Maternal vitamin A deficiency during pregnancy affects vascularized islet development

Chien, Chiao Yun; Lee, Hsuan-Shu; Cho, Candy Hsin Hua; Lin, Kuo I.; Tosh, David; Wu, Ruei Ren; Mao, Wan Yu; Shen, Chia‐Ning

doi:10.1016/j.jnutbio.2016.07.010

Cited by 15 publications

(9 citation statements)

References 50 publications

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“…Studies suggest that VAD is associated with diabetes mellitus and gestational diabetes [45]. VAD during pregnancy can affect the development of the endocrine pancreas in rats [95], suggesting a possible role of VAD in the pathogenesis of diabetes [96]. A recent study in mice explained why VAD during pregnancy can hamper the development of the endocrine pancreas [96].…”

Section: Vitamin a And Pregnancy: Importance And Effects Of Deficimentioning

confidence: 99%

Vitamin A and Pregnancy: A Narrative Review

et al. 2019

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Vitamin A is a crucial micronutrient for pregnant women and their fetuses. In addition to being essential for morphological and functional development and for ocular integrity, vitamin A exerts systemic effects on several fetal organs and on the fetal skeleton. Vitamin A requirements during pregnancy are therefore greater. Vitamin A deficiency (VAD) remains the leading cause of preventable blindness in the world. VAD in pregnant women is a public health issue in most developing countries. In contrast, in some developed countries, excessive vitamin A intake during pregnancy can be a concern since, when in excess, this micronutrient may exert teratogenic effects in the first 60 days following conception. Routine prenatal vitamin A supplementation for the prevention of maternal and infant morbidity and mortality is not recommended; however, in regions where VAD is a public health issue, vitamin A supplementation is recommended to prevent night blindness. Given the importance of this topic and the lack of a complete, up-to-date review on vitamin A and pregnancy, an extensive review of the literature was conducted to identify conflicting or incomplete data on the topic as well as any gaps in existing data.

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Section: Vitamin a And Pregnancy: Importance And Effects Of Deficimentioning

confidence: 99%

Vitamin A and Pregnancy: A Narrative Review

et al. 2019

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“…Recently, it has been described that maternal VAD affects foetal pancreatic islet vascularization and development and that retinoids are needed also by the adult to assure normal pancreatic endocrine functions, especially those of the α- and β-cells. VAD affects pancreatic progress and function causing apoptosis of pancreatic beta-cell masses which can be reverted by RA administration [ 102 , 103 , 104 ]. Also, altered retinoid signalling has profound effects on several physiological and pathological processes in the brain.…”

Section: Vitamin a Deficiencymentioning

confidence: 99%

Vitamin A Deficiency and the Lung

et al. 2018

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Vitamin A (all-trans-retinol) is a fat-soluble micronutrient which together with its natural derivatives and synthetic analogues constitutes the group of retinoids. They are involved in a wide range of physiological processes such as embryonic development, vision, immunity and cellular differentiation and proliferation. Retinoic acid (RA) is the main active form of vitamin A and multiple genes respond to RA signalling through transcriptional and non-transcriptional mechanisms. Vitamin A deficiency (VAD) is a remarkable public health problem. An adequate vitamin A intake is required in early lung development, alveolar formation, tissue maintenance and regeneration. In fact, chronic VAD has been associated with histopathological changes in the pulmonary epithelial lining that disrupt the normal lung physiology predisposing to severe tissue dysfunction and respiratory diseases. In addition, there are important alterations of the structure and composition of extracellular matrix with thickening of the alveolar basement membrane and ectopic deposition of collagen I. In this review, we show our recent findings on the modification of cell-junction proteins in VAD lungs, summarize up-to-date information related to the effects of chronic VAD in the impairment of lung physiology and pulmonary disease which represent a major global health problem and provide an overview of possible pathways involved.

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“…Deficiencies in VA, along with other folate and total energy, were associated with negative outcomes on kidney structure and function using outcomes of kidney volume, proteinuria, glomerular filtration rate, and creatinine clearance ( 146 ). Mouse model investigations of embryological development have provided evidence that maternal VAD can inhibit normal fetal pancreatic ( 147 ) and anorectal ( 148 ) development in utero. In a rat model investigating maternal VAD and perinatal organ growth, neonates born to VA-moderate mothers (rats whose VA concentrations were reduced ∼50%) expressed lower levels of proteins associated with skeletal muscle development, compared with the offspring of VA-sufficient mothers ( 149 ).…”

Section: Resultsmentioning

confidence: 99%

Vitamin A Requirements in Pregnancy and Lactation

Gannon

Jones

Mehta

2020

Current Developments in Nutrition

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Pregnancy and lactation are critical life stages with unique nutritional requirements, including for vitamin A (VA). Current Dietary Reference Intakes (DRIs) for VA were published in 2001. The objective of this review was to identify and categorize evidence related to VA requirements in pregnancy and lactation since these DRIs were formulated. We searched MEDLINE and included articles according to an analytic framework of maternal VA exposure on status and health outcomes in the mother-child dyad. Intermediate and indirect evidence supports that maternal VA intakes can impact the mother's VA status, breastmilk, and health outcomes, as well as the child's VA status and select health outcomes. Food-based approaches may lead to more sustained, sufficient VA status in mothers and children. Research needs include further study linking maternal VA intakes on maternal and child VA status, and further associations with outcomes to determine intake requirements to optimize health.

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Maternal vitamin A deficiency during pregnancy affects vascularized islet development

Cited by 15 publications

References 50 publications

Vitamin A and Pregnancy: A Narrative Review

Vitamin A and Pregnancy: A Narrative Review

Vitamin A Deficiency and the Lung

Vitamin A Requirements in Pregnancy and Lactation

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