Matrix effect in bioanalytical assay development using supercritical fluid chromatography‐mass spectrometry
Liuxi Chen,
Yuxiang Cui,
Brian Dean
et al.
Abstract:Matrix effect (ME) is commonly caused by coelution of compounds with target analytes, resulting in either suppression or enhancement of analyte ionization. Thus, to achieve the desired accuracy, precision, and sensitivity, ME needs to be evaluated and controlled during bioanalytical method development. As the application of supercritical fluid chromatography‐mass spectrometry (SFC‐MS) for analysis of biological samples has increased, ME using SFC‐MS has also been investigated with a focus on the difference in … Show more
“…6,7 Hence, methods for the determination of these bioanalytes should have high sensitivity of detection in low sample volumes and, if possible, should be tolerant towards matrix effects. 8–10…”
This review summarizes recent developments in amperometric biosensors based on one-step electrodeposited organic-inorganic hybrid layers and used for analysis of low molecular weight compounds. The factors affecting self-assembly of one-step...
“…6,7 Hence, methods for the determination of these bioanalytes should have high sensitivity of detection in low sample volumes and, if possible, should be tolerant towards matrix effects. 8–10…”
This review summarizes recent developments in amperometric biosensors based on one-step electrodeposited organic-inorganic hybrid layers and used for analysis of low molecular weight compounds. The factors affecting self-assembly of one-step...
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