Mean grey value is lower in endometriomas: Differentiating a hypoechogenic adnexal cyst by 3-dimensional power Doppler ultrasound—A preliminary study

Huang, Chen‐Yu; Wang, Hsing-I; Wang, Peng-Hui; Wu, Yu‐Chung; Yang, Ming-Jie; Chen, Li-Hsun; Chao, Kuan-Chong; Chen, Chih-Yao

doi:10.1016/j.jcma.2011.01.015

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…With regard to endometriosis, mean grayness has been used to differentiate endometriomas from other benign adnexal masses. Also, in this case, there have been discordant results, with Alcàzar et al observing an increase in the mean grayness index for endometriomas compared to other benign conditions and Huang et al stating contrary findings. Finally, in a recent study, Guerriero et al used mean grayness to identify the different locations of deeply infiltrating endometriosis based on the different constitutions of the tissue under investigation.…”

Section: Discussioncontrasting

confidence: 48%

Three‐Dimensional Power Doppler Vascularization in Women With Ovarian Endometriomas and Relationship With Associated Painful Symptoms

Rizzello

Capezzuoli

Scherbatoff

et al. 2017

J of Ultrasound Medicine

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Section: Discussioncontrasting

confidence: 48%

Three‐Dimensional Power Doppler Vascularization in Women With Ovarian Endometriomas and Relationship With Associated Painful Symptoms

Rizzello

Capezzuoli

Scherbatoff

et al. 2017

J of Ultrasound Medicine

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“…The VI, measuring the ratio of the number of colour voxels to the number of all voxels, is thought to represent the density of blood vessels (vascularity) and was expressed as a percentage (%) of the uterine volume. The VFI is a combination of vascularization and blood flow information; thus, it represents overall perfusion . The VFI refers to the weighted colour voxel/total voxel ratio, combining the information of vessel presence (vascularity) and amount of transported blood cells (blood flow).…”

Section: Methodsmentioning

confidence: 99%

Oestrogen‐induced angiogenesis promotes adenomyosis by activating the Slug‐VEGF axis in endometrial epithelial cells

Huang

Chen

Chou

et al. 2014

J Cellular Molecular Medi

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Adenomyosis is an oestrogen-dependent disease characterized by the invasion of endometrial epithelial cells into the myometrium of uterus, and angiogenesis is thought to be required for the implantation of endometrial glandular tissues during the adenomyotic pathogenesis. In this study, we demonstrate that compared with eutopic endometria, adenomyotic lesions exhibited increased vascularity as detected by sonography. Microscopically, the lesions also exhibited an oestrogen-associated elevation of microvascular density and VEGF expression in endometrial epithelial cells. We previously reported that oestrogen-induced Slug expression was critical for endometrial epithelial–mesenchymal transition and development of adenomyosis. Our present studies demonstrated that estradiol (E2) elicited a Slug-VEGF axis in endometrial epithelial cells, and also induced pro-angiogenic activity in vascular endothelial cells. The antagonizing agents against E2 or VEGF suppressed endothelial cells migration and tubal formation. Animal experiments furthermore confirmed that blockage of E2 or VEGF was efficient to attenuate the implantation of adenomyotic lesions. These results highlight the importance of oestrogen-induced angiogenesis in adenomyosis development and provide a potential strategy for treating adenomyosis through intercepting the E2-Slug-VEGF pathway.

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“…Likewise, Huang et al14 found no significant difference in VI, FI, or VFI between ovaries with endometriomas and other benign homogeneous hypoechogenic adnexal cysts. This goes to prove that endometriomas, like other benign cysts, do not alter ovarian stromal blood flow.…”

Section: Discussionmentioning

confidence: 93%

Effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women

El-Mazny

Kamel

Ramadan

et al. 2016

IJWH

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BackgroundAngiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women.Materials and methodsIn a case–control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility. In the mid-luteal (peri-implantation) phase of the cycle, endometrial thickness, uterine and ovarian artery pulsatility index and resistance index, endometrial and ovarian volume, 3-D power Doppler vascularization index (VI), flow index (FI), and vascularization FI (VFI) values were measured in both groups.ResultsThere were no significant differences (P>0.05) in endometrial thickness, uterine ovarian artery pulsatility index and resistance index, endometrial and ovarian volume, or VI, FI, and VFI between the two groups. Furthermore, the endometrial and ovarian Doppler indices were not influenced by endometrioma size. No significant differences were observed in the ovarian Doppler indices between endometrioma-containing ovaries and contralateral ovaries.ConclusionOvarian endometrioma is not associated with impaired endometrial and ovarian blood flows in infertile women scheduled for IVF, and it is not likely to affect endometrial receptivity or ovarian function through a vascular mechanism.

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Mean grey value is lower in endometriomas: Differentiating a hypoechogenic adnexal cyst by 3-dimensional power Doppler ultrasound—A preliminary study

Abstract: MGV might be useful to differentiate an endometrioma from other homogeneous hypoechogenic adnexal cysts.

Cited by 7 publications

References 23 publications

Three‐Dimensional Power Doppler Vascularization in Women With Ovarian Endometriomas and Relationship With Associated Painful Symptoms

Three‐Dimensional Power Doppler Vascularization in Women With Ovarian Endometriomas and Relationship With Associated Painful Symptoms

Oestrogen‐induced angiogenesis promotes adenomyosis by activating the Slug‐VEGF axis in endometrial epithelial cells

Effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women

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