Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are associated with gastric cancer risk in eastern Indian population

Dey, Sanjib; Stalin, Sami; Gupta, Akash; Saha, Debjit; Kesh, Kousik; Swarnakar, Snehasikta

doi:10.1002/mc.21837

Cited by 21 publications

(14 citation statements)

References 41 publications

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“…There are works of other researchers showing the association of this DNA locus and stomach cancer. For example, Dey et al [26] showed that genotypes rs3025058*6A/5A and rs3025058*5A/5A serve as a risk factor in relation to the development of gastroduodenal pathology.…”

Section: Discussionmentioning

confidence: 98%

Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development

et al. 2016

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Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP 1 (rs1799750, rs494379), MMP 2 (rs2285052), MMP 3 (rs3025058), MMP 9 (rs3918242, rs17576), and MMP 12 (rs2276109) and their tissue inhibitors TIMP 2 (rs8179090) and TIMP 3 (rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP 1, rs3025058 of gene MMP 3, rs3918242 and rs17576 of gene MMP 9, and rs9619311 of gene TIMP 3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.

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Section: Discussionmentioning

confidence: 98%

Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development

et al. 2016

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“…TIMPs-1 M M P s -1 ,2 ,3 ,7 , 9 ,1 0 ,1 2 ,1 3 ,1 4 T IM P s -1 ,2 ,3 M M P s -1 , 2 , 3 , 1 9 T I M P s -1 , 2 M M Ps -1 ,2 ,3 ,7, 9, 10 ,1 4, 15 ,1 9 TI M Ps -1 ,2 A n g io g e n e si s gastric cancer patients than in controls of eastern Indian population [66] . On contrary, only one study performed in Japanese population that showed higher incidents of colon cancer in individuals having 6A/6A genotype.…”

Section: Mmps Polymorphism In Tumor Formationmentioning

confidence: 95%

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Verma

Kesh

Ganguly

et al. 2014

WJBC

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teinase (TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK (reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2, -9 and -14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species (ROS) through mitochondrial dysfunction leading to altered protease/ anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. AbstractThe process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases (MMPs). Degradation of extracellular matrix (ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-

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“…25,26 MMP3 also has been implicated in various types of cancer. 42,43 The polymorphism rs2761887 in BMP4 presented an association trend with the most severe case of oral cleft: cleft lip with palate. We previously observed the association between the polymorphism rs17563 and oral cleft in a casecontrol design.…”

Section: Discussionmentioning

confidence: 99%

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

Sabóia¹,

Reis²,

Martins³

et al. 2015

Archives of Oral Biology

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Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are associated with gastric cancer risk in eastern Indian population

Cited by 21 publications

References 41 publications

Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development

Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

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