Mean corpuscular volume may be a useful index of risk for colorectal adenoma in middle-aged Japanese men

Fujimori, Shunji; Kishida, Teruyuki; Yonezawa, Masaoki; Shibata, Yoshiaki; Shinozawa, Isao; Tanaka, Shu; Hoshino, Testuo; Tatsuguchi, Atsushi; Sato, Jun; Yoshida, Yutaka; Yokoi, Kimiyoshi; Tanaka, Noritake; Ohaki, Yoshiharu; Sakamoto, Choitsu; Kobayashi, Masafumi

doi:10.1111/j.1572-0241.2000.01862.x

Cited by 6 publications

(6 citation statements)

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“…44 NSAIDs inhibit CRA progression through inflammatory factors. 45,46 Compared with research describing western populations that has shown significant associations between CRA occurrence and alcohol and cigarette consumption, [39][40][41]47 the current nonsignificant findings in a Chinese population might be the result of differences in alcohol and cigarette consumption compared with other populations. In the present study, the protective factors for CRA recurrence during follow-up were the same as for CRA occurrence (i.e.…”

Section: Discussioncontrasting

confidence: 58%

“…Alcohol is a known folate inhibitor that affects dietary methyl supply and therefore is associated with CRA and CRC. 39 – 41 In the present study, some factors were independent risk factors of CRA occurrence (age, BMI and family history of colorectal diseases), and two were independent protective factors (folic acid and a history of gastroenterology drug use). Visceral fat obesity has been confirmed as an independent risk factor for CRA, 42 which has been suggested to bring about its affects by increasing insulin-like growth factor 1, leading to the stimulation of colorectal epithelium proliferation.…”

Section: Discussionsupporting

confidence: 49%

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People with low serum folate levels have higher risk of colorectal adenoma/advanced colorectal adenoma occurrence and recurrence in China

et al. 2016

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ObjectiveTo investigate the potential association between serum folate levels and colorectal adenoma (CRA) occurrence and recurrence.MethodsThis prospective study measured baseline serum folate levels in outpatients who were screened for CRA using colonoscopy. Participants were then randomly selected to produce one group with CRA and one without CRA. These two subgroups underwent further follow-up observations of colonoscopy to determine the occurrence of new and recurrent CRA.ResultsA total of 1310 participants were screened at baseline: 888 were healthy subjects without CRA; and 422 had CRA. Two subgroups were randomly selected (n = 200 per group) for follow-up. In the overall population, baseline serum folate levels were significantly lower in patients with CRA or advanced CRA (A-CRA) compared with healthy participants without CRA. Similar findings were shown for the follow-up study in terms of the association between CRA and A-CRA occurrence and recurrence and baseline serum folate levels. After controlling for confounders, increased serum folate was associated with a reduced risk of occurrence of CRA (odds ratio [OR] 0.993, 95% confidence interval [CI] 0.924, 1.066) and recurrence of CRA (OR 0.749, 95% CI 0.322, 1.742).ConclusionsHigher serum folate levels may be protective against CRA and/or A-CRA.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionsupporting

confidence: 49%

People with low serum folate levels have higher risk of colorectal adenoma/advanced colorectal adenoma occurrence and recurrence in China

et al. 2016

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“…As a measure of the average volume of a red blood cell, mean corpuscular volume (MCV) was related to the prognosis of liver cancer ( 7 ), esophageal cancer ( 8 ) and adenocarcinomas of the gastroesophageal junction ( 9 ). Interestingly enough, MCV was also reported to be associated with the risk of colorectal adenoma ( 10 ), advanced CRC ( 11 ) and response to chemotherapy in CRC ( 12 , 13 ), suggesting MCV had the potential to be an ideal biomarker and be put into clinical application. In particular, previous study revealed that high MCV value may be used as an index of the risk of colorectal adenomas ( 10 ), but a recent research reported decreased MCV was an independent predictor for the detection of advanced colorectal cancer ( 11 ), indicating that the clinical role of MCV in colorectal cancer was still uncertain.…”

Section: Introductionmentioning

confidence: 99%

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Liu

Yang

et al. 2021

Front. Oncol.

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ObjectiveTo elucidate the prognostic significance of mean corpuscular volume (MCV), with implications of habitual alcohol intake in stage II-III colorectal cancer (CRC).BackgroundMCV had the potential to become an ideal prognostic biomarker and be put into clinical application. Few studies, however, have explored whether habitual alcohol intake which greatly increased the value of MCV would affect the prognostic role of MCV.MethodsEligible patients were identified from the CRC database of Fudan University Shanghai Cancer Center (FUSCC) between January 2012 and December 2013. Survival analyses were constructed using the Kaplan–Meier method to evaluate the survival time distribution, and the log-rank test was used to determine the survival differences. Univariate and multivariate Cox proportional hazard models were built to calculate the hazard ratios of different prognostic factors.ResultsA total of 694 patients diagnosed with stage II-III CRC between January 2012 and December 2013 were identified from FUSCC. Low pretreatment MCV was independently associated with 72.0% increased risk of overall mortality compared with normal MCV (HR = 1.720, 95%CI =1.028-2.876, P =0.039, using normal MCV as the reference). In patients with habitual alcohol intake, however, pretreatment MCV positively correlated with the mortality (P = 0.02) and tumor recurrence (P = 0.002) after adjusting for other known prognostic factors.ConclusionsIn CRC patients without habitual alcohol intake, low (<80 fL) level of pretreatment MCV was a predictor of poor prognosis. In patients with habitual alcohol intake, however, pretreatment MCV showed the opposite prognostic role, which would elicit many fundamental studies to elucidate the mechanisms behind.

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“…(mutation) (8-10), APC Mut. (11)(12)(13)(14), CRP (15)(16)(17)(18), CEA (18-23), CA 19-9 (18,22,24), WBC (25), MCV (26)(27)(28)(29), and mutation numbers in related genes were analyzed. In our study, 6384 patient data obtained from 22 articles were used.…”

Section: Resultsmentioning

confidence: 99%

Kolorektal Kanseri Teşhi̇s İçi̇n Yedi̇ Kan Bi̇yobeli̇rteçleri̇ Üzeri̇nde Karşilaştirmali Anali̇z

Bursalıoğlu¹

2020

Sağlık Bilimleri Dergisi

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Cancer has become one of the most important causes of mortality that human beings have faced in this century. Because the digestive system is a region where nutrients are involved and processed in the human body, colorectal cancer (CRC) has been increasing in recent years due to irregular and bad nutrition, stress, immobility and increased environmental pollution. Early detection has become one of the most important ways to stay alive in cancer. In recent years, artificial intelligence studies have begun to be used in the diagnosis and treatment of cancer. In this study, there is a search for early and practical diagnosis by analyzing some blood data acquisition related to colon cancer from different literatures together. Seven different biomarkers and blood-related gene data acquisition were used in the literature and WBC, CRP and CEA type may be used as biomarkers to diagnosis and follow-up for colorectal cancer.

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Mean corpuscular volume may be a useful index of risk for colorectal adenoma in middle-aged Japanese men

Abstract: A high MCV value may be used as a simple index of the risk of colorectal adenomas, regardless of alcohol consumption.

Cited by 6 publications

References 24 publications

People with low serum folate levels have higher risk of colorectal adenoma/advanced colorectal adenoma occurrence and recurrence in China

People with low serum folate levels have higher risk of colorectal adenoma/advanced colorectal adenoma occurrence and recurrence in China

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Kolorektal Kanseri Teşhi̇s İçi̇n Yedi̇ Kan Bi̇yobeli̇rteçleri̇ Üzeri̇nde Karşilaştirmali Anali̇z

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