Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells

“…However, there are still significant obstacles in the way of developing stem cell therapies, including the high operation costs, complicated cell expansion procedures and uncontrolled differentiation of transplanted stem cells 10 . In addition, the uses of MSCs are restricted to exogenous stem cell injections and this approach has several drawbacks, including a poor stem cell survival rate and rejection 11,12 . Therefore, cell homing‐based treatment by recruiting endogenous MSCs to the injury site and maintaining chondrogenesis has recently offered a new way for tissue regeneration in situ 13,14 .…”

“… 10 In addition, the uses of MSCs are restricted to exogenous stem cell injections and this approach has several drawbacks, including a poor stem cell survival rate and rejection. 11 , 12 Therefore, cell homing‐based treatment by recruiting endogenous MSCs to the injury site and maintaining chondrogenesis has recently offered a new way for tissue regeneration in situ. 13 , 14 The primary and widely recognized treatment, known as MF, is intended to recruit endogenous mesenchymal stem cells (MSCs) from the bone marrow for articular cartilage repair.…”

Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

“…For instance, contraction of the dermal sheath drives stem cells to regenerate the tissue structure [ 9 , 10 ] whereas mesenchymal stem cells promote skin regeneration accelerating tissue expansion [ 11 , 12 ]. These reports suggest that dynamic control of the inflation and deflation of ECM-emulating ligand assemblies can help to decipher and regulate the dynamic interplay between stem cells [ [13] , [14] , [15] , [16] ] and the assembled ligands [ [17] , [18] , [19] , [20] , [21] ].…”

Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair

“…[9][10][11][12][13][14] In an attempt to explore a proper strategy for cartilage repair, various functional tissue-engineering biomaterials have been developed. [15][16][17][18][19][20] Specifically, hydrogels derived from natural polymers, such as collagen, alginate and chitosan, have been widely applied for defect-filling treatment due to their 3D aqueous network architectures, excellent biocompatibility and biodegradability. [21][22][23][24] Moreover, stimuli-responsive hydrogels, including temperature-, pH-and enzyme-responsive hydrogels, have been developed for better tissue regeneration.…”

“…9–14 In an attempt to explore a proper strategy for cartilage repair, various functional tissue-engineering biomaterials have been developed. 15–20…”