Mean platelet volume in patients with isolated coronary artery ectasia

Abstract

Coronary artery ectasia (CAE) is frequently considered to be an incidental angiographic finding; however, several reports have shown an association with myocardial ischemia and infarction. In this study, we aimed to evaluate the mean platelet volume (MPV), which is a marker of platelet reactivity, in patients with isolated CAE. In this study we investigated the platelet functions by MPV measurement in patients with isolated CAE. The study population consisted of 23 patients (17 males, 6 females) with isolated CAE (Group-I). Sex-age matched 30 patients (22 males, 8 females) with angiographically proven normal coronary arteries served as the control group (Group-II). Serum total cholesterol, HDL-C, LDL-C, triglyceride level, hemoglobin, white blood cell count, CRP, platelet count and MPV were compared in both groups. There was no significant difference between two groups in terms of age, gender, body mass index, blood pressure and heart rate. Serum total cholesterol, HDL-C, LDL-C, triglyceride level, hemoglobin, white blood cell count, platelet count were also similar in both groups. However, the MPV values of patients with isolated CAE were significantly higher than those of controls (P < 0.0001). In addition to that, CRP levels were found to be significantly higher in patients with isolated CAE (P < 0.002). Increased MPV may indicate the altered platelet reactivity and aggregation and thereby may be associated with ischemic events, observed in patients with isolated CAE.

Mean platelet volume in patients with coronary artery ectasia

“…We have also showed that the patients with CAE had a lower platelet count than in patients with controls in contrast to previous studies [16,17]. In these previous studies, the authors have found no significant difference in platelet count between CAE and control groups.…”

“…Recently published two studies [16,17] showed that MPV, another simple marker of platelet activation, was found to be elevated in patients with CAE compared with the control group.…”

“…Elevation of MPV values has been shown in atherosclerotic heart diseases, primarily acute MI [14,15]. Recently, MPV has been shown to be elevated in patients with CAE [16,17]. So, we aimed to investigate MPV values in patients with CAE with a larger group of population.…”

An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome

“…[22] Futhermore, Han et al [23] reported that MPV is a predictive marker for stroke or CAD, and Greisenegger et al [24] determined that an elevated MPV is associated with a poorer outcome for acute ischemic cerebrovascular events independent of other clinical parameters. Previous studies have also reported that high MPV levels are related with cardiovascular risk [25] and that these levels increase in patients with cardiac conditions [26][27][28] who have a poor prognosis.…”

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

“…Artan ekstrasellüler matriks yıkımı negatif remodeling ile sonuçlanır. PON aynı zamanda serbest radikallerin temizlenmesinde rol oynar ve bu radikallerin hücrenin yapısal komponentleri olan lipitler ve DNA üzerinde bulunan yapısal proteinlere vereceği zararı da azaltabilir (28)(29)(30)(31)(32)(33)(34). Pek çok yönden benzer bir patoloji olan aterosklerozun patogenezinde artan serbest radikallerin LDLK oksidasyonu yanın-da diğer hücresel komponentlere vermiş oldukları zarar da önem-lidir (28,35).…”