2023
DOI: 10.1182/bloodadvances.2022008680
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Matrix stiffness controls megakaryocyte adhesion, fibronectin fibrillogenesis, and proplatelet formation through Itgβ3

Abstract: Megakaryocytes are the precursor cells of platelets, located in the bone marrow. Once mature, they extend elongated projections named proplatelets through sinusoid vessels, emerging from the marrow stroma into the circulating blood. Not all signals from the microenvironment that regulate proplatelet formation are understood, particularly those from the bone marrow biomechanics. We sought here to investigate how megakaryocytes perceive and adapt to modifications of the stiffness of their environment. The bone m… Show more

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Cited by 5 publications
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