Maturation of human central auditory system activity: separating auditory evoked potentials by dipole source modeling

Ponton, Curtis W.; Eggermont, Jos J.; Khosla, Deepak; Kwong, Betty; Don, Manuel

doi:10.1016/s1388-2457(01)00733-7

Cited by 337 publications

(392 citation statements)

References 25 publications

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“…Controls: M100 latency for the group ranged from 100.8 to 166.1 ms and varied linearly in both 30 hemispheres, decreasing at a rate of 24 ms / year (LH) and 24.5 ms / year (RH). AD: M100 latency ranged from 116.2 to 186.2 ms. 31 Slopes of regression lines did not differ from zero in either LH or RH. M100 latency showed a tendency to vary with age in LH, 32 decreasing at a rate of 24.6 ms / year.…”

mentioning

confidence: 86%

Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation

Gage¹,

Siegel

Roberts³

2003

Developmental Brain Research

117

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mentioning

confidence: 86%

Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation

Gage¹,

Siegel

Roberts³

2003

Developmental Brain Research

117

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“…Previous studies have indicated that the N 1b /P 2 complex has a major contribution from a tangentially oriented source on the superior surface of the temporal lobe within the Sylvian fissure (Ponton et al 1993(Ponton et al , 2002Scherg and Von Cramon 1985), while the T-complex is possibly due to a laterally oriented source on the lateral surface of the temporal lobe (Tonnquist-Uhlen et al, in press). As shown in Figure 2, the temporal lobe is angled downward in the head.…”

Section: Dipole Source Analyses -Spatiotemporal Source Modelingmentioning

confidence: 99%

“…According to Scherg and Von Cramon (1985), the regional dipole model may be more appropriate for modeling neural activity generated in highly folded and functionally related cortical areas. Consistent with previous studies (Scherg and Von Cramon 1985;Ponton et al 1993Ponton et al , 2002, we used a pair of regional dipoles as the initial source model, with one dipole in each hemisphere, since afferents from each ear (i.e., each cochlear nucleus) are known to project both contralaterally and ipsilaterally. Figure 2 shows the bilaterally symmetrical regional dipole model used in the present study, with each regional dipole consisting of three mutually orthogonal dipoles oriented along the x, y, and z axes and sharing the same location.…”

Section: Dipole Source Analyses -Spatiotemporal Source Modelingmentioning

confidence: 99%

“…For this analysis, the electrical potentials evoked by brief click trains were subjected to dipole modeling techniques to estimate the underlying current generators of these potentials (Mosher et al 1992;Ponton et al 1993Ponton et al , 2002Scherg 1992). A mathematical model that describes the head as a 4-shell spherical volume conductor (Cuffin and Cohen 1979) and current sources as dipoles (Scherg and Von Cramon 1985;Snyder 1991) was used.…”

Section: Introductionmentioning

confidence: 99%

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Differential Ear Effects of Profound Unilateral Deafness on the Adult Human Central Auditory System

Khosla

Ponton

Eggermont

et al. 2003

JARO - Journal of the Association for Research in Otolaryngolog

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This study investigates the effects of profound acquired unilateral deafness on the adult human central auditory system by analyzing long-latency auditory evoked potentials (AEPs) with dipole source modeling methods. AEPs, elicited by clicks presented to the intact ear in 19 adult subjects with profound unilateral deafness and monaurally to each ear in eight adult normal-hearing controls, were recorded with a 31-channel system. The responses in the 70-210 ms time window, encompassing the N 1b /P 2 and Ta/Tb components of the AEPs, were modeled by a vertically and a laterally oriented dipole source in each hemisphere. Peak latencies and amplitudes of the major components of the dipole waveforms were measured in the hemispheres ipsilateral and contralateral to the stimulated ear. The normal-hearing subjects showed significant ipsilateral-contralateral latency and amplitude differences, with contralateral source activities that were typically larger and peaked earlier than the ipsilateral activities. In addition, the ipsilateralcontralateral amplitude differences from monaural presentation were similar for left and for right ear stimulation. For unilaterally deaf subjects, the previously reported reduction in ipsilateral-contralateral amplitude differences based on scalp waveforms was also observed in the dipole source waveforms. However, analysis of the source dipole activity demonstrated that the reduced inter-hemispheric amplitude differences were ear dependent. Specifically, these changes were found only in those subjects affected by profound left ear unilateral deafness.

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“…Two of these originate from auditory areas: The supra-temporal component, which exhibits a frontally negative peak and a positive peak at electrodes under the Sylvian-fissure when the EEG is recorded with a nose-reference, is well modeled by a tangential equivalent dipole placed in the supra-temporal cortex (Vaughan and Ritter, 1970). The T-complex (Wolpaw and Penry, 1975) is mainly observable at temporal sites, with a field well-described by radially oriented equivalent dipolar sources at the lateral sides of the temporal cortices, which may reflect activity in secondary auditory areas (Scherg and Von Cramon, 1986;Ponton et al, 2002). It has been suggested that P2 comprises at least two components as well (Verkindt et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Sound offset-related brain potentials show retained sensory processing, but increased cognitive control activity in older adults

Horváth

Gaál

Volosin

2017

Neurobiology of Aging

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This is the accepted version of Horváth, J., Gaál, Z. A., & Volosin, M. (2017). Sound offset-related brain potentials show retained sensory processing, but increased cognitive control activity in older adults. Neurobiology of Aging, 57,[232][233][234][235][236][237][238][239][240][241][242][243][244][245][246] AbstractIt has been hypothesized that age-related hearing loss is caused not only by peripheral, but also central changes in the auditory system. Many studies utilized event-related potentials (ERPs) elicited by sound onsets to characterize age-related differences in central auditory processing. Age-related ERP enhancements in such studies have often been interpreted in terms of elevated sensitivity to auditory stimulation. Such ERPs, however, comprise various components reflecting different aspects of auditory and task-related processing. The composition of the waveforms may considerably differ for ERPs elicited by other auditory events. In the present study ERPs elicited by tone-offsets were used to characterize processing differences between younger and older adults in a short-go, tone-duration discrimination paradigm. Whereas the onset-related auditory ERP was enhanced in the older adult group, no age-related differences were found in the offset-related auditory ERPs observable at temporal electrodes. In older adults, however, offset-related processing was dominated by an N2 that could reflect enhanced cognitive control activities. Because N2 was present regardless discrimination difficulty, younger adults may have framed the task as offset-detection, whereas older adults represented the task as "genuine" discrimination.

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Maturation of human central auditory system activity: separating auditory evoked potentials by dipole source modeling

Cited by 337 publications

References 25 publications

Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation

Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation

Differential Ear Effects of Profound Unilateral Deafness on the Adult Human Central Auditory System

Sound offset-related brain potentials show retained sensory processing, but increased cognitive control activity in older adults

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