MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus–related cervical cancer

Torque Teno Virus Viremia Load Size in Patients with Selected Congenital Defects of Innate Immunity

“…In conclusion, consistent with findings from other viral infections (4,6,8,10,12,(24)(25)(26), MBL2 polymorphisms known to lead to MBL deficiencies were associated with higher TTV VLs than was wild-type MBL2, supporting the view that innate immunity efficiency contributes to determining the TTV VL size. The increase was modest but might have been greater had we examined subjects earlier in infancy, when the role of MBL in antimicrobial resistance is most important (5,28).…”

“…MBL, encoded by gene MBL2 on chromosome 10, is a pattern recognition protein that exerts its protective action by activating the complement cascade through an antibody-independent pathway triggered by its binding to pathogen surfaces and other mechanisms (13). MBL is probably most important in antibacterial defenses (14) but also plays a significant role against viruses; indeed, MBL2 polymorphisms known to lead to lower-than-normal blood concentrations of functional MBL have been linked with an increased susceptibility to several enveloped and nonenveloped viruses (3,4,6,8,10,12,24,25,26). Furthermore, because the airways are colonized by TTV early in life and may represent a port of body entry (18), we conducted the investigation with patients being evaluated to confirm or exclude the presence of primary ciliary dyskinesia (PCD).…”

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

“…However, no statistically significant difference was found when stratifying the groups regarding MBL production, as previously reported [15,16]. Conversely, it has been reported that specific functional polymorphisms in the MBL2 gene could increase women's susceptibility to infection by high-risk HPV genotypes due to low MBL serum levels [14][15][16]. In addition, Zupin et al [24] suggested a possible association between MBL2 polymorphisms responsible for low MBL production and susceptibility to the development of atypical squamous cells of undetermined significance.…”

“…Conversely, higher levels of MBL could enhance tissue destruction due to unwarranted activation of complement [8,12]. In a few studies, an association between HPV and MBL has been reported [13][14][15][16]. Two of these studies [14][15][16] showed that certain polymorphisms in the MBL2 gene were associated with higher susceptibility to infection conferred by high-risk HPV genotypes, but another study [13] did not show any such association between MBL2 polymorphisms and HPV infection.…”

Níveis séricos e polimorfismos gênicos da Lectina Ligadora de Manose (MBL) e da Serino Protease Associada à MBP (MASP)-2 em uma amostra da população brasileira

“…Dermatite atópica Brandao et al, 2008b;Brandrup et al, 1999;Richardson et al, 1983 Aterosclerose Madsen et al, 1998b Diarréia crônica da infância Candy et al, 1980 Fibrose cística Garred et al, 1999b Doença pneumocócia invasiva Roy et al, 2002 Injúria de isquemia-reperfusão Collard et al, 2001 HIV Garred et al, 1997;Nielsen et al, 1995Malária Luty et al, 1998 Doença meningocócica Hibberd et al, 1999 Otite média Richardson et al, 1983 Abortos recorrentes Kilpatrick et al, 1995;Kruse et al, 2002 Artrite reumatóide Graudal et al, 1998;Saevarsdottir et al, 2001 Lúpus eritematoso sistêmico Garred et al, 2001 Hepatite viral Matsushita et al, 1998;Thomas et al, 1996 Imunodeficiência comum variável Mullighan et al, 2000 Dermatomiosite Werth et al, 2002 Doença pneumocócica invasiva Roy et al, 2002 Herpes vírus tipo 2 Gadjeva et al, 2004HPV Guimaraes et al, 2008Segat et al, 2009 Diabetes tipo 1 Brandao et al, 2008a Hepatite B Brown et al, 2007 Hepatite C Segat et al, 2007 Herpes simples-meningite Mollaret Tang et al, 2000 Doenças sem correlação com deficiência de MBL:…”