Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression

Iizuka, Shinji; Ishimaru, Naozumi; Kudo, Yasusei

doi:10.3390/cancers6010396

Cited by 38 publications

(33 citation statements)

References 114 publications

(133 reference statements)

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“…50 Specifically, gene microarray-expression analysis in whole HNSCC-tumor samples detected overexpression of MMP1, -2, and -3, 51,52 whereas another comprehensive review indicated that MMP1, -3, -7, -10, -12, and -13 expressions were significantly increased in almost all investigated microarray data sets of HNSCC. 49 Immunohistochemical studies have also confirmed the results of microarray analysis. For example, Ye et al 53 detected upregulated expression of MMP1, -3, -7, -9, -10, -11, -12, and -13 in tongue squamous cell carcinoma (SCC).…”

Section: Mmps In Hnscc Mmp-expression Profile In Hnsccssupporting

confidence: 69%

“…The results of MMP geneexpression profiling recently carried out by Iizuka et al suggested that MMP1, -3, -7, -10, -12, and -13 expressions are significant prognostic markers for HNSCC tumorigenicity and malignant progression. 49 Earlier studies by Rosenthal and Matrisian proposed that MMP1, -2, -9, and -14 expression in HNSCC were related to disease progression. 50 Lotfi et al 58 investigated MMP2 and MMP9 serum levels in OSCC patients, and concluded that both were significantly elevated in OSCC patients compared with their healthy counterparts.…”

Section: Mmps As Tumor Biomarkersmentioning

confidence: 99%

“…49 MMP1, -2, -3, -7, -8, -9, -10, -11, -13, and -14 are most commonly noted to be overexpressed in head and neck cancers. 50 Specifically, gene microarray-expression analysis in whole HNSCC-tumor samples detected overexpression of MMP1, -2, and -3, 51,52 whereas another comprehensive review indicated that MMP1, -3, -7, -10, -12, and -13 expressions were significantly increased in almost all investigated microarray data sets of HNSCC.…”

Section: Mmps In Hnscc Mmp-expression Profile In Hnsccsmentioning

confidence: 99%

“…95 MMP1 induces epidermal hyperplasia and increases the susceptibility to tumorigenesis, invasion, and angiogenesis. 49 Since MMP3 is expressed by fibroblasts and tumor cells, it regulates cancer stem cells during tumor initiation and metastasis. 90 …”

Section: Mmps and Angiogenesismentioning

confidence: 99%

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Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated in numerous normal and pathologic processes, including uterine involution and organogenesis, inflammation and wound healing, vascular and autoimmune disease progression. Pertinent to this review, the role of MMPs in cancer biology is fairly well researched and documented, and remains a subject of continuing intense investigation. Not only are several MMPs overexpressed in head and neck squamous cell carcinomas (HNSCCs), expression has been correlated with salient tumorigenic hallmarks, such as cell proliferation, angiogenesis, invasion, and metastasis. The utility of changes in the expression profile, as well as various MMP polymorphisms as potential prognostic markers in oral cancers and oral premalignant lesions, have been investigated. Furthermore, the potential therapeutic utility of targeting MMPs in cancer remains attractive, although outcomes in this respect appear so far to be less encouraging with respect to HNSCCs. Because of the disappointing results observed in clinical trials where MMP-targeting regimens for HNSCCs utilized broad-spectrum small MMP catalytic site inhibitors, investigators now envision new strategies for MMP-specific targeting based on the recognition of new noncatalytic MMP domains with distinct functions. This review provides an overview of MMP activities in general and in cancers, and an update of their activities in HNSCC. Specifically, their role in the development and progression of HNSCC and their function as signaling molecules is discussed. Finally, their role as potential prognostic biomarkers and therapeutic targets in HNSCC is revisited.

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Section: Mmps In Hnscc Mmp-expression Profile In Hnsccssupporting

confidence: 69%

Section: Mmps As Tumor Biomarkersmentioning

confidence: 99%

Section: Mmps In Hnscc Mmp-expression Profile In Hnsccsmentioning

confidence: 99%

Section: Mmps and Angiogenesismentioning

confidence: 99%

See 2 more Smart Citations

Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

View full text Add to dashboard Cite

show abstract

“…Under physiological conditions, MMP expression is low in the majority of normal cells. By contrast, MMP expression is markedly increased in a number of different cancers (15,16) and is directly associated with tumor invasiveness (17), which contributes to poor patient outcomes. As two important members of the MMP family, MMP2 and MMP9 have been identified to be involved in colon cancer progression, hepatic metastasis (18), the promotion of lung cancer invasion (19), and hepatocellular carcinoma cell migration and invasion (20).…”

Section: Introductionmentioning

confidence: 99%

Securin promotes migration and invasion via matrix metalloproteinases in glioma cells

et al. 2015

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Abstract. Human securin, encoded by pituitary tumor transforming gene 1, is implicated in several oncogenic processes in the pathogenesis of brain tumors, including glioma. The aim of the present study was to examine the effect of securin on the migration and invasion of glioma cells. The results revealed that the overexpression of securin in glioma LN-229 cells significantly increased the invasion and transmigration abilities. By contrast, these abilities were significantly reduced by the downregulation of securin in glioma U373 cells. Furthermore, the results demonstrated that securin overexpression and downregulation significantly increased and decreased the levels of matrix metalloproteinase 2 and 9, respectively. These findings indicate a promotive role for securin in glioma migration and invasion, which may involve the action of matrix metalloproteinases.

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Development and Evaluation of Targeted Optical Imaging Probes for Image‐Guided Surgery in Head and Neck Cancer

et al. 2022

Advanced Therapeutics

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Head and neck cancer is the 7th most common cancer in the world and the primary treatment is surgical resection. Optical probes have shown great potential for application in image‐guided surgery to delineate tumor margins more accurately. Special biomarkers that are aberrant in tumors are considered in tumor‐targeting strategies. Targeted fluorescent probes can enable accurate visualization of tumor margins with appropriate targeting strategies, thereby providing better sensitivity and specificity. In this review, the preclinical evidence on optical probes that have been developed with specific targeting strategies is summarized and challenges in the clinical translation of novel targeted fluorescent probes are discussed.

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Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression

Cited by 38 publications

References 114 publications

Matrix metalloproteinases in head and neck cancer: current perspectives

Matrix metalloproteinases in head and neck cancer: current perspectives

Securin promotes migration and invasion via matrix metalloproteinases in glioma cells

Development and Evaluation of Targeted Optical Imaging Probes for Image‐Guided Surgery in Head and Neck Cancer

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