MDM2 amplification in malignant Brenner tumors may play a role in progression to malignancy and aid in separation from urothelial and other ovarian carcinomas

Shetty, Sindhu; Habeeb, Omar; Rivera, Christine; Astbury, Caroline; Przybycin, Christopher G.; Joehlin‐Price, Amy

doi:10.1016/j.humpath.2021.08.001

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…It was previously demonstrated that the use of a platinum-based chemotherapeutic agent plus paclitaxel post-operatively improved patient survival (38). In the present study, it was indicated that MDM2 amplification was associated with MBT and that MDM2 may therefore be selected in the future as a drug target for patients with MBT (39).…”

Section: Discussionmentioning

confidence: 50%

Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review

Zou

Zhao³

et al. 2022

Oncol Lett

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Malignant Brenner tumor (MBT) of the ovary is a rare malignant ovarian tumor, whereas uterine corpus endometrioid carcinoma (UEC) constitutes one of the most common malignant tumors of the female reproductive system. The present study reported on a case of the coexistence of ovarian MBT and borderline mucinous cystadenoma combined with primary UEC. Therefore, the present case is a synchronous primary cancer of both ovary and endometrium. Although synchronous primary cancers of the endometrium and ovary are relatively uncommon, they are not rare; however, due to the rarity of MBT, this case was considered singular. To the best of our knowledge, this was the first-ever reported case of the coexistence of an ovarian MBT and borderline mucinous cystadenoma combined with primary UEC. Based on a review of the literature associated with the present case, its clinicopathological features, immunohistochemical phenotype, differential diagnosis, molecular changes, prognosis and treatment were summarized and discussed. The aim of the present study was to improve the understanding of this rare synchronous primary cancer of the ovary and endometrium so as to avoid future misdiagnosis.

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Section: Discussionmentioning

confidence: 50%

Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review

Zou

Zhao³

et al. 2022

Oncol Lett

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Ovarian Brenner Tumors and Other Rare Ovarian Tumors

Dibbern,

Jenkins

2024

Gynecologic and Obstetric Pathology

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Advances in diagnosis, clinical management and molecular characterization of ovarian Brenner tumors

Zanfagnin

Lee

Zhao

et al. 2023

gocm

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Brenner tumors is a very uncommon ovarian epithelial neoplasm, morphologically resembling the transitional cell neoplasm of urinary tract. It is further classified into three subtypes as a disease spectrum based on histological examination and tumorigenesis: benign Brenner tumors, borderline Brenner tumors (BBTs), and malignant Brenner tumors (MBTs). The etiology of these tumors is not well understood, and literature is limited due to the rarity of this entity, but recent advances, particularly in molecular alterations, have emerged. The scope of this review is to provide an update on the clinical, histopathological, and most recently, molecular characterizations of ovarian Brenner tumors.

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MDM2 amplification in malignant Brenner tumors may play a role in progression to malignancy and aid in separation from urothelial and other ovarian carcinomas

Cited by 4 publications

References 32 publications

Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review

Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review

Ovarian Brenner Tumors and Other Rare Ovarian Tumors

Advances in diagnosis, clinical management and molecular characterization of ovarian Brenner tumors

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