“…It should be noted that, in addition to amoxicillin/clavulanate 1,4,7 and doxycycline, 38 practitioners have used perioperative amoxicillin, 2,3,36-38 clindamycin, 2,3,7,12,16 cephalosporins, 1,6,11 metronidazole, 12,16 tetracycline, 12,38 clarithromycin, 10 and levofloxacin 10 for SES or as treatment for postoperative sinus graft infection. For SES, perioperative antibiotics have been delivered locally, 3,16,38 orally, [1][2][3][4]6,7,[10][11][12]16,[36][37][38] or intravenously. 4,6,7,10 Although direct evidence to validate amoxicillin/clavulanate and doxycycline as optimal medications for antibiotic prophylaxis before SES does not exist, these agents are justified in the setting of SES based on established principles of anti-infective therapy, available data on the target microbial profile, and target bacteria antibiotic susceptibility.…”