Mean platelet volume and platelet counts in type 2 Diabetes: Mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria

Abstract

IntroductionThe Mean platelet volume and platelet counts are indicators of thrombotic potentials, and risk factors for microvascular complications in diabetics. This study aimed to establish variations in platelet counts and mean platelet volume in type 2 diabetic patients on treatment and non-diabetic controls.MethodsThis was an unmatched case-control study involving 200 participants consisting of 100 diabetics and 100 non-diabetic controls. Four and half milliliters of blood was collected from diabetics and non diabetic controls into EDTA anticoagulant tubes. Full blood count was performed using the Sysmex KN-21N, (manufactured by Sysmex corporation Kobe, Japan) a three- part auto analyzer able to run 19 parameters per sample including platelet counts and mean platelet volume.ResultsThe mean fasting blood sugar for the diabetics was 147.85±72.54 mg/dl and the controls 95.20±30.10 mg/dl. The mean platelet count for the diabetics was 235.29±76.81*109/L and controls, 211.32±66.44*109/L. The mean platelet volume, for the diabetics was 8.69±0.67 fl and the controls, 8.91±0.80 fl. There was a statistically significant difference in platelet counts of diabetics and healthy controls p =0.038 while none existed between the mean platelet volume in diabetics and healthy controls p = 0.593.ConclusionThis study revealed a higher mean platelet count for diabetics on treatment than for non diabetic controls while mean platelet volume was lower in cases than controls. However, both parameters in diabetics on treatment were within the normal reference range for healthy individuals.

The markers of platelet functions and von willebrand factor serum content from patients with type 2 diabetes mellitus and ischemic stroke

“…So the overall mean platelet count for ischemic stroke was much lower of the control values. It is however in contrast to the findings of a ischemic stroke there were a lot of studies revealed a higher mean platelet count for diabetics than for the controls (Akinsegun et al, 2014). But our results showed the decrease of platelet count in patients with stroke complicated by type 2 diabetes, although this decrease was less than in case of stroke alone.…”

Association between mean platelet volume and hypertension incidence

“…Furthermore, platelet inhibitors such as aspirin have not been found to affect MPV. 16,17 Hypoglycemic or hypolipidemic decreases the MPV as well as plasma glucose level 18 or cholesterol levels. 19 Hundreds of participants of this study are taking hypoglycemic agent or hypolipidemic agent, may decrease the association between MPV and hypertension incidence, because individuals with diabetes or dyslipidemia have higher hypertension incidence even on treat.…”

Platelet count and mean platelet volume in the prediction of colorectal cancer in patients presented with emergency ileus

“…In a study where Karagöz et al and Pedersen et al searched platelet number in cases with lung cancer, they stated that platelet number in malignant cases was higher than those in healthy individuals [8][9][10][11][12][13][14][15][16][17][18][19] . In a research where Jun et al searched platelet parameters in middle age cancerous cases, MPV, platelet distribution is still diffi cult to diagnose intestine obstruction under emergency conditions in spite of up-to-date diagnostic and therapeutic modalities.…”