Matrix metalloprotease activity shapes the magnitude of EPSPs and spike plasticity within the hippocampal CA3 network

Wójtowicz, T.; Mozrzymas, Jerzy W.

doi:10.1002/hipo.22205

Cited by 32 publications

(55 citation statements)

References 89 publications

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“…Extracellular molecules and matrix metalloproteinases (MMPS) are involved in remodelling the pericellular environment and acting as a modulator of inflammation. Similarly to contextual learning, MMPS are involved with psychostimulant behavioural sensitization and synapse activity and plasticity (Mizoguchi et al, 2008;Wójtowicz & Mozrzymas, 2014). A possible neural A c c e p t e d M a n u s c r i p t 9 pathway involved in peripheral inflammatory signalling may be the activation of the afferent Vagus nerve, resulting in activation of the solitary tracts and the bed nucleus of the stria terminalis (BNST).…”

mentioning

confidence: 99%

Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression

Tortorelli

Engelke

Lunardi

et al. 2015

Behavioural Brain Research

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mentioning

confidence: 99%

Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression

Tortorelli

Engelke

Lunardi

et al. 2015

Behavioural Brain Research

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“…Acute brain slices were prepared as described previously [17]. All of the experimental procedures were approved by the Local Ethics Committee.…”

Section: Methodsmentioning

confidence: 99%

“…1a). NMDAR-mediated signals were isolated with the AMPA/kainate receptor antagonist DNQX (20 μM) and l -type calcium channel blocker nifedipine (20 μM) in Mg 2+ -free solutions, as described previously [17]. At the end of each recording, the NMDAR antagonist APV (50 μM) was used to confirm the origin of the recorded fEPSP NMDA .…”

Section: Methodsmentioning

confidence: 99%

“…Linear peptide GRGDSP was purchased from Proteogenix (France). The electrophysiology data were analyzed using pClamp10.3 software (Molecular Devices, USA) and AxoGraphX software (developed by John Clements) as described previously [17].

Fig.…”

Section: Methodsmentioning

confidence: 99%

“…In addition to modulating synaptic plasticity, a recent study found that acute and long-term extracellular proteolysis affected long-term neuronal excitability [10]. We recently found that the activity of certain MMP subtypes may modulate long-term NMDAR function, and MMP-3 and MMP-2/9 inhibition differentially affected the time course of E-S potentiation [17]. In the present study, we investigated the temporal relationships between the activity of these MMP subtypes, NMDAR function, and E-S potentiation in the CA1 region of the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

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Matrix Metalloprotease 3 Activity Supports Hippocampal EPSP-to-Spike Plasticity Following Patterned Neuronal Activity via the Regulation of NMDAR Function and Calcium Flux

et al. 2016

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Matrix metalloproteases (MMPs) comprise a family of endopeptidases that are involved in remodeling the extracellular matrix and play a critical role in learning and memory. At least 24 different MMP subtypes have been identified in the human brain, but less is known about the subtype-specific actions of MMP on neuronal plasticity. The long-term potentiation (LTP) of excitatory synaptic transmission and scaling of dendritic and somatic neuronal excitability are considered substrates of memory storage. We previously found that MMP-3 and MMP-2/9 may be differentially involved in shaping the induction and expression of excitatory postsynaptic potential (EPSP)-to-spike (E-S) potentiation in hippocampal brain slices. MMP-3 and MMP-2/9 proteolysis was previously shown to affect the integrity or mobility of synaptic N-methyl-d-aspartate receptors (NMDARs) in vitro. However, the functional outcome of such MMP-NMDAR interactions remains largely unknown. The present study investigated the role of these MMP subtypes in E-S plasticity and NMDAR function in mouse hippocampal acute brain slices. The temporal requirement for MMP-3/NMDAR activity in E-S potentiation within the CA1 field largely overlapped, and MMP-3 but not MMP-2/9 activity was crucial for the gain-of-function of NMDARs following LTP induction. Functional changes in E-S plasticity following MMP-3 inhibition largely correlated with the expression of cFos protein, a marker of activity-related gene transcription. Recombinant MMP-3 promoted a gain in NMDAR-mediated field potentials and somatodendritic Ca2+ waves. These results suggest that long-term hippocampal E-S potentiation requires transient MMP-3 activity that promotes NMDAR-mediated postsynaptic Ca2+ entry that is vital for the activation of downstream signaling cascades and gene transcription.

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Exposure to 1-bromopropane vapors during pregnancy enhances the development of hippocampal neuronal excitability in rat pups during lactation

Fueta

Ueno

Ishidao

et al. 2020

Journal of Occupational Health

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Objectives Although 1‐Bromopropane (1‐BP) exposure has been reported to cause neurotoxicity in adult humans and animals, its effects on the development of the central nervous system remain unclear. Recently, we reported delayed developmental neurotoxicity (DNT) upon 1‐BP exposure in rats. Here we aimed to study the effect of prenatal 1‐BP exposure on the hippocampal excitability in the juvenile offspring. Methods Pregnant Wistar rats were exposed to vaporized 1‐BP for 20 days (6 h/d) with concentrations of 0 (control), 400, or 700 ppm. Hippocampal slices were prepared from male offspring during postnatal days (PNDs) 13, 14, and 15. Field excitatory postsynaptic potential (fEPSP) and population spike (PS) were recorded simultaneously from the CA1 region. Results In the exposed groups, the stimulation/response relationships of fEPSP slope and PS amplitude were enhanced more than in the control group at PND 14. Analysis of fEPSP‐spike coupling demonstrated increased values of Top and Eslope50 in the exposed groups. Real‐time PCR analysis showed a significant increase in the mRNA levels of the adult type Na v 1.1 Na + channel subunit and the GluR1 glutamate receptor subunit in the hippocampus of the 700 ppm group at PND 14. Conclusions Our results provide evidence that prenatal exposure to 1‐BP accelerates developmental enhancement of hippocampal excitability in the pups before eye‐opening. The current study suggests that our evaluation method of DNT is applicable to the industrial chemical 1‐BP.

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Matrix metalloprotease activity shapes the magnitude of EPSPs and spike plasticity within the hippocampal CA3 network

Cited by 32 publications

References 89 publications

Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression

Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression

Matrix Metalloprotease 3 Activity Supports Hippocampal EPSP-to-Spike Plasticity Following Patterned Neuronal Activity via the Regulation of NMDAR Function and Calcium Flux

Exposure to 1-bromopropane vapors during pregnancy enhances the development of hippocampal neuronal excitability in rat pups during lactation

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