Mathematical simulation of the structure of pulsed arterial pressure relations with vascular damage factors in patients with arterial hypertension

Vysotska, Olena; Bespalov, Yurii; Pecherska, Anna; Koval, S.M.; Lytvynova, Olga; Dyvak, A.M.; Maciejewski, Marek; Kalizhanova, Aliya

doi:10.1201/9780429057618-7

Cited by 3 publications

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“…Одним із прогностично несприятливих проявів ураження органів-мішеней при АГ та в разі поєднання АГ з ЦД 2-го типу і ожирінням є гіпертрофія міокарда лівого шлуночка серця (ГЛШ) з подальшим розвитком патологічної перебудови лівого шлуночка та формуванням його діастолічної дисфункції [1,6]. В основі цих ускладнень лежать процеси гіпертрофії кардіоміоцитів та фіброзування міокарда, які у хворих на АГ з ЦД 2-го типу і ожирінням активуються під впливом як гемодинамічних, нейрогуморальних, молекулярно-генетичних чинників, характерних для АГ [7][8][9], так і метаболічних порушень, які найбільш яскраво виражені при ЦД 2-го типу й ожирінні (гіперглікемія, інсулінорезистентність, патологічна гліоксилація білків та ін.) [5,10].…”

Section: вступunclassified

Динамика Ремоделирования Левого Желудочка У Больных Артериальной Гипертензией С Сахарным Диабетом 2-Го Типа И Ожирением Под Влиянием Одногодичной Комбинированной Терапии

Koval

Starchenko

Yushko

et al. 2021

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Актуальность. Патологическое ремоделирование левого желудочка (ЛЖ) у больных артериальной гипертензией (АГ) с сахарным диабетом (СД) 2-го типа и ожирением ассоциируется со значительным повышением сердечно-сосудистого риска и требует ранней и адекватной медикаментозной коррекции. Материалы и методы. В исследование включены 38 больных АГ 2-й степени с субкомпенсированным СД 2-го типа и абдоминальным ожирением (АО). Обследование проводили до и после одногодичной терапии блокатором рецепторов ангиотензина ІІ олмесартаном и антагонистом кальция лерканидипином в сочетании с аторвастатином и метформином. Результаты. У больных выявлена высокая частота патологических типов ремоделирования ЛЖ (концентрическая и эксцентрическая гипертрофия ЛЖ (ГЛЖ) (50 и 37 % соответственно) с развитием его диастолической дисфункции в 89 % случаев. Комбинированная терапия способствовала достоверному снижению выраженности ГЛЖ и частоты диастолической дисфункции. Выводы. Длительное применение олмесартана и лерканидипина в сочетании с аторвастатином и метформином у больных АГ с СД 2-го типа и АО является эффективным методом торможения прогрессирования патологического ремоделирования ЛЖ.

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Section: вступunclassified

Динамика Ремоделирования Левого Желудочка У Больных Артериальной Гипертензией С Сахарным Диабетом 2-Го Типа И Ожирением Под Влиянием Одногодичной Комбинированной Терапии

Koval

Starchenko

Yushko

et al. 2021

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“…The published patents [1,2] describe electronic methods and means for diagnosing disorders of the functional and physiological state of people. Descriptions of approaches to research and mathematical modeling of diagnostic processes of metabolic imbalance [3], myocardial infarction [4], obesity [5], hypertension [6] are also available. The solutions given in these works allow creating diagnostic complexes to identify local disorders in the body, but do not give a holistic view of health.…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

“…For the transition from functional to elementary structures, it is advisable to use a universal modeling unit -information invariant, which reflects the target and forced transformations: (6) Here:…”

Section: Definition Of Common Sets Of Structural Solutions Using Infomentioning

confidence: 99%

“…Further improvement of the complex by increasing its energy efficiency and quality can be carried out on the basis of technical audit. The algorithm of system technical audit can be based on the use of the general model of the target transformations arising in the interaction of the converting and converted systems according to the model (6). The audit determines the total energy consumption per unit of output and quality of the system.…”

Section: Optimization and Technical Audit Of The Complexmentioning

confidence: 99%

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Development of the method of structural and parametric synthesis of the Quanton diagnostic and health complex

