Mean platelet volume, in predicting severity of mitral regurgitation and left atrial appendage thrombosis

Ulu, Sena; Özkeçeci, Gülay; Akçi, Önder; Ahsen, Ahmet; Altug, Abdullah; Demir, Kasm; Acartürk, Gürsel

doi:10.1097/mbc.0b013e328364c453

Cited by 11 publications

(12 citation statements)

References 32 publications

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“… 5 MPV was considered as a quick and reliable guide in the assessment of LAS in patients with symptomatic atrial fibrillation patients 8 and primary mitral regurgitation. 23 A recent case-control study showed that a high MPV, with the cutoff value of >9.4 fl, is associated with an increased risk of stroke in AF patients. 24 Therefore, MPV was recommended to be added to the diagnostic criteria and risk stratification of AF.…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation

Liu¹,

Yu²,

Liang³

et al. 2023

IJGM

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Background The mean platelet volume to platelet count ratio (MPV/PC) has been investigated in the diagnosis, prognosis and risk stratification in several diseases. However, the predictive role of MPV/PC in left atrial stasis (LAS) of non-valvular atrial fibrillation (NVAF) patients remains unknown. Methods A total of 217 consecutive NVAF patients undergoing transesophageal echocardiogram (TEE) evaluation were retrospectively enrolled. The demographic, clinical, admission laboratory and TEE data were extracted and analyzed. Patients were categorized into those with or without LAS. The associations between the MPV/PC ratio and LAS were assessed by multivariate logistic regression analysis. Results There were 24.9% (n = 54) patients with LAS according to TEE. Compared with patients without LAS, the MPV/PC ratio was significantly higher in those with LAS (5.6±1.6 vs 4.8±1.0, P < 0.001). After multivariable adjustment, higher MPV/PC ratio levels (OR 1.747, 95% CI 1.193–2.559, P = 0.004) were positively associated with LAS, with the optimal cut-point for LAS prediction of 5.36 (area under the curve, AUC = 0.683, sensitivity 48%, specificity 73%, 95% CI 0.589–0.777, P < 0.001). The stratification analysis showed that a significant positive correlation between MPV/PC ratio ≥5.36 and LAS in patients of male, younger (<65 years), paroxysmal AF, without history of stroke/TIA, CHA 2 DS 2 -VASc score ≥2, left atrial diameter (LAD) ≥40mm and left atrial volume index (LAVI) >34mL/m 2 (all P < 0.05). Conclusion Increasing MPV/PC ratio was associated with an increased risk of LAS, which was mainly reflected in the subgroups of male, younger (<65 years), paroxysmal AF, without history of stroke/TIA, CHA 2 DS 2 -VASc score ≥2, LAD ≥40mm and LAVI >34mL/m 2 patients.

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Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation

Liu¹,

Yu²,

Liang³

et al. 2023

IJGM

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“…48 Mean platelet volume, which reflects the platelet production and function, is associated with MR severity and thromboembolism risk. 49,50 In terms of electrocardiographic markers, reduced LVEF, increased left atrial dimensions and left ventricular end diastolic diameter have been found to predict MR severity, which is associated with increased in-hospital cardiac death risk and overall mortality. 47,51,52 P wave indices reflective of left atrial remodeling, such as P wave area and P wave terminal force, was predictive of MR severity.…”

Section: Discussionmentioning

confