susceptible than wild-type (WT) mice to PTL after inflammation, but B cells conferred interleukin (IL)-10-independent protection against PTL. B cell deficiency in mice resulted in a lower uterine level of active progesterone-induced blocking factor 1 (PIBF1), and therapeutic administration of PIBF1 mitigated PTL and uterine inflammation in B cell–deficient mice. B cells are a significant producer of PIBF1 in human choriodecidua and mouse uterus in late gestation. PIBF1 expression by B cells is induced by the mucosal alarmin IL-33 (ref. 9). Human PTL was associated with diminished expression of the a-chain of IL-33 receptor on choriodecidual B cells and a lower level of active PIBF1 in late gestation choriodecidua. These results define a vital regulatory cascade involving IL-33, decidual B cells and PIBF1 in safeguarding term pregnancy and suggest new therapeutic approaches based on IL-33 and PIBF1 to prevent human PTL.

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“…This was confirmed later by several studies. Hudić et al [85] was able to predict preterm births based on lower-than-normal pregnancy PIBF values within 5 days before labor, while Beta et al [86] showed that in women who have a spontaneous early preterm delivery the maternal serum levels of PIBF are not altered at 11-13 weeks of gestation. In line with this, Check et al [87] reported that the failure to detect PIBF at 3-5 weeks of seemingly normal pregnancy is associated with a higher rate of miscarriage.…”

Section: Cytokine-like Effects Of Pibf Contribute To the Maintenance mentioning

confidence: 99%

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

Szekeres-Barthó

2018

Med Princ Pract

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This review aims to provide a brief historical overview of the feto-maternal immunological relationship, which profoundly influences the outcome of pregnancy. The initial question posed in the 1950s by Medawar [Symp Soc Exp Biol. 1953; 7: 320–338] was based on the assumption that the maternal immune system recognizes the fetus as an allograft. Indeed, based on the association between HLA-matching and spontaneous miscarriage, it became obvious that immunological recognition of pregnancy is required for a successful gestation. The restricted expression of polymorphic HLA antigens on the trophoblast, together with the presence of nonpolymorphic MHC products, excludes recognition by both T and NK cells of trophoblast-presented antigens; however, γδ T cells, which constitute the majority of decidual T cells, are likely candidates. Indeed, a high number of activated, progesterone receptor-expressing γδ T cells are present in the peripheral blood of healthy pregnant women and, in the presence of progesterone, these cells secrete an immunomodulatory protein called progesterone-induced blocking factor (PIBF). As early as in the peri-implantation period, the embryo communicates with the maternal immune system via PIBF containing extracellular vesicles. PIBF contributes to the dominance of Th2-type reactivity which characterizes normal pregnancy by inducing increased production of Th2 cytokines. The high expression of this molecule in the decidua might be one of the reasons for the low cytotoxic activity of decidual NK cells.

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Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth

Cited by 31 publications

References 19 publications

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

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