Maternal soybean diet during lactation alters breast milk composition and programs the lipid profile in adult male rat offspring

Vieira, Adriana Moura; Brasiel, Poliana Guiomar de Almeida; Ferreira, Maíra Schuchter; Mateus, Kácia; Figueiredo, Mariana Sarto; Lisboa, Patrícia Cristina; Moura, Egberto Gaspar de; Corrêa, José Otávio do Amaral; Lopes, Fernando César Ferraz; Silva, Paulo Henrique Fonseca da; Sabarense, Céphora Maria; Dutra, Sheila Cristina Potente; Aguiar, Aline Silva de

doi:10.1007/s12020-018-1572-x

Cited by 16 publications

(13 citation statements)

References 44 publications

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“…Perinatal environment, including lactation, is also a very important programming window considered to play a critical role in the development of the offspring [1]. Though the breast milk is mainly affected by the lactation diet, it is inevitable that gestational diet would also have certain influence on the composition [40]. Therefore, it is important to study the composition of nutrients and hormones in breast milk, which was what we neglected when designing the experiment.…”

Section: Discussionmentioning

confidence: 99%

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Zhou

Lin

et al. 2019

Reprod Biol Endocrinol

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BackgroundExcessive gestational weight gain (GWG), which is associated with adverse long-term effects on the health of the offspring, has become a major clinical problem. Accumulating evidence indicates that the ovary kisspeptin/GPR54 system directly participates in a series of physiological activities. We used a model of high-fat diet (HFD) during gestational to investigate offspring’s ovarian function and whether kisspeptin/GPR54 system is involved.MethodsAfter introducing the male and confirmation of mating by checking a vaginal sperm plug, female rats were randomized into two groups: control diet called NCD group and high-fat diet called HFD group. After birth, all rats were changed into a control diet and litter size was adjusted to 12 pups per litter. Ovaries were collected for assessment at postnatal day (PND) 4 and PND 30. The timing of vaginal opening was recorded, and the estrous cyclicity was monitored for 2 consecutive weeks immediately. Primary granulosa cells and ovaries which were taken from PND 4 were collected for determination of the direct effect of kisspeptin-10 (kp-10) in vitro.ResultsNeonatal rats exposed to HFD during gestation had a lower number of secondary follicles in the ovary. The expression of follicle-stimulating hormone receptor (FSHR) and kisspeptin was not altered. At prepuberty, the number of antral follicles and preovulatory follicles was elevated with decreased type III follicles in the HFD group. While the expression of ovulation-related genes was decreased, the expression levels of follicular growth-related genes and steroidogenesis synthesis related genes were elevated. A significant increase in kiss1 mRNA and kisspeptin protein was detected without changes in kiss1r mRNA and GPR54. Maternal high-fat diet during gestation resulted in a significant advanced puberty onset and an irregular estrous cycle in offspring rats. In addition, the administration of kp-10 produced an increase in viability of primary granulosa cells and enlarged the size of oocytes.ConclusionsHFD exposure during maternal gestation had a long-term effect on reproductive function in the offspring and the increased ovarian kisspeptin/GPR54 system might be involved.Electronic supplementary materialThe online version of this article (10.1186/s12958-019-0457-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Zhou

Lin

et al. 2019

Reprod Biol Endocrinol

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“…Recognizing its etiology is essential to face the global epidemic. This creates a challenge since the pathway to obesity in many individuals begins before birth; a predisposition to obesity can occur through epigenetic and other forms of early programming, and obesity and its metabolic consequences result from physiological changes set during fetal and early postnatal development [17][18][19].…”

Section: The Early-life Origins Of Obesitymentioning

confidence: 99%

“…In a study developed by our research group, we identified that the maternal intake of soybeans in lactation changed the lipid content of breast milk and programmed offspring for a phenotype of the lower metabolic risk. The difference in fat content of breast milk and the higher isoflavones content of soy diet are possible imprinting factors that could program the offspring [18]. This is particularly important because it highlights the dual role of nutritional alterations, whether as reprogramming strategies to prevent disease or leading to adult disease [40].…”

