Mature cystic teratoma coexisting with clear‐cell carcinoma in the ovary

Shimura, Koki; Matsumoto, Mariko; Sugahara, Takuya; Yamamoto, Takuro; Ogiso, Nozomi; Urata, Yoshishige; Okubo, Tomoharu

doi:10.1111/jog.13224

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…When malignant transformation of MCT is diagnosed, it is very important to determine whether the clear cell carcinoma coexists incidentally or that the clear cell carcinoma arises from MCT. So far, three cases of the coexistence of MCT and clear cell carcinoma have been reported [ 25 – 27 ]. However, in those reports, it is not pathologically proven that clear cell carcinomas have arisen from MCT.…”

Section: Discussionmentioning

confidence: 99%

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

et al. 2018

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BackgroundIt is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other types being exceptionally rare. We report an extremely rare case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma.Case presentationThe case was a 71-year-old woman with abdominal distention. Ultrasonography and magnetic resonance imaging showed a huge mass in her abdominal cavity. Fluorodeoxyglucose-positron emission tomography (FDG-PET) showed FDG uptake not only in the pelvic tumor but also in the hepatic nodule, thus suggesting metastases. We performed a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and an omentectomy. The pathological diagnosis showed clear cell carcinoma of the right ovary which arose from the MCT with malignant transformation pT2aNXM1. Although the patient underwent chemotherapy, she died after 17 months.ConclusionThis case is histologically characteristic of the proof of transition from simple squamous epithelium via simple glandular epithelium to papillary change with atypia. This is the first case report of unaccompanied clear cell carcinoma arising from MCT reported in English literatures.

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Section: Discussionmentioning

confidence: 99%

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

et al. 2018

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“…Squamous cell carcinoma is the most common malignant transformation in MCT (75% of cases) which are usually moderate to poorly differentiated [16] . Transformation of MCT to clear cell carcinoma is rare and to our knowledge only one case has been reported till now 10 , while three reports of coexistence of MCT and clear cell carcinoma are also there [9,11,12] . Clear cell carcinoma as we know histologically displays several patterns which often occur together.…”

Section: Case Reportmentioning

confidence: 99%

Malignant transformation of mature cystic teratoma an histological dilemma: Case report

Mohindroo¹,

Thakur²,

Mohindroo³

et al. 2022

Int. J. Clin. Diagn. Pathol.

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Malignant transformation of mature cystic teratoma is a rare phenomenon and often a diagnostic challenge. We present a case of a 42-year-old female presenting with abdominal distension. CECT abdomen revealed a solid cystic tubo-ovarian mass in pelvis which was then resected. On histopathological examination of the resected specimen a diagnosis of Malignant transformation of MCT with the possibility of malignant component to be Squamous cell carcinoma or Clear cell carcinoma was given. On Immunohistochemical evaluation the malignant component was confirmed to be Squamous cell carcinoma.

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“…Primary squamous cell carcinoma arising from endometriosis of ovary cases were excluded, and cases of malignant transformation from teratoma (endometrioid carcinoma or clear cell carcinoma) were also excluded. A total of three cases were found, and a case report was written in English [83]. The rest of cases were reported in Japanese and hence excluded [84,85].…”

Section: Recurrence and Malignant Transformationmentioning

confidence: 99%

“…The rest of cases were reported in Japanese and hence excluded [84,85]. Shimura et al [83] reported a 71-year-old patient who underwent surgery with a tumor up to 40 cm in the right ovary. The pathologic diagnosis was MCT, endometriotic cyst, clear cell carcinoma, clear cell adenofibroma, and clear cell borderline tumor.…”

Section: Recurrence and Malignant Transformationmentioning

confidence: 99%

Coexistence of mature cystic teratomas and endometriosis

Chae¹

2020

J. Mol. Clin. Med.

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Mature cystic ovarian teratomas are ovarian tumors that are most common in reproductive age women. MCTs are benign germ cell tumors that arise from totipotent germ cells in the ovary. Endometriosis is also a common gynecologic disease affecting reproductive age women. Endometriosis is a progressive and chronic disease associated with inflammation, chronic pelvic pain, and infertility. However, the pathophysiology, symptoms, diagnosis, and management of each disease are well known, but there is little information on the simultaneous occurrence of these two diseases. Therefore, the epidemiology, clinical symptoms, imaging, management, and the risk of malignant transformation of the coexistence of MCTs and endometriosis are discussed herein. PubMed and any reports of individuals with both MCTs and endometriosis were searched for all articles written in the English-language medical literature until May 2020. This review indicates that diagnosis and treatment of the coexistence of MCTs and endometriosis are more complicated when two diseases coexist than when only one disease exists. In conclusion, this comorbid conditions may not be as rare as it was previously thought. To understand and treat this complex condition, more studies are essential.

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Mature cystic teratoma coexisting with clear‐cell carcinoma in the ovary

Cited by 5 publications

References 7 publications

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

Malignant transformation of mature cystic teratoma an histological dilemma: Case report

Coexistence of mature cystic teratomas and endometriosis

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