Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer’s disease

Liang, Qingcheng; Jin, Di; Li, Ying; Wang, Ruitao

doi:10.3109/09537104.2013.831064

Cited by 56 publications

(45 citation statements)

References 33 publications

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“…6 Moreover, platelets release more than 90% of circulating amyloid precursor protein (APP), which has been regarded as a diagnostic biomarker for AD. 13,14 The idea that AD is treated through the inhibition of pathologically excessive release of Aβ by platelets was suggested as an alternative therapeutic strategy. [10][11][12] Our previous reports confirmed that activated platelets, measured by mean platelet volume and platelet distribution width, are positively correlated with Mini-Mental State Examination (MMSE) score and have the potential to be used to differentiate between distinct dementia subtypes.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] Our previous reports confirmed that activated platelets, measured by mean platelet volume and platelet distribution width, are positively correlated with Mini-Mental State Examination (MMSE) score and have the potential to be used to differentiate between distinct dementia subtypes. 13,14 The idea that AD is treated through the inhibition of pathologically excessive release of Aβ by platelets was suggested as an alternative therapeutic strategy. 15 C-type lectin-like receptor 2 (CLEC-2), which belongs to a c-type lectin super family, is a receptor on the platelet surface and binds to a sialoglycoprotein, podoplanin.…”

Section: Introductionmentioning

confidence: 99%

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C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

et al. 2019

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Objective: Increased permeability and changes in gut microbiota contributed to the pathogenesis of Alzheimer's disease (AD). Zonulin is a key modulator that regulates intestinal barrier function. Peripheral platelet alterations have been involved in AD pathology. C-type lectin-like receptor 2 (CLEC-2) is a receptor on the platelet surface for activation. The purpose of this study was to determine zonulin and CLEC-2 levels in mild cognitive impairment (MCI) and AD, and investigate the relationship between zonulin and CLEC-2. Methods:In this study, CLEC-2 and zonulin levels were measured using ELISA assay in 110 AD patients, 110 MCI patients, and 110 non-demented control subjects.Results: Increased CLEC-2 and zonulin levels were observed in MCI and AD patients. Furthermore, AD patients had higher CLEC-2 and zonulin levels compared with MCI patients. In addition, CLEC-2 levels were positively correlated with zonulin levels, after adjusting confounding factors (r = .592, P < .001). Multivariate analysis revealed that increased CLEC-2 and zonulin levels were significantly associated with reduced Mini-Mental State Examination (MMSE) score.Conclusions: C-type lectin-like receptor 2 is correlated with zonulin after adjusting confounding covariates. Moreover, increased CLEC-2 and zonulin are the significant factors for reduced MMSE score in MCI and AD. Further studies are needed. K E Y W O R D SAlzheimer's disease, C-type lectin-like receptor 2, mild cognitive impairment, zonulin

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

et al. 2019

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“…Akarsu et al [35] found PDW levels were increased in neonatal sepsis. In contrast, Liang et al [36] found that PDW levels were significantly decreased in Alzheimer diseases. Topal et al [37] showed that PDW levels were decreased in atopic eczema.…”

Section: Discussionmentioning

confidence: 88%

Evaluation of Platelet Parameters in Children with Primary Epstein-Barr Virus Infection