Ogorodnyk¹,

Vуsotska

Ternyuk³

et al. 2019

EEJET

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“…Unfortunately, double and triple combined anti-hypertensive therapy did not correspond to achieve target level of BP in many cases in patients with AO 14 . Previous studies have shown that more than half of patients needed double therapies to achieve full control in BP, while 20-30% of patients required triple combination and ever more [15][16][17] . It has been postulated that poor adherence to antihypertensive treatment, respectively high frequency of adverse effects and low tolerability could be the main causes to withdraw from the therapy 18 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fixed dose of triple combination of perindopril-indapamide-amlodipine in obese patients with moderate-to-severe arterial hypertension: an open-label 6-month study

et al. 2019

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Background: Arterial hypertension (AH) remains the most common cardiovascular (CV) risk factor worldwide. Methods: Seventy five moderate-to-severe hypertensive patients with abdominal obesity aged from 48 to 66 years (45/30 men and women respectively) were selected from the entire cohort (n = 375) according to the inclusion and exclusion criteria. The patients were divided into two subgroups depending on the arm of antihypertensive therapy lines. The first subgroup of patients (n = 36) received a non-fixed combination of oral antihypertensive agents: perindopril (4-8 mg daily), indapamide (1.25-2.5 mg daily) and amlodopine (5-10 mg daily). The second subgroup of patients (n=39) received fixed-dosed combination of these antihypertensive agents aforementioned in the ranged doses (4 mg/1.25mg/5 mg; 4 mg/1.25mg/10 mg; 8 mg/2.5 mg/5 mg; 8 mg/2.5mg/10 mg) in the same manner. The examinations of the clinical status, office, and ambulatory blood pressure values were carried out at baseline in 3 and 6 months after study entry. Results: The frequencies of BP target levels after treatment were higher in the fixed-dose combination group than in the non-fixed combination (at 3 months: 80% versus 58%, p<0.05 and at 6 months: 85% versus 53%, p<0.05). The adherence to triple fixed-dose combination was also higher in comparison with one to non-fixed combination (at 3 months: 82% versus 64%, p<0.05 and at 6 months: 87% versus 61%, p<0.05). It has been established that low-dose of perindopril/indapamide/amlodopine (4mg/1.25/10mg and 8mg/2.5/5mg) were used frequently in fixed-dose combination cohort of patients than in non-fixed combination (15% versus 0%, P<0.05, and 33% versus 19%, p<0.05, respectively). At the same time, maximum doses of these agents (8mg/2.5mg/10mg) were required for achieving target BP levels in a significantly lower proportion of patients receiving fixed-dose combination as compared to patients receiving non-fixed combination (52% versus 81%, p<0.05). Additionally, the triple fixed-dose combination has proved to be better in restoring ambulatory blood pressure monitoring profile than non-fixed combination. Conclusion: Achievement of target blood pressure levels in patients with uncontrolled arterial hypertension and abdominal obesity was possible at lower doses of perindopril, indapamide, and amlodipine when used as a fixed-dose combination rather than non-fixed (free) combination. Key words: abdominal obesity, antihypertensive therapy, arterial hypertension, fixed-dose combination of antihypertensive agents, non-fixed combination of antihypertensive agents Cite this article : Koval S M, Snihurska I O, Starchenko T G, Penkova M Y, Mysnychenko O V, Yushko K O, Lytvynova O M, Vysotska O, Berezin A E. Efficacy of fixed dose of triple combination of perindoprilindapamide-amlodipine in obese patients with moderate-to-severe arterial hypertension: an open-label 6-month study. Biomed. Res. Ther.; 6(11):3501-3512. 3501 History •

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Mathematical simulation of the structure of pulsed arterial pressure relations with vascular damage factors in patients with arterial hypertension

Cited by 3 publications

References 1 publication

Development of the method of structural and parametric synthesis of the Quanton diagnostic and health complex

Efficacy of fixed dose of triple combination of perindopril-indapamide-amlodipine in obese patients with moderate-to-severe arterial hypertension: an open-label 6-month study

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