“…ACTH also have extra adrenal functions and MC2R mRNA has been found in the brain and blood cells of mice and brain of fish ( Klovins et al, 2004 ; Nimura et al, 2006 ). In addition, MC2R is also expressed in the ovaries and testes of rainbow trout fish ( Aluru and Vijayan 2008 ) and in bovine ovary ( Etchevers et al, 2021 ). Therefore, the effect of ACTH on egg production may be mediated through its receptors in the ovaries; however, there is need for further research to confirm this prospect in birds.…”