Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance

Sivasangari, Karunanithi; Sivamaruthi, Bhagavathi Sundaram; Chaiyasut, Chaiyavat; Rajan, Koilmani Emmanuvel

doi:10.1016/j.heliyon.2023.e20385

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…It was observed that the supplementation of BME dampens maternal stress. Thus, its effect on neurobehaviour, antioxidant defense gene expression, and telomere biology is minimized in their offspring is also minimized [200].…”

Section: Bm and Neurodegenerative Diseases: Evidence From In Vitro An...mentioning

confidence: 99%

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM’s beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases.

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Section: Bm and Neurodegenerative Diseases: Evidence From In Vitro An...mentioning

confidence: 99%

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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Breaking barriers: Maternal gut-brain axis modulation as a catalyst for fetal gut microbiome reshaping: A comprehensive review

Bhanumathy,

Krishnarajabhatt,

Unnikrishnan

2024

Proceedings of the International Conference on Advances in Material Science and Chemistry (Icamsc – 2023)

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Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance

Cited by 2 publications

References 67 publications

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Breaking barriers: Maternal gut-brain axis modulation as a catalyst for fetal gut microbiome reshaping: A comprehensive review

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