Matrix for Mucosal Regeneration in Transoral Glossectomy for Squamous Cell Carcinoma: Objective and Subjective Functional Evaluation

Abstract

Background: Numerous options to manage local reconstruction following transoral partial glossectomy are possible. In this work, we present our experience using a matrix for mucosal regeneration, IntegraÒ, after transoral resections of squamous cell carcinoma of the oral tongue. Methods: A retrospective analysis of patients treated for tongue carcinoma and reconstruction with IntegraÒ, from September 2017 to September 2022. Functional outcomes were evaluated by measuring swallowing and speech abilities, tongue motility, and subjective quality of life. Results: The series accounts for 13 consecutive patients, staged from Tis to T3, no positive resection margins were found, average defect size was 17.8 cm2. The average histologically measured depth of invasion was 4.1 mm (range 2–12 mm), and no recurrences were observed during follow-up. All patients maintained excellent swallowing function, the average number of recognized words by an external listener during a phone call was 70.5 out of 75, the lingual motility test was good (a mean score of 4.5 out of 6 movements correctly executed) and subjective questionnaires results were optimal. Less satisfying functional results were recorded in elderly patients receiving a wider surgical resection. Conclusions: This reconstructive technique for allows obtaining optimal healing and functional outcomes in patients with tumors suitable for transoral glossectomy.

Current and Future Developments in Wound Healing

“…Bioengineered skin substitutes have also been increasingly used to overcome the disadvantages of skin grafting and associated donor site morbidity. Current applications for tissue substitutes in the head and neck literature include reconstruction of large scalp 33,34 and face/temporal region defects, radial forearm free flap donor site coverage, 35 nasal reconstruction, [36][37][38] and intraoral mucosal (buccal mucosa, floor of mouth, and lateral/ventral tongue) reconstruction 39,40 after oncologic resection. Use of Integra bilayer wound matrix (Integra LifeSciences, Plainsboro, NJ) has been described as a reasonable reconstructive solution for denuded avascular wounds including irradiated tissue, bare calvarial bone (►Fig.…”