MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation

Luo, Yi Bo; Yu, Jun; Zhang, Qing; Lin, Fei; Wang, Zhongwei; Huang, Lin; Schatten, Heide; Sun, Qing‐Yuan

doi:10.4161/cc.24216

Cited by 24 publications

(21 citation statements)

References 44 publications

(42 reference statements)

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“…When microinjecting BrUTP into the GV oocytes, NSN oocytes showed a high level fluorescence, whereas the fluorescence in SN oocytes was not obvious, 3 indicating that the transcription in NSN oocytes was active but silenced in SN oocytes. Compared with SN oocytes, only 20-30% of the NSN oocytes were able to develop to the metaphase II stage and became mostly arrested at the 2-cell embryo stage after in vitro fertilization, 4 indicating low developmental competence of the NSN oocytes. Recent data showed that the configuration of chromatin in GV oocytes was controlled by histone modifications, 5 and the transcription silence of SN oocytes was controlled by the protein termed poly(rC) binding protein 1.…”

Section: Maternal Factors Required For Oocyte Developmental Competencmentioning

confidence: 95%

Maternal factors required for oocyte developmental competence in mice: Transcriptome analysis of non-surrounded nucleolus (NSN) and surrounded nucleolus (SN) oocytes

Luo

et al. 2013

Cell Cycle

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Section: Maternal Factors Required For Oocyte Developmental Competencmentioning

confidence: 95%

Maternal factors required for oocyte developmental competence in mice: Transcriptome analysis of non-surrounded nucleolus (NSN) and surrounded nucleolus (SN) oocytes

Luo

et al. 2013

Cell Cycle

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“…Six out of the 11 events in MDS-PGx are either out-of-frame or in-frame within a functional protein domain (Supplemental Table S14). Included in the 11 events that form the MDS-PGx are BCAS3, which is related to progression of other tumor types (Gururaj et al 2006), PROM1, which is involved in stem cell maintenance (Sompallae et al 2013), MBTD1 and CDCA2, which regulate chromosome structure, while CDCA2 also served as a prognostic marker for synovial sarcomas (Lagarde et al 2013;Luo et al 2013). ABI2 and TAF4B are known to regulate hematopoietic cell function (Dai and Pendergast 1995).…”

Section: Discussionmentioning

confidence: 99%

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators

Qiu

Zhou

Thol

et al. 2016

RNA

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Myelodysplastic syndromes (MDS) are heterogeneous myeloid disorders with prevalent mutations in several splicing factors, but the splicing programs linked to specific mutations or MDS in general remain to be systematically defined. We applied RASL-seq, a sensitive and cost-effective platform, to interrogate 5502 annotated splicing events in 169 samples from MDS patients or healthy individuals. We found that splicing signatures associated with normal hematopoietic lineages are largely related to cell signaling and differentiation programs, whereas MDS-linked signatures are primarily involved in cell cycle control and DNA damage responses. Despite the shared roles of affected splicing factors in the 3 ′ splice site definition, mutations in U2AF1, SRSF2, and SF3B1 affect divergent splicing programs, and interestingly, the affected genes fall into converging cancer-related pathways. A risk score derived from 11 splicing events appears to be independently associated with an MDS prognosis and AML transformation, suggesting potential clinical relevance of altered splicing patterns in MDS.

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“…[36] Figure 5 provides an illustrative view of the unique binding of UNC1215. [42] The PWWP domain The results of these experiments indicate that UNC1215 promotes dissociation of the GFP fusion protein from the chromatin, further suggesting that UNC1215 competes with cellular factors for binding of the MBT domains.…”

Section: The Mbt Domainmentioning

confidence: 93%

“…It was therefore concluded that MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation. [42] The PWWP domain…”

Section: The Mbt Domainmentioning

confidence: 99%

Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

et al. 2014

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Epigenetics is defined as the phenomenon of heritable phenotypic traits that are not governed by alteration of the genetic code. Major epigenetic control mechanisms include DNA methylation and post-translational modifications of histones, such as reversible histone acetylation and methylation of lysine residues. Methyllysine binding proteins recognize various levels of lysine methylation and mediate the signaling events that are induced by histone methylation. Therefore, they are also referred to as readers of the epigenetic code. In this article we review the current literature on the structure and biology of methyllysine binding proteins, especially with regard to their potential as drug targets. We also present the available inhibitors that block the interaction of methylated histones with their binding proteins.

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MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation

Cited by 24 publications

References 44 publications

Maternal factors required for oocyte developmental competence in mice: Transcriptome analysis of non-surrounded nucleolus (NSN) and surrounded nucleolus (SN) oocytes

Maternal factors required for oocyte developmental competence in mice: Transcriptome analysis of non-surrounded nucleolus (NSN) and surrounded nucleolus (SN) oocytes

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators

Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

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