Mean Platelet Volume: A Simple Tool For Early Risk Stratification Of Pulmonary Embolism

Şentürk, Ayşegül; Kanbay, Asiye; Erdoğan, Serpil; Hezer, Habibe; Hasanoğlu, H. Canan; Kılıç, Hatice; Öğüt, Tuba

doi:10.5505/ejm.2017.43534

Cited by 1 publication

(3 citation statements)

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“…A total of 2505 relevant publications were identified, and the screening process was done as shown in Figure 1 . Finally, 18 studies met the selection criteria and were included in the meta-analysis, with 14 studies on PE [ 3 , 14 , 22 – 33 ] and 7 studies on early death of patients due to PE [ 3 , 13 , 24 , 26 , 34 – 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…We identified studies by an in-depth search in 4 databases. Two additional study [ 14 , 30 ] on PE and 4 additional studies [ 13 , 34 – 36 ] on early death due to PE were included. The study by Farokhi M [ 47 ] on PE was excluded for abstract.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis on thrombosis and MPV published in 2017 reported that the onset of PE had no significant effect on the standardized mean difference (MD) of MPV between patients with PE and controls [ 12 ]. However, large sample studies on MPV and PE were subsequently conducted [ 13 , 14 ], and they showed a significant increase in MPV among patients with new PE onset and recurrent PE. A meta-analysis published in 2020 demonstrated an increased MPV associated with PE but not assessed the use of MPV as an indicator for the risk prediction and risk stratification of PE [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Lin

et al. 2021

Aging

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Platelet activation plays an important role in the progression of pulmonary embolism (PE). Mean platelet volume (MPV) can serve as a marker of platelet activity in patients with PE. Many studies have reported different results regarding the relationship. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the relationship between MPV and PE. Two reviewers independently searched relevant articles in databases from inception to April 21, 2021 and identified all studies on MPV and PE as the outcomes of interest. Further, we selected studies meeting the criteria and extracted the data. Of the 2505 publications identified, we included 18 studies after screening. Results showed MPV was significantly higher in patients with PE (0.83 fL, 95% CI: 0.38-1.28, P<0.001) than in controls. The mean difference in MPV between those who died and survivors of PE was 1.23 fL (95% CI: 0.96-1.51, P<0.001). Hence, an increased MPV is associated with PE. MPV could be a useful tool to predict the occurrence and death risk of PE together with other risk factors.

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