Maternal serum vitamin D levels and preterm delivery among low‐risk parturients in Lagos, Nigeria

Oluwole, Ayodeji A.; Okunade, Kehinde Sharafadeen; Okojie, Osemen Ehidiamen

doi:10.1002/ijgo.12719

Cited by 15 publications

(16 citation statements)

References 20 publications

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“…Reports indicate that about 15 million infants worldwide are born preterm [ 31 ]. Oluwole and co-workers demonstrated that pregnant women with vitamin D deficiency have an approximately 9-fold higher likelihood of preterm delivery [ 32 ]. Similarly, Kalok [ 33 ] observed a significant correlation between vitamin D level and gestational age at delivery.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Fondjo

Tashie

Owiredu

et al. 2021

BMC Pregnancy Childbirth

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Background Hypovitaminosis D in pregnancy is associated with adverse health outcomes in mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin D [25(OH)D] in normotensive pregnancies and in preeclampsia, evaluated the association between vitamin D deficiency and preeclampsia risk; and determined the foeto-maternal outcome in preeclamptic women with vitamin D deficiency. Methods This case-control study was conducted among pregnant women who visited the Comboni Hospital, in Ghana from January 2017 to May 2018 for antenatal care. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Socio-demographic, clinical and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of 25- hydroxyvitamin D [25(OH)D] using enzyme-linked immunosorbent assay technique. Lipids (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol) were also estimated. Results A total of 81.7% of the study participants had vitamin D deficiency. Of these, 88.6% of the women with PE had vitamin D deficiency compared to 75.0% in the NP. Vitamin D levels were significantly reduced in the PE women compared to the normotensive pregnant women (p = 0.001). A higher proportion of the preeclamptic women who were vitamin D deficient had preterm delivery (p < 0:0001) and delivered low birth weight infants (p < 0:0001), and infants with IUGR (p < 0:0001) compared to the control group (p < 0:0001). Pregnant women with PE presented with significant dyslipidemia, evidenced by significantly elevated TC (p = 0.008), LDL (p < 0.0001), triglycerides (p = 0.017) and a significantly reduced HDL (p = 0.001) as compared to NP. In the preeclamptic women, serum 25(OH) D showed an inverse, but not significant association with TC (β = − 0.043, p = 0.722, TG (β = − 0.144, p = 0.210) and LDL (β = − 0.076, p = 0.524) and a positive, but not significant association with HDL (β = 0.171, p = 0.156). Conclusion The prevalence of vitamin D deficiency is high in both normotensive pregnancies and pregnancies complicated by preeclampsia but amplified in preeclampsia. Higher proportion of pregnant women with hypovitaminosis D had preterm babies and delivered low birth weight neonates. Additional studies are needed to explore the potential benefits and optimal dosing of vitamin D use in pregnancy, especially in sub-Saharan Africa.

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Section: Discussionmentioning

confidence: 99%

High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Fondjo

Tashie

Owiredu

et al. 2021

BMC Pregnancy Childbirth

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show abstract

“…Reports indicate that about 15 million infants worldwide are born preterm [29]. Oluwole and co-workers demonstrated that pregnant women with vitamin D de ciency have an approximately 9-fold higher likelihood of preterm delivery [30].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Fondjo

Tashie

Owiredu

et al. 2021

Preprint

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Background: Hypovitaminosis D in pregnancy is associated with adverse health outcomes in mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin D [25(OH)D] in normotensive pregnancies and pregnancies complicated by preeclampsia, and evaluated the association between vitamin D deficiency and foeto-maternal outcome. Methods: This case-control study was conducted among pregnant women who visited the Comboni Hospital, in Ghana from January 2017 to May 2018 for antenatal care. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Socio-demographic, clinical and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of 25(OH)D using enzyme-linked immunosorbent assay technique. Lipids (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol) and were also estimated. Results: A total of 81.7% of the study participants had vitamin D deficiency. Of these, 88.6% of the women with PE had vitamin D deficiency compared to 75.0% in the NP. Vitamin D levels was significantly reduced in the PE women compared to the normotensive pregnant women (p=0.001). A higher proportion of the preeclamptic women who were vitamin D deficient had preterm delivery (p < 0:0001) and delivered low birth weight infants (p < 0:0001), and infants with IUGR (p < 0:0001) compared to the control group (p < 0:0001). Pregnant women with PE presented with significant dyslipidaemia, evidenced by significantly elevated TC (p=0.008), LDL (p<0.0001), triglycerides (p=0.017) and a significantly reduced HDL (p=0.001) as compared to NP. In the preeclamptic women, serum 25(OH)D showed an inverse, but not significant association with TC (β= -0.087, p=0.464), TG (β= -0.143, p=0.233) and LDL (β= -0.101, p=0.388) and a positive, but not significant association with HDL (β= 0.166, p=0.154). Conclusion: The prevalence of vitamin D deficiency is high in both normotensive pregnancies and pregnancies complicated by preeclampsia but amplified in preeclampsia. Higher proportion of pregnant women with hypovitaminosis D had preterm babies and delivered low birth weight neonates. Additional studies are needed to explore the potential benefits and optimal dosing of vitamin D use in pregnancy especially in sub-Saharan Africa.

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“…Keterbatasan penelitian ini seharusnya terfokus kepada wanita reproduksi sehat sehingga peneliti menyarankan untuk selanjutnya perlu penelitian lanjutan tentang hipovitaminosis D dalam kehamilan dan kesehatan reproduksi. Penelitian Oluwole, Okunade, & Okojie (2019) Hasil statistik menunjukan prevalensi defisiensi vitamin D relatif rendah pada ibu melahirkan di Lagos-Nigeria dan ada kemaknaan secara statistik ibu hipovitaminosis D dengan persalinan prematur. Peneliti mengakui bahwa dalam penelitian ini dipilih populasi wanita yang berpendidikan dan cenderung melakukan diet yang kaya akan vitamin D dan nutrisi lain dibandingkan dengan wanita yang melahirkan di luar fasilitas kesehatan.…”

Section: Pembahasanunclassified

Persalinan Prematur Karena Kurangnya Vitamin D

Fauzi¹

2020

JurKebMal

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Latar Belakang: Kejadian defisiensi vitamin D banyak terjadi pada kelompok usia berisiko, diantaranya adalah bayi dengan berat lahir rendah, ibu hamil dan orang lanjut usia. Kebutuhan gizi ibu hamil terdiri dari makromineral dan mikromineral yang harus dicukupi selama hamil, salah satu kebutuhan mikromineral yang dibutuhkan ibu saat hamil adalah vitamin D. Vitamin D yang tidak tercukupi dengan baik, meningkatkan risiko terjadinya preeklampsia, diabetes gestasional, persalinan prematur, terhambatnya pertumbuhan janin, abortus spontan, serta berat bayi lahir rendah.Tujuan: Untuk mengetahui hubungan antara kekurangan vitamin D dengan kejadian persalinan prematurMetode: Metode literature review terhadap artikel-artikel mengenai vitamin D pada wanita hamil yang dapat menurunkan risiko kejadian persalinan prematur (<37 minggu). Kriteria inklusi yang digunakan adalah manfaat vitamin D yang dihasilkan dari sediaan suplemen dan juga vitamin D yang dihasilkan dari paparan langsung sinar matahari yang dapat menurunkan risiko kejadian persalinan premature dan berat bayi lahir rendah. Kriteria eksklusi dalam penyusunan artikel ini adalah artikel yang abstrak, artikel yang tidak menggunakan Bahasa Inggris dan artikel yang tidak full teksHasil: Tidak ada hubungan signifikan antara kekurangan vitamin D dengan kejadian persalinan prematur namun prevalensi kejadian rendahnya kadar serum vitamin D ditemukan pada wanita yang bersalin prematur.Kesimpulan: Prevalensi defisiensi vitamin D serum lebih tinggi pada wanita dengan persalinan prematur dibandingkan mereka yang melahirkan matur. Peran potensial dari suplementasi vitamin D prenatal dalam pencegahan kelahiran prematur harus diselidiki lebih lanjut.Saran: Perlu dilakukan penelitian lebih lanjut khususnya di Indonesia baik di perkotaan maupun pedesaan mengenai kandungan serum 25(OH)D dengan melihat karakteristik dari ibu hamil serta lingkungannya. Kata Kunci: Kekurangan Vitamin D, Persalinan Prematur

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Maternal serum vitamin D levels and preterm delivery among low‐risk parturients in Lagos, Nigeria

Cited by 15 publications

References 20 publications

High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Persalinan Prematur Karena Kurangnya Vitamin D

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