Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

Miliku, Kozeta; Vinkhuyzen, Anna A. E.; Blanken, Laura M. E.; McGrath, John J.; Eyles, Darryl W.; Burne, Thomas H. J.; Hofman, Albert; Tiemeier, Henning; Steegers, Eric A.P.; Gaillard, Romy; Jaddoe, Vincent W. V.

doi:10.3945/ajcn.115.123752

Cited by 145 publications

(128 citation statements)

References 56 publications

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“…6 In one cohort in the Netherlands, 53.2% had circulating 25 hydroxyvitamin D 25-OHD concentration < 50 nmol/L, and 26.1% had concentration <25 nmol/L; 7 and in a recent multiethnic cohort study in Norway, 45% of South Asian, 40% of Middle Eastern and 26% of Sub-Saharan African pregnant women had circulating 25-OHD <25 nmol/L. 8 In a survey of Asian subjects, 77.3% had circulating 25-OHD concentration < 50 nmol/L, and 28.6% had concentration <25 nmol/L.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Zhou

Tao

Huang

et al. 2017

J of Obstet and Gynaecol

111

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Aim: We performed a meta-analysis of randomized controlled trials (RCT) and observational studies to answer the two following questions: (i) whether low maternal circulating 25 hydroxyvitamin D (25-OHD) is associated with an increased risk of preterm birth (PTB) or spontaneous PTB (sPTB); and (ii) whether vitamin D supplementation alone during pregnancy can reduce the risk of PTB. Methods: Literature search was carried out using Pubmed, Web of Science and Embase databases up to June 2016. Pooled OR or relative risk (RR) with 95%CI were computed using fixed or random effects models depending on the size of heterogeneity. Subgroup analysis was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Egger's test and Begg's test. Results: Twenty-four articles (six RCT and 18 observational studies) were identified. Maternal circulating 25-OHD deficiency (pooled OR, 1.25; 95%CI: 1.13-1.38) rather than insufficiency (pooled OR, 1.09; 95%CI: 0.89-1.35) was associated with an increased risk of PTB, and vitamin D supplementation alone during pregnancy could reduce the risk of PTB (pooled RR, 0.57; 95%CI: 0.36-0.91). This was also the case for the sPTB subgroup (circulating 25-OHD <50 vs >50 nmol/L; pooled OR, 1.45; 95%CI: 1.20-1.75). Conclusions: Maternal circulating 25-OHD deficiency could increase PTB risk and vitamin D supplementation alone during pregnancy could reduce PTB risk. Extrapolation of the results, however, must be done with caution, and there is urgent need for larger, better-designed RCT to confirm this effect.

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Section: Introductionmentioning

confidence: 99%

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Zhou

Tao

Huang

et al. 2017

J of Obstet and Gynaecol

111

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“…A total of 1639 were excluded after reading titles and/or abstracts, and 75 articles were subjected to a full-text review. After reading the full text, a total of 24 cohorts were invited to participate, which included 13 cohort studies [27][28][29][30][31][32][33][34][35][36][37][38][39], seven case-control studies [40][41][42][43][44][45][46] and four cross-sectional studies [47][48][49][50].…”

Section: Search Resultsmentioning

confidence: 99%

“…Because three studies [29][30][31] of 24 measured serum 25(OH)D concentrations at two or three periods of pregnancies, our meta-analysis included nine studies [28][29][30][31]36,39,41,44,46] in the first trimester, 11 studies [27,[30][31][32][33][34][35]37,38,40,43] in the second trimester, and nine studies [29][30][31]42,45,[47][48][49][50] in the third trimester.…”

Section: Search Resultsmentioning

confidence: 99%

“…Five of all studies included showed that lower 25(OH)D levels in middle pregnancy are associated with preterm birth, and even that there is a protective association between maternal vitamin D sufficiency and preterm birth [30,34,38,40,43]. Kassai et al's study shows that mothers who delivered preterm babies had lower 25(OH)D concentrations prior to delivery compared to women who had given birth at the full-term of their pregnancy [47].…”

Section: Discussionmentioning

confidence: 99%

“…The included studies from the United States, Canada, Australia, New Zealand, Spain, Netherlands, Swedish, Poland, Brazil, Kenya, China, Singapore and Thailand. A total of nine studies [28,30,31,33,37,40,[48][49][50] were from Asian countries, six [36,41,43,[45][46][47] from American countries, five [29,34,38,39,42] from European countries, three [27,35,44] from Oceanian countries, and one [32] was from African countries. Among 24 studies, 21 [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] cohort studies or case-control studies were appraised by NOS, resulting with scores above 6, while four [47][48][49][50] cross-sectional studies were appr...…”

Section: Study Characteristicsmentioning

confidence: 99%

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Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Lian

et al. 2020

Preprint

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Background: Current studies suggest that vitamin D deficiency during pregnancy can produce a certain effect for preterm birth, but there is no research showing whether vitamin D deficiency has a consistent effect in different pregnancies; thus, we conducted a systematic review and meta-analysis of 24 observational studies, grouping them according to the gestational age at the time of serum sampling, to investigate whether vitamin D deficiency in different periods of gestation has different effects on preterm birth and to provide an evidence-based basis for pregnant women to measure and supplement vitamin D. Methods: The databases PubMed-Medline, EMBASE, the Cochrane Library, Web of Science, EBSCO, CBM, and CNKI were searched until July 2019. Two researchers independently assessed the eligibility and quality of studies, and STATA 12.0 software was used for meta-analysis. Result: Seven cohort studies, 13 case-control studies, and four cross-sectional studies were included from 2500 articles by inclusion and exclusion criteria. After adjusting for age, race, and other confounding factors, meta-analysis results showed that vitamin D deficiency in the first trimester, the second trimester and the third trimester did not increase the risk of preterm birth (odds ratio (OR) = 1.01, 95% confidence interval (CI) (0.88, 1.16), P = 0.867; OR = 1.12, 95%CI (0.92, 1.37), P = 0.249; OR = 1.05, 95%CI (0.87, 1.27), P = 0.602). However, there was moderate heterogeneity in the study of vitamin D deficiency in the second trimester, and subgroup analysis suggested that vitamin D deficiency in the second trimester may increase the risk of preterm birth (OR = 1.33, 95%CI (1.15, 1.54), P = 0.000). A sensitivity analysis of the second trimester showed that excluding any one study did not significantly change the results. Conclusions: Vitamin D deficiency in early and late pregnancy may not be associated with preterm birth, while vitamin D deficiency in middle pregnancy is likely to have an important effect on preterm birth. Vitamin D levels should be measured in the second trimester of pregnancy, and vitamin D supplements should be provided if necessary.

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Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study

Adrien

Orta

Nestoridi

et al. 2022

Birth Defects Research

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Introduction: Vitamin D deficiency is associated with adverse pregnancy events. However, its role in the etiology of congenital anomalies remains unclear. We examined the association between vitamin D status, measured through prepregnancy diet, UV exposure, season of conception, and congenital anomalies. Methods: We used data from the National Birth Defects Prevention Study, a U.S. population-based case-control study (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011). Prepregnancy dietary vitamin D was calculated from food frequency questionnaires and evaluated using tertiles, based on the distribution in controls. We used the National Oceanic and Atmospheric Administration Weather Service to assign UV indices based on location and estimated date of conception, then dichotomized UV exposure (low vs. high). Seasons of conception was categorized as fall/winter spring/summer. We used logistic regression to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI). Results: Lower prepregnancy dietary vitamin D intake (<65.21 IU/d vs. >107.55 IU/d) was associated with increased odds of anencephaly (aOR = 1.28, 95% CI 1.01, 1.63), hypospadias (aOR = 1.21, 95% CI 1.04, 1.40), septal defects (aOR = 1.16, 95% CI 1.05, 1.30), diaphragmatic hernia (aOR = 1.42, 95% CI 1.13, 1.79), and gastroschisis (aOR = 1.27, 95% CI 1.07, 1.52). Findings were consistent when we stratified by UV exposure and season of conception. Conclusions: Our findings suggest lower dietary intake of vitamin D may be associated with increased risk of select congenital anomalies. Further investigations are warranted to evaluate the effects of other nutrients and appropriate thresholds and sources of vitamin D using serum.

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Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

Cited by 145 publications

References 56 publications

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study

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