Matrix‐assisted laser desorption/Ionization coupled to Fourier transform ion cyclotron resonance mass spectrometry: a method to characterize temoporpfin photoproducts

Angotti, Marc; Maunit, Benoı̂t; Müller, Jean-François; Bezdetnaya, Lina; Guillemin, François

doi:10.1002/(sici)1097-0231(19990415)13:7<597::aid-rcm528>3.3.co;2-1

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Qualitative Characterization Of Lmw Compounds1

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2002

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“…Adducts of monomeric melanin dopaquinone (DOPAQ) with nicotine and cotinine were determined and compared to DOPAQ adducts with deuterated analogues of nicotine and cotinine [36]. Not surprisingly, a logical pharmaceutical application of MALDI has been in the realm of phototherapy, although only two systems have been investigated; tempoporpfin, a tumor localizing photosensitizer [37], and a dye-dendrimer complex, pheophorbide-α-substituted diaminobutane polypropyleneimine [38].…”

Section: Qualitative Characterization Of Lmw Compoundsmentioning

confidence: 99%

Small molecule analysis by MALDI mass spectrometry

2002

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This review focuses on the application of matrix assisted laser desorption/ionization (MALDI) mass spectrometry to the characterization of molecules in the low mass range (<1500 Da). Despite its reputation to the contrary, MALDI is a powerful technique to provide both qualitative and quantitative determination of low molecular weight compounds. Several approaches to minimize interference via sample preparation and matrix selection are discussed, as well as coupling of MALDI to liquid and planar chromatographic techniques to extend its range of applicability.

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Section: Qualitative Characterization Of Lmw Compoundsmentioning

confidence: 99%