Matrisome gene expression is altered during non-allometric heart growth in genetically enlargedDrosophila
Rachel M. Andrews,
J. Roger Jacobs
Abstract:The cardiac extracellular matrix (ECM) is critical to defining the biophysical properties of the heart that adapt to changing stresses with growth or disease. The ECM is commonly dysregulated in chronic disease such as hypertension, diabetes, and cardiomyopathies, often leading to the development of fibrosis. There are no treatment options to address most ECM cardiomyopathies, but developing therapeutic targets necessitates an understanding of the regulation of ECM remodelling. Here, we employ a larvalDrosophi… Show more
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