Almis¹,

Bucak²,

Turğut³

2017

Ann Clin Anal Med

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Epstein-Barr virüs (EBV) herpes virüs ailesindendir. Çocuklarda yaşam boyu süren enfeksiyonlara ve birkaç kanser tipinin gelişmesinde rol oynamaktadır. Primer enfeksiyonu asemptomatik veya nonspesifik hafif bulgularla seyreder. Bu çalışmamızdaki amacımız primer EBV enfeksiyonlu hastalarda inflamatuvar sürecin trombosit parametrelerini, trombosit lenfosit oranını (TLO) ve nötrofil lenfosit oranını (NLO) etkileyip etkilemediğinin ortaya konulmasıdır. Gereç ve Yöntem: Çalışmamız retrospektif bir çalışma olup çalışmamıza 44 primer EBV enfeksiyonlu hasta ile 66 sağlıklı hasta dahil edildi. Her iki grubun demografik verileri ile laboratuvar bulguları kayıt edildi. Verilerin istatistiksel analizinde SPSS 22.0 programı kullanıldı. Niteliksel ve niceliksel verilerin analizinde Student's t-testi, Mann-Whitney U testi, ki kare testleri kullanıldı. İstatistiksel olarak anlamlılık için p < 0,05 değeri alındı. Bulgular: Ortalama trombosit sayısı, ortalama trombosit hacmi, albümin düzeyleri ve trombosit lenfosit oranı çalışma grubunda kontrol grubuna kıyasla anlamlı düzeyde düşük saptandı (p değerleri sırasıyla 0.028, 0.002, 0.012 ve <0.001'idi). Ortalama ürik asit düzeyi ile trombosit dağılım genişliği düzeyi ise çalışma grubunda kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek saptandı (p değerleri sırasıyla 0.007 ve <0.001 idi). Trombosit dağılım genişliği için 13,7 optimal cutoff düzeyi olarak alındığında [eğri altında kalan alan: 0,774] olup bu değer primer EBV enfeksiyonu için % 81 özgüllüğe, % 79,5 duyarlılığa sahipti (p< 0,001). Tartışma: Çalışmamız primer EBV enfeksiyonunun trombosit sayısı ve trombosit göstergelerini etkilediğini göstermesi açısından oldukça anlamlıdır. Trombosit parametrelerinin etkilendiği enfeksiyonlarda EBV, ilk düşünülmesi gereken viral etkenlerden biri olmalıdır. Trombosit göstergelerinin EBV enfeksiyonunda oynadığı rolü açıklayacak prospektif çalışmalara ihtiyaç vardır.

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“…PDW above 18% was described as increasing the risk of mortality [Guclu et al, 2013]. There are also studies reporting low PDW values [Liang et al, 2014;Huang et al, 2015]. PDW was significantly lower in the patient group compared to the control group on Alzheimer's disease and vascular dementia cases [Liang et al, 2014].…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever

Yılmaz

Menteşe

et al. 2016

J. Med. Virol.

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Platelet distribution width (PDW) is a readily available blood test involving calculations performed by automated blood analyzers. Crimean-Congo hemorrhagic fever (CCHF) may exhibit a severe profile with fatal hemorrhaging or else present with a mild clinical process. The purpose of our study was to investigate the importance of PDW in CCHF patients and its clinical prognostic value. This study was conducted with patients with CCHF. Patients were divided into two groups on the basis of presence or absence of bleeding. Demographic characteristics, clinical findings, PDW, and other laboratory tests were recorded onto forms. A total of 423 patients were included. Hemorrhaging was observed in 27.9% during hospitalization. PDW on the first day of hospitalization was 17.2 ± 0.9% in the hemorrhagic patients and 17.1 ± 0.6% in the cases without hemorrhage (P = 0.290). On the third day of hospitalization, PDW was 17.6 ± 0.8% in the hemorrhagic patients and 17.0 ± 0.7% in the cases without hemorrhage (P < 0.001). At a third-day PDW level cut-off point of 17.1%, AUROC was 0.677, sensitivity 65.5%, specificity 54.6%, PPV 35.5%, and NPV 80.6%. A one-unit raise in third day PDW stepped up the probability of bleeding in patients with CCHF 3.45-fold at logistic regression analysis. This study shows that PDW is a parameter that may be used to determine disease severity. This parameter may be at least as useful as platelet count in helping clinicians identify severe cases. Early identification of cases with a severe course will make it possible to provide early planning of modalities such as intensive care support. J. Med. Virol. 88:1862-1866, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer’s disease

Cited by 56 publications

References 33 publications

C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

Evaluation of Platelet Parameters in Children with Primary Epstein-Barr Virus Infection

Prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever

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