Mathematical modeling and analysis of anemia during pregnancy and postpartum

Daud, Auni Aslah Mat; Toh, Cher Qing; Saidun, Salilah

doi:10.1007/s12064-020-00334-2

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“…Известно, что с прогрессированием гестационного срока частота дефицита железа в организме матери возрастает в 3-3,5 раза [8]. К факторам, предрасполагаю щим к возникновению данного состояния, относятся: истощенные запасы микроэлемента у 40-60% женщин во время беременности, интенсификация эритропоэза, увеличение эритроцитарной массы, потребление плодом железа из материнского депо, вследствие которого у матери формируется его отрицательный баланс [9,10].…”

Section: Introductionunclassified

Effective preconception preparation for women with iron deficiency

et al. 2023

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Introduction. Latent iron deficiency, which has a high prevalence among women of childbearing age, most often, in the absence of therapy, progresses in pregnant women into manifest iron deficiency, manifested by clinical symptoms of anemia and associated with a complicated course of pregnancy, childbirth, the postpartum period, unfavorable outcomes of newborns. The above justifies the need for correction of iron deficiency at the preconception period.Aim. To evaluate the effectiveness of therapy latent iron deficiency at the stage of preconception period.Materials and methods. The study included 32 women at the stage of pregnancy planning with latent iron deficiency. All women taking the drug Ferretab 1 pill per day for 1 month. The level of blood parameters was assessed at 3 months before the intended conception, in the I, II and III trimesters of pregnancy, in the 3rd day after delivery. In newborns, the indicators of a clinical blood test were evaluated on the 2nd day after birth. We evaluated such indicators as the level of hemoglobin, erythrocytes, hematocrit, the average content of hemoglobin in erythrocytes, serum ferritin, serum iron, transferrin.Results. Evaluation of laboratory data in the course of the study confirmed the effectiveness of the use the complex drug Ferretab. Patients already at the first visit to the doctor during pregnancy had a positive trend and a significant increase in the level of hematological parameters.Conclusions. Oral administration of the complex drug Ferretab showed high efficiency in the treatment of latent iron deficiency at the stage of preconception period, significantly increasing the levels of hematological parameters, good tolerance and a small number of side effects, contribute to the high adherence of patients to therapy, which allows achieving significant clinical results.

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Section: Introductionunclassified