Matrix metalloproteinase gene expression in oral lichen planus: erosive vs. reticular forms

Mazzarella, Nicoletta; Femiano, F; Gombos, F; Rosa, Alfredo De; Giuliano, Mariateresa

doi:10.1111/j.1468-3083.2006.01693.x

Cited by 39 publications

(30 citation statements)

References 26 publications

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“…15 The process from OLP to OSCC is complicated and regulated by many factors. 15 Erosive form is more susceptible than reticular to malignant transformation, Our results confirm this process well and support the earlier report by Mazzarella et al, 20 It may mean that if we screen the MMP-3 in OLP periodically, its rises may indicate a signal toward malignant transformation. This would be very important for both patients and clinician.…”

Section: Discussionsupporting

confidence: 92%

Serum and Saliva MMP-3 in Patients with OLP and Oral SCC

Agha‐Hosseini

Mirzaii‐Dizgah

Mahboobi

et al. 2015

The Journal of Contemporary Dental Practice

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Background: Matrix metalloproteinase-3 (MMP-3) plays a key role in development of cancer. The purpose of this study was to assess MMP-3 in the serum and saliva of patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Materials and methods:Thirty patients with OLP (8 reticular and 22 erosive forms), and 20 patients with OSCC (6 in low stage and 14 in advanced stage), were enrolled in this study, conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The serum and saliva MMP-3 was assayed by ELISA method. Statistical analysis of the Student's t-test, ANOVA and Pearson correlation coefficient was performed. The mean saliva and serum levels of MMP-3 were significantly higher in patients with OSCC compared with OLP. Results:The serum and saliva MMP-3 concentrations increased from reticular form of OLP to erosive form of OLP, and increased further to low stage of OSCC and advanced stage of OSCC. Serum MMP-3 correlated significantly with unstimulated (r = 0.310, p = 0.038) and stimulated (r = 0.365, p < 0.026) saliva MMP-3. Conclusion:Serum and saliva MMP-3 levels appear associated with OLP and OSCC.

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Section: Discussionsupporting

confidence: 92%

Serum and Saliva MMP-3 in Patients with OLP and Oral SCC

Agha‐Hosseini

Mirzaii‐Dizgah

Mahboobi

et al. 2015

The Journal of Contemporary Dental Practice

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“…it is still not generally accepted, that olp bears the malignant potential and these results might bring more understanding in malignant transformation of olp. on the other hand, Mazzarella et al (23) reported higher levels of MMp -9 in reticular olp than in erosive olp. erosive form of olp is however believed to be more aggressive variant of the disease.…”

Section: Resultsmentioning

confidence: 93%

Expression of Matrix Metalloproteinase 9 in Patients with Oral Lichen Planus

Paulusová

Laco

Drízhal

et al. 2012

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Introduction: Oral Lichen planus (OLP) is chronic inflammatory oral mucosal disease of unknown etiology. Basement membrane damage and t -cell migration in olp may be mediated by matrix metalloproteinases (MMps). we examined the expression of matrix metalloproteinase 9 to support this hypothesis. Materials and methods: the study population consisted of 71 patients with OLP and 10 control patients with oral fibromas. Indirect immunohistochemistry was used for detection of MMp 9 expression (polyclonal rabbit anti -human MMp antibody). Results: in all cases of olp, the MMP -9 expression was seen mainly in the area of lymphocytic inflammatory infiltrate in the lamina propria including lymphocytes within the overlying epithelium. in addition, it was observed in the epithelial keratinocytes, particularly in the stratum basale and stratum spinosum with occasional positivity in the superficial layer. Fibroblasts and endothelium of small vessels in the lamina propria showed MMP9 expression as well. In all cases of oral mucosal fibromas, the MMP -9 expression was seen only in fibroblasts and in endothelium of small vessels with occasional positivity within the overlying epithelium. it remains unclear, whether MMp -9 is directly connected to olp pathogenesis.

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“…Karatsaidis (2004) • Aumento de núcleos TUNEL+ de linfocitos T CD4 y CD68. Mazzarella (2006) • MMP-1 y 3 mayores en la forma erosiva respecto a la reticular . Karatsaidis (2003) • Ausencia de apoptosis.…”

Section: Estudio Clínico Resultadosunclassified

“…Sugieren que la alteración de la diferenciación de queratinocitos y/ o de su muerte celular programada sería la causa de la aparición de las lesiones de LPO. 17 (2006) sugieren la implicación de una familia de proteinasas zinc-dependientes, las metaloproteinasas de matriz (MMP), relacionadas con los procesos necesarios para la remodelación tisular, la curación de heridas y la invasión tumoral como son la angiogénesis, la migración celular y la activación proteolítica de factores de crecimiento. La actividad de las MMP se regula por los inhibidores endógenos tisulares de metaloproteinasas (TIMP), implicados por tanto en procesos como la proliferación y apoptosis celular y procesos angiogénicos e inflamatorios.…”

Section: Discussionunclassified

Apoptosis y liquen plano oral: Situación actual

Gil¹,

Flores²

2009

Av Odontoestomatol

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RESUMENEl liquen plano oral (LPO) es una enfermedad mucocutánea inflamatoria crónica, con una etiología aún desconocida, de base autoinmune, que suele cursar con manifestaciones orales, con una clínica e histología características y de curso evolutivo benigno, pero susceptible de transformación maligna. En los últimos años se ha investigado la relación entre su patogenia y los mecanismos apoptóticos de destrucción celular. Material y método: Búsqueda bibliográfica en el servidor de la U.S. National Library of Medicine and the National Institutes of Health (Pubmed) con las palabras clave "apoptosis AND oral lichen planus". Discusión: Existen diferentes estudios que evalúan la relación de los diferentes marcadores apoptóticos (TNF-α, bcl-2, Fas, p53, BMP-4, granzima B, MMP…) con la patogenia, evolución, clínica y malignización del LPO. Para la determinación de estos factores se emplean técnicas de anatomía patológica e inmunohistoquímica (TUNEL, PCR,…). Conclusión: no existe consenso en los resultados y las consiguientes conclusiones obtenidas en los diferentes estudios sobre la influencia de cada uno de los marcadores apoptóticos en el desarrollo de las lesiones de LPO. Es necesaria una mayor y más profunda investigación en búsqueda de un factor siempre asociado a las formas clínicas agresivas con mayor tendencia a la malignización.Palabras clave: Liquen plano oral, apoptosis, p53, Bcl-2, queratinocitos. SUMMARYOral lichen planus (OLP) is a mucocutaneous inflammatory chronic disease, with unknown etiology, autoinmune, usually associated with characteristical oral manifestations. Despite it has a benign evolution, is posible to become malign. Lately, relation between the pathogenesis and apoptotic cells destroy has been investigated. Methods: A bibliography survey was carried out with th U.S. National Library of Medicine and the National Institutes of Health (Pubmed) with the keywords "apoptosis AND oral lichen planus". Discussion: Several trials evaluate the relationship among several apoptotic markers (TNF-α, bcl-2, Fas, p53, BMP-4, granzyme B, MMP…) and OLP pathogenesis, evolution, clinic and malignization. These studies employed histology and immunohistochemistry (TUNEL, PCR) Conclusion: Lack of consensus on results and conclusions about the influence of each apoptotic marker in the OLP development. Further investigation is required to obtain an apoptotic marker strongly associated with aggressive clinic and high-risk of malignancy.

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Matrix metalloproteinase gene expression in oral lichen planus: erosive vs. reticular forms

Abstract: The different clinical appearances of OLP are associated with significant differences in MMP mRNA levels.

Cited by 39 publications

References 26 publications

Serum and Saliva MMP-3 in Patients with OLP and Oral SCC

Serum and Saliva MMP-3 in Patients with OLP and Oral SCC

Expression of Matrix Metalloproteinase 9 in Patients with Oral Lichen Planus

Apoptosis y liquen plano oral: Situación actual

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