Section: Metabolic Pathways and Epigeneticsmentioning

confidence: 99%

Metabolic Programming and Nutrition

Brasiel¹,

Luquetti²

2021

New Insights Into Metabolic Syndrome

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Epidemiological and experimental studies have and continue to offer valuable insight into the Developmental Origins of Health and Disease (DOHaD) hypothesis, which emphasizes the importance of early-life nutritional and environmental changes on the increased risk of metabolic diseases in later life. It is now known that non-communicable chronic diseases that were previously associated with lifestyle and genetics have their origins early in life. It is well established that early life environmental signals, including nutrition, set the stage for long-term health and disease risk—effects that span multiple generations. This relationship began still in the intrauterine period and extends throughout the critical period of development. Many types of nutritional challenges including caloric restriction, macronutrient excess, and micronutrient insufficiencies have been shown to induce early life adaptations that produce long-term dysfunction. Several pathways have been suggested to underpin these associations, including epigenetic reprogramming of germ cells. While the mechanisms still remain to be fully investigated, the relationship of nutrition factors in early life and metabolic diseases are clear. This chapter focuses on the role that the nutrition presents during critical periods of development and its repercussions into adulthood.

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“…Commercial organic soy and soy protein isolates were processed to inactivate antinutritional factors. After, they were transformed into flour for the preparation of the soybean experimental diet, according to the methods of Soares et al 26 and Vieira et al 22 . The centesimal composition of the soy flour was analyzed according to reference methods 27 .…”

Section: Animals and Dietsmentioning

confidence: 99%

“…Recently, our group observed changes in the lipid profile of breast milk from lactating rats placed on a soybean diet, which programmed adult offspring for a phenotype of lower metabolic risk, low total cholesterol (TC) and LDL-cholesterol, and protection against changes in glycemic metabolism 22 . However, soy protein isolate consumption in the same model programmed the offspring to negative effects on body composition, lipid profile, and glycemic homeostasis, generating a profile of higher metabolic risk in adulthood 23 .…”

Section: Introductionmentioning

confidence: 99%

Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring

Ferreira

Luquetti

Brasiel

et al. 2021

J Dev Orig Health Dis

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The benefits of consuming soy and its protein have been reported in many studies. However, its phytoestrogen content raises concerns about consumption during lactation and gestation We therefore examined the effects of soybean or soy protein isolate on the parameters-related cardiovascular pathophysiology in lactating mothers and their offsprings at weaning and adulthood. Lactating rats were divided: casein control (C); soy protein isolate (SPI); and soybean (S). At weaning, half of the litter received commercial ration up to 150 days. The levels of 17-β-estradiol and superoxide dismutase were low in the S mothers. For the SPI mothers, we observed a reduction of thiobarbituric acid reactive substances (TBARS). At weaning, atherogenic indices [1 = total cholesterol (TC)/HDL; 2 = LDL/HDL; 3 = TC-HDL/HDL)] decreased in the S and SPI offsprings compared to the casein control group; TBARS and antioxidant enzymes increased in the S offspring, while reduced/oxidized glutathione ratio increased in the SPI offspring, indicating lower oxidative stress. In adulthood, the SPI offspring showed an increase in liver cholesterol and atherogenic index 1 and 3 (vs. C and S) and 2 (vs. S). In addition, we found a decrease in catecholamines in the adrenal medulla and an increase in caffeine-stimulated secretion, but tyrosine hydroxylase expression remained constant. Maternal consumption of SPI during lactation worsened atherogenic indices of the offsprings in adulthood, which was associated with increased liver cholesterol and decreased catecholamines in the adrenal medulla. Soy consumption had no consistent long-term effects on the evaluated parameters compared to casein consumption. The data suggest that the consumption of SPI during lactation should be done with caution.

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Maternal soybean diet during lactation alters breast milk composition and programs the lipid profile in adult male rat offspring

Cited by 16 publications

References 44 publications

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Metabolic Programming and Nutrition

Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring

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