1999
DOI: 10.1016/s0145-2126(99)00132-0
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Mature plasma cells as indicator of better prognosis in multiple myeloma. New methodology for the assessment of plasma cell morphology

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Cited by 49 publications
(52 citation statements)
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“…In addition, an association between plasma cell maturity and survival of patients with multiple myeloma has been recognized for >50 years (27). Subtypes defined by cytologic features have numbered between two and seven in various studies (9)(10)(11)(27)(28)(29)(30)(31) but can be generalized to three: (a) low grade/well differentiated/plasmacytic; (b) intermediate grade/plasmablastic; and (c) high grade/pleiomorphic/anaplastic. We adopted the plasmacytic, plasmablastic, anaplastic system to categorize mouse plasmacytomas.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, an association between plasma cell maturity and survival of patients with multiple myeloma has been recognized for >50 years (27). Subtypes defined by cytologic features have numbered between two and seven in various studies (9)(10)(11)(27)(28)(29)(30)(31) but can be generalized to three: (a) low grade/well differentiated/plasmacytic; (b) intermediate grade/plasmablastic; and (c) high grade/pleiomorphic/anaplastic. We adopted the plasmacytic, plasmablastic, anaplastic system to categorize mouse plasmacytomas.…”
Section: Resultsmentioning
confidence: 99%
“…On stained bone marrow aspirates, 100 plasma cells were classified according to Greipp et al 9 We subclassified the mature and the intermediate types as lymphoplasmacytic when more than 30% plasma cells were characterized by a less abundant cytoplasm; the nuclear-to-cytoplasm ratio was less than 0.6 according to Goasguen et al 10 Morphology was reviewed in a blind fashion by 2 of us (R.G. and R.B.).…”
Section: Morphologymentioning
confidence: 99%
“…At least 100 PC per slide were studied by each of them. Nucleus (49 mm) and nucleolus (42 mm) were considered as large and chromatin pattern was defined as dense clumped, dispersed heterogeneous or diffuse homogeneous according to Greipp et al 1 Reduced cytoplasm was considered when nuclearcytoplasmic (N/C) ratio exceeded 0.6 according to Goasguen et al 3 Definitions of mature PC (small nucleus with clumped chromatin), intermediate PC (large nucleus or nucleolus or dispersed chromatin), immature PC (diffuse chromatin) and plasmablasts (same as immature PC but with reduced cytoplasm) were derived from Greipp et al 1,4 Mature PC with reduced cytoplasm were distinguished and termed lymphoplasmacytoid PC (LP-PC), according to Hoyer et al 8 Concordance between observers was reached in 152 cases (85%) and in all 178 cases after simultaneous re-evaluation of the discordant slides on a multihead microscope. In 18 patients, plasmablasts (X2% of all PC) were initially observed by at least one of the observers.…”
Section: Morphological Studiesmentioning
confidence: 99%
“…Indeed, both immature and plasmablastic subtypes identified patients with a poor prognosis, while those with a mature morphology experienced better survival. [1][2][3][4] However, morphological definitions differ between studies, probably because of arbitrary criteria. Recently, some chromosomal abnormalities have been shown to be powerful prognostic factors, including the chromosome 13 abnormality (C13A) and recurrent 14q32 translocations.…”
Section: Introductionmentioning
confidence: 99%