Mathematical Models for the Differential Diagnosis of Various Forms of Pyelonephritis by Expert Systems in Urology

Korenevskiy, Nikolay; Siplivyi, G. V.; Rodionov, D. S.; Govorukhina, T. N.; Dmitrieva, V. V.

doi:10.1007/s10527-020-09960-y

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“…In this study, we investigated the relationship between the levels of MMP-9 and TGF beta 1 in the kidney during the pathogenesis of pyelonephritis and their roles in the development of renal injury by establishing a rat model of acute pyelonephritis, which provides new ideas, methods, and techniques to explore the mechanisms of pyelonephritis and immune injury [10][11][12][13][14][15] . Main results: (1) 10 μg/mL of E. coli was injected intraperitoneally into rats every 3 days for 7 days, with no deaths or abnormalities during the process of infection.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Transforming Growth Factor Beta 1 Levels in Escherichia coli-Infected Rats with Acute Pyelonephritis

Tian

et al. 2023

JCNR

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Objective: To investigate the expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and transforming growth factor beta 1 (TGF beta 1) in the kidney tissue of rats with pyelonephritis and their relationship with pyelonephritis by establishing a rat model of acute pyelonephritis. Methods: 80 male Wistar rats were randomly divided into a control group and an experimental group, with 40 rats each. The rats of the control group were injected with and saline and those of the experimental group were injected with 10 ?g/mL Escherichia coli (E. coli) and saline (1:100); the solutions for both groups were administered every 3 days for 7 days. The expressions of MMP-2, MMP-9 and TGF beta 1 in the kidney tissues of rats in each group were observed. Results: The expression of MMP-9 and TGF beta 1in the kidney tissue of rat acute pyelonephritis model rats was significantly higher than those of the control group (P < 0.01); the MMP-9 mRNA content in the kidney tissue of the experimental group was significantly higher than that of the control group (P < 0.05); the TGF beta 1 mRNA content in the renal tissue of the experimental group increased significantly compared to the (P < 0.05); MMP-2, MMP-9 and TGF beta 1 began to express in the early stage of pyelonephritis until the complete formation of renal pelvic edema. The difference between groups was statistically significant (P < 0.01). Conclusion: MMP-9 and TGF beta 1 are important factors regulating renal tubular epithelial cell injury and inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Transforming Growth Factor Beta 1 Levels in Escherichia coli-Infected Rats with Acute Pyelonephritis

Tian

et al. 2023

JCNR

View full text Add to dashboard Cite

show abstract

Mathematical Models for the Differential Diagnosis of Various Forms of Pyelonephritis by Expert Systems in Urology

Cited by 1 publication

References 2 publications

Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Transforming Growth Factor Beta 1 Levels in Escherichia coli-Infected Rats with Acute Pyelonephritis

Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Transforming Growth Factor Beta 1 Levels in Escherichia coli-Infected Rats with Acute Pyelonephritis

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