Mayer wave activity in vasodepressor carotid sinus hypersensitivity

Finucane, Ciarán; Boyle, Gerry; Fan, Chie Wei; Hade, Dymphna; Byrne, Lisa; Kenny, Rose Anne

doi:10.1093/europace/eup385

Cited by 15 publications

(13 citation statements)

References 36 publications

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“…One candidate may be differences in autonomic function between such individuals. A recent report by our group shows that CSS is associated with enhanced resting sympathetic tone and baroreflex sensitivity [ 5 ], with similar results reported from observations of Meyer wave activity in the vasodepressor subtype of CSS [ 6 ]. In addition, neuropathological studies in patients with CSS have shown a high burden of hyperphosphorylated Tau protein in medullary autonomic nuclei associated with baroreflex activity [ 7 ].…”

Section: Introductionsupporting

confidence: 82%

Cardiac Iodine-123-Meta-Iodo-Benzylguanidine Uptake in Carotid Sinus Hypersensitivity

et al. 2015

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BackgroundCarotid sinus syndrome is the association of carotid sinus hypersensitivity with syncope, unexplained falls and drop attacks in generally older people. We evaluated cardiac sympathetic innervation in this disorder in individuals with carotid sinus syndrome, asymptomatic carotid sinus hypersensitivity and controls without carotid sinus hypersensitivity.MethodsConsecutive patients diagnosed with carotid sinus syndrome at a specialist falls and syncope unit were recruited. Asymptomatic carotid sinus hypersensitivity and non-carotid sinus hypersensitivity control participants recruited from a community-dwelling cohort. Cardiac sympathetic innervation was determined using Iodine-123-metaiodobenzylguanidine (123-I-MIBG) scanning. Heart to mediastinal uptake ratio (H:M) were determined for early and late uptake on planar scintigraphy at 20 minutes and 3 hours following intravenous injection of 123-I-MIBG.ResultsForty-two subjects: carotid sinus syndrome (n = 21), asymptomatic carotid sinus hypersensitivity (n = 12) and no carotid sinus hypersensitivity (n = 9) were included. Compared to the non- carotid sinus hypersensitivity control group, the carotid sinus syndrome group had significantly higher early H:M (estimated mean difference, B = 0.40; 95% confidence interval, CI = 0.13 to 0.67, p = 0.005) and late H:M (B = 0.32; 95%CI = 0.03 to 0.62, p = 0.032). There was, however, no significant difference in early H:M (p = 0.326) or late H:M (p = 0.351) between the asymptomatic carotid sinus hypersensitivity group and non- carotid sinus hypersensitivity controls.ConclusionsCardiac sympathetic neuronal activity is increased relative to age-matched controls in individuals with carotid sinus syndrome but not those with asymptomatic carotid sinus hypersensitivity. Blood pressure and heart rate measurements alone may therefore represent an over simplification in the assessment for carotid sinus syndrome and the relative increase in cardiac sympathetic innervation provides additional clues to understanding the mechanisms behind the symptomatic presentation of carotid sinus hypersensitivity.

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Section: Introductionsupporting

confidence: 82%

Cardiac Iodine-123-Meta-Iodo-Benzylguanidine Uptake in Carotid Sinus Hypersensitivity

et al. 2015

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“…Furthermore, recent studies have established the relationship between the breathing and that variation in the BP, identified as an independent risk factor for cardiovascular morbidity and mortality. 21,22 Along the same line, Funicane et al 23 argued that modulations of Mayer waves deeply influence blood pressure in vasodepressor carotid sinus hypersensitivity. 24 Accordingly, the measurement of these oscillations could be used as a tool for investigating underlying alterations in peripheral resistance regulatory mechanisms.…”

Section: Introductionmentioning

confidence: 92%

Modulated pressure waves in large elastic tubes

Yone¹,

Tabi²,

Mohamadou³

et al. 2013

Chaos

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Modulational instability is the direct way for the emergence of wave patterns and localized structures in nonlinear systems. We show in this work that it can be explored in the framework of blood flow models. The whole modified Navier-Stokes equations are reduced to a difference-differential amplitude equation. The modulational instability criterion is therefore derived from the latter, and unstable patterns occurrence is discussed on the basis of the nonlinear parameter model of the vessel. It is found that the critical amplitude is an increasing function of α, whereas the region of instability expands. The subsequent modulated pressure waves are obtained through numerical simulations, in agreement with our analytical expectations. Different classes of modulated pressure waves are obtained, and their close relationship with Mayer waves is discussed.

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“…Finally an association is reported between CSH and cardiovascular dysautonomia, witnessed by the changed baroreflex [19,20] and by the presence of orthostatic hypotension (OH). The matter of this link comes from patients studied with both MSC and tilt test.…”

Section: Chs and Dysautonomiamentioning

confidence: 99%

Carotid Sinus Hypersensibility: A Concept on the Way

Lagi¹

2013

IJCM

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This review examines the pathogenesis of Carotid Sinus Hypersensitivity (CSH) by describing the different hypotheses that exist in literature. One hypothesis is that CSH is not a disease of the heart but of the central and/or peripheral nervous system where the heart is the victim. CSH is associated with cognitive disturbance, vasovagal syncope and orthostatic hypotension. Another hypothesis is that the CSH is considered a syndrome or a symptom associated with different diseases so as to require a diagnostic framework. This Hypothesis is the basis of frequent recurrences that are associated with the pacemaker implant therapy only.

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Mayer wave activity in vasodepressor carotid sinus hypersensitivity

Abstract: Blood pressure variability in particular activity at Mayer wave frequencies was higher in VDCSH. Future work will investigate this approach as a basis for diagnosis of VDCSH, with implications for syncope and falls management.

Cited by 15 publications

References 36 publications

Cardiac Iodine-123-Meta-Iodo-Benzylguanidine Uptake in Carotid Sinus Hypersensitivity

Cardiac Iodine-123-Meta-Iodo-Benzylguanidine Uptake in Carotid Sinus Hypersensitivity

Modulated pressure waves in large elastic tubes

Carotid Sinus Hypersensibility: A Concept on the Way

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