Maternal thyroid hormone deficiency and cardiorespiratory disorder in rat pups

Rousseau, Jean‐Philippe; Buteau-Poulin, Anabel; Kinkead, Richard

doi:10.1016/j.expneurol.2019.112960

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Delays in pulmonary ventilation caused by hypothyroidism have been observed in developing rats. Rat pups whose mothers were treated with MMI from initiation of pregnancy through Frontiers in Physiology frontiersin.org 2 weeks post postpartum exhibited altered ventilation function (Rousseau et al, 2019). In both neonatal birds and mammals, hypothyroidism has a negative influence on ventilation development that may be due to alterations of the autonomic nervous system during development.…”

Section: Pulmonary Ventilationmentioning

confidence: 99%

Manipulating plasma thyroid hormone levels alters development of endothermy and ventilation in nestling red-winged blackbirds

Sirsat

Price

et al. 2022

Front. Physiol.

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Thyroid hormones are key regulators of development and metabolism in vertebrates. During the nestling period, young of altricial species transition from an ectothermic phenotype to an endothermic phenotype. Red-winged blackbirds are an altricial species that exhibit an increase in plasma 3,3’, 5-triiodo-L-thyronine (T3) levels during the first 5 days post-hatch (dph), begin to develop endothermic metabolic responses by 7 dph, and fledge within 10 days of hatching. We propose that thyroid hormones play an important role in regulating development of endothermy during the nestling period in altricial birds. To better understand the effects of thyroid hormones on endothermic metabolic development in an altricial species, we treated nestling red-winged blackbirds on 2, 3, and 5 dph with either methimazole (MMI) to induce hypothyroidism or supplemental T3 to induce hyperthyroidism. We then measured on 5, 7, and 9 dph morphology and whole animal O2 consumption (V˙o2) and ventilation in the thermal neutral zone and during gradual cooling. Treatment of nestlings with MMI resulted in lower plasma T3 levels on 5 dph that recovered by 7 dph, while supplementing with T3 did not affect plasma T3 levels on 5, 7 and 9 dph. Treatment with MMI resulted in smaller nestlings with smaller hearts and structural characters such as wing chord and femur length, but larger lungs and kidneys. Treatment with T3 produced smaller nestlings with smaller body masses and shorter femur and tarsus lengths. The development of V˙o2 and ventilation endothermic responses to gradual cooling in MMI treated nestlings were delayed when compared with control nestlings. In 9 dph nestlings, hypothyroidism resulted in alterations in the responses of ventilation frequency and tidal volume to cooling when compared with the control nestlings. Supplemental T3 had no effect on the development of V˙o2 and ventilation in the thermal neutral zone or in response to cooling. Our data suggest plasma thyroid hormone levels play an active role in the systemic development of endothermic capacity and the development of ventilatory control. In the nestling avian, multiple systems develop in concert to produce an endothermic phenotype, but reduced thyroid hormone delays maturation of endothermic capacity.

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Section: Pulmonary Ventilationmentioning

confidence: 99%

Manipulating plasma thyroid hormone levels alters development of endothermy and ventilation in nestling red-winged blackbirds

Sirsat

Price

et al. 2022

Front. Physiol.

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“…TH have a major regulatory role on fetal growth (Forhead and Fowden, 2014), and maturation of the central nervous system (Patel et al, 2011;Stenzel and Huttner, 2013). Furthermore, maternal hypothyroidism is associated with increased rates of respiratory distress syndrome in new-born (Casey et al, 2005;Männistö et al, 2013) and cardiorespiratory disorder (Rousseau et al, 2019). In various mammalian species, TH change the synthesis of the components of surfactant (Ballard et al, 1984;Das et al, 1984;Warburton et al, 1988;Gilbert et al, 2001;Van Tuyl et al, 2004).…”

Section: Involvement Of Thyroid Hormonesmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to the next life stage in a different ecological niche. Metamorphosis, an emblematic type of these post-embryonic developmental processes, has occurred repeatedly and independently in various phylogenetic groups throughout metazoan evolution, such as in cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses and developmental transitions in vertebrates, including typical larval metamorphosis in anuran amphibians, larval and secondary metamorphoses in teleost fishes, egg hatching in sauropsids and birth in mammals. Two neuroendocrine axes, the hypothalamic-pituitary-thyroid and the hypothalamic-pituitary-adrenal/interrenal axes, are central players in the regulation of these life transitions. The review will address the molecular and functional evolution of these axes and their interactions. Mechanisms of integration of internal and environmental cues, and activation of these neuroendocrine axes represent key questions in an “eco-evo-devo” perspective of metamorphosis. The roles played by developmental transitions in the innovation, adaptation, and plasticity of life cycles throughout vertebrates will be discussed. In the current context of global climate change and habitat destruction, the review will also address the impact of environmental factors, such as global warming and endocrine disruptors on hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes, and regulation of developmental transitions.

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Facilitation of microglial motility by thyroid hormones requires the presence of neurons in cell culture: A distinctive feature of the brainstem versus the cortex

Rousseau

Нода

Kinkead

2020

Brain Research Bulletin

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Maternal thyroid hormone deficiency and cardiorespiratory disorder in rat pups

Cited by 5 publications

References 53 publications

Manipulating plasma thyroid hormone levels alters development of endothermy and ventilation in nestling red-winged blackbirds

Manipulating plasma thyroid hormone levels alters development of endothermy and ventilation in nestling red-winged blackbirds

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Facilitation of microglial motility by thyroid hormones requires the presence of neurons in cell culture: A distinctive feature of the brainstem versus the cortex

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