Matrix metalloproteinases degrade myelin basic protein

Chandler, Stephen F.; Coates, Rachael E.; Gearing, A. J. H.; Lury, Jon; Wells, Graham; Bone, Elisabeth A.

doi:10.1016/0304-3940(95)12173-0

Cited by 281 publications

(186 citation statements)

References 19 publications

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“…It is known to control the breakdown of MBP (Chandler et al, 1995), a late component of myelin formation that is produced by Schwann cells in injured peripheral nerve (Gupta et al, 1988;LeBlanc and Poduslo, 1990). While MMP-9-dependent degradation of MBP has been shown in models of multiple sclerosis (Gijbels et al, 1993;Proost et al, 1993) and cerebral ischemia (Asahi et al, 2001;Cho et al, 2006), this is the first demonstration of this relationship in the PNS.…”

Section: Discussionmentioning

confidence: 90%

Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve

Chattopadhyay

Myers

Janes

et al. 2007

Brain, Behavior, and Immunity

124

113

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Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced in Schwann cells hours after peripheral nerve injury and controls axonal degeneration and macrophage recruitment to the lesion. Here, we report a robust (90-fold) increase in MMP-9 mRNA within 24 h after rat sciatic nerve crush (1 to 60 days time-course). Using direct injection into a normal sciatic nerve, we identify the proinflammatory cytokines TNF-α and IL-1β as potent regulators of MMP-9 expression (Taqman qPCR, zymography). Myelinating Schwann cells produced MMP-9 in response to cytokine injection and crush nerve injury. MMP-9 gene deletion reduced unstimulated neuropathic nociceptive behavior after one week post-crush and preserved myelin thickness by protecting myelin basic protein (MBP) from degradation, tested by Western blot and immunofluorescence. These data suggest that MMP-9 expression in peripheral nerve is controlled by key proinflammatory cytokine pathways, and that its removal protects nerve fibers from demyelination and reduces neuropathic pain after injury.

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Section: Discussionmentioning

confidence: 90%

Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve

Chattopadhyay

Myers

Janes

et al. 2007

Brain, Behavior, and Immunity

124

113

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“…Interleukin receptor IL-2Rα no yes (Sheu et al, 2001) KiSS-1 protein/metastin yes yes (Takino et al, 2003) Kit-ligand yes (Heissig et al, 2002) Monocyte chemoattractant protein MCP-3 yes no (McQuibban et al, 2002) Monokine induced by interferon IFN-γ (MIG/CXCL -9) yes (Van den Myelin basic protein yes yes (Chandler et al, 1995) Myosin heavy chain yes yes (Rouet-Benzineb et al, 1999) Plasminogen yes yes (O'Reilly et al, 1999;Patterson and Sang, 1997) Platelet factor (PF)-4 yes…”

Section: (Van Den Steen Et Al 2003)mentioning

confidence: 99%

Gelatinase-mediated migration and invasion of cancer cells

Björklund

Koivunen

2005

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

465

609

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“…The main roles of MMPs in pathology include tissue destruction, fibrosis or may be expressed as weakening of ECM. For example, destruction of tissues is observed in cancer invasion and metastasis [22], rheumatoid arthritis and osteoarthritis [23,24], formation of decubitus and various ulcers [25], periodontal disease, brain injury [26] and neuroinflammatory diseases [27]. Fibrosis of tissues is characteristic for liver cirrhosis, fibrotic lung disease, otosclerosis, atherosclerosis, and multiple sclerosis [28].…”

Section: Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer

Groblewska

Siewko

Mroczko

et al. 2012

Folia Histochem Cytobiol.

173

108

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Esophageal cancer (EC) is one of the most aggressive malignant tumors of the gastrointestinal tract. There are two distinct histological types of EC: esophageal squamous cell carcinoma and adenocarcinoma of the esophagus. Etiologic factors and the patterns of incidence of both subtypes are different. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in esophageal carcinogenesis. Gellatinases MMP-2 and MMP-9 are able to degrade collagen IV from basement membranes and extracellular matrix which is related to tumor progression, including invasion, metastasis, growth and angiogenesis. It has been shown that increased expression of MMPs plays a crucial role in the development of several human malignancies, including esophageal cancer. The activity of MMPs is regulated by their endogenous natural inhibitors (TIMPs). Among these, the roles of TIMP-1 and TIMP-2 in EC development, tumor progression and formation of metastases have been most extensively characterized and best recognized.

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Matrix metalloproteinases degrade myelin basic protein

Cited by 281 publications

References 19 publications

Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve

Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve

Gelatinase-mediated migration and invasion of cancer cells

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer

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