Maternal vs paternal diabetes: The parental history is different in younger onset versus older onset type 2 diabetes

Middleton, Tim; Brooks, Belinda; Constantino, Maria; Wu, Ted; Wong, Jencia; Yue, Dennis K.

doi:10.1016/j.jdiacomp.2019.107440

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Further, our study identified a higher association of family history of diabetes with prevalence of diabetes for individuals who reported a father with diabetes compared with those who reported a mother with diabetes (OR, 4.49 versus 3.96), as well as for family history of coronary artery disease with prevalence of coronary artery disease (OR, 4.20 versus 3.56) whereas prior studies have identified a stronger maternal effect. 63 , 64 These differences in the magnitude of association from prior works may be due to the incomplete inclusion of risk factors or due to true differences found in a diverse but not nationally representative sample.…”

Section: Discussionmentioning

confidence: 96%

Association Between a First‐Degree Family History and Self‐Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program

Rasooly,

Moonesinghe,

Littrell

et al. 2023

JAHA

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Background Family history reflects the complex interplay of genetic susceptibility and shared environmental exposures and is an important risk factor for obesity, diabetes, and heart and blood conditions (ODHB). However, the overlap in family history associations between various ODHBs has not been quantified. Methods and Results We assessed the association between a self‐reported family history of ODHBs and their risk in the adult population (age ≥20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history‐wide association study to systematically assess the association of a first‐degree family history of 15 ODHBs in AoU. We performed stratified analyses based on racial and ethnic categories, education, household income and gender minority status, and quantified associations by type of affected relatives. Of 125 430 participants, 76.8% reported a first‐degree family history of any ODHB, most commonly hypertension (n=64 982, 51.8%), high cholesterol (49 753, 39.7%), and heart attack (29 618, 23.6%). We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB. Conclusions Our findings inform the utility of family history data as a risk assessment and screening tool for the prevention of ODHBs and to provide additional insights into shared risk factors and pathogenic mechanisms.

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Section: Discussionmentioning

confidence: 96%