Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm

Varol, Ercan; Ozaydin, Mehmet; Türker, Yasin; Alaca, Sule

doi:10.1080/00365510903007000

Cited by 10 publications

(13 citation statements)

References 2 publications

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“…These thrombocytes express excessively PDGF, thromboxane A 2 , glycoprotein Ib and IIb/IIIa receptors. 10 The production of these substances increases thrombosis in patients with cancer and especially, high level of PDGF may promote tumor growth and invasion in malignancies. 11 In the literature, MPV was reported as a prognostic factor for different cancers.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Şehitoğlu

Bedir

Cüre

et al. 2016

An. Bras. Dermatol.

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Backgroundc-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter.ObjectiveTo investigate c-Kit expression and intensity in patients with Kaposi's sarcoma (KS) and to investigate the relation between Ki-67 proliferation and MPV.MethodsA total of 32 patients, diagnosed with classic cutaneous KS, were included in this study. We reevaluated the histopathological reports with the preparations, confirmed the diagnosis and then determined the patients' histopathological stages. c-Kit expression and Ki-67 proliferation were investigated immunohistochemically in KS cases, while MPV in all cases was checked.ResultsAlthough c-Kit expression was detected in 22 cases (68.8%), it was not expressed in 10 cases (31.2%). We detected 8 cases with + (25%), 6 with ++ (18.8%) and 8 with +++ (25%). Ki-67 expression was 5.0% (min-max 1.0-20.0). Relapse was observed in 5 cases (15.6%) out of 32. There was positive correlation between c-Kit expression and MPV (rs=0.598, p<0.001), and between c-Kit intensity and MPV (rs=0.588, p<0.001).Conclusionc-Kit is highly positive in KS. c-Kit positivity indicates a high risk of tumor growth, invasion and relapse. Furthermore, c-Kit expression stimulates megakaryocytes to release young and large thrombocytes into the periphery. Thus, high MPV, c-Kit expression and immunostaining intensity indicate high invasion and relapse in KS subjects.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Şehitoğlu

Bedir

Cüre

et al. 2016

An. Bras. Dermatol.

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“…It has been shown that the “giant platelets” have a higher enzymatic activity and produce more thromboxane A2 [14]. Also MPV is associated with myocardial infarction, acute cerebral ischemia and transient ischemic attack (TIA) [4, 15]. Increased values of MPV were observed in patients with mitral stenosis [16].…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume is elevated in patients with patent foramen ovale

Demir

Caglar

Ünğan

et al. 2013

aoms

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IntroductionPlatelets play a major role in thromboembolic events. Increased mean platelet volume (MPV) indicates higher platelet reactivity and also a tendency to thrombosis. Patent foramen ovale (PFO), persistence of the fetal anatomic shunt between right and left atria, is strongly associated with cryptogenic stroke. The aim of this study is to determine the relationship between MPV and PFO and if such an association exists, whether higher MPV levels may require antiplatelet therapy before a thromboembolic event happens, together with a literature review.Material and methodsThirty patients (15 women, 15 men), free of any cerebrovascular events, were diagnosed with PFO by transesophageal echocardiography (TEE), enrolled as the study group. Thirty consecutive patients (16 women and 14 men), who were diagnosed as normal in TEE, were enrolled as the control group. These two groups were compared according to MPV and anatomical features of the right atrium.ResultsThere was no significant difference between study and control groups in clinical features and also no difference was observed in platelet counts; however, MPV in the PFO group was significantly higher than the control group (8.38 ±0.93 fl and 7.45 ±0.68 fl respectively).ConclusionsOur results indicate that elevated MPV may be detected in patients with PFO. This might be one of the explanations for the relationship between PFO and cryptogenic stroke; however, larger cohorts are warranted in order to define further mechanisms.

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“…[4][5][6][7][8][9] An association between stenosis and platelet activation has been observed in other groups of valvular heart disease. Varol et al 24 showed that MPV was significantly elevated in patients with mitral stenosis and sinus rhythm compared to the controls. Mitral valve stenosis represents a relatively low-gradient stenosis, whereas AS is a high-gradient valvular defect.…”

Section: Discussionmentioning

confidence: 98%

Hematologic and Clinical Parameters After Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Aortic Stenosis

Gül

Uyarel

Akgül

et al. 2012

Clin Appl Thromb Hemost

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Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm

Cited by 10 publications

References 2 publications

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Mean platelet volume is elevated in patients with patent foramen ovale

Hematologic and Clinical Parameters After Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Aortic Stenosis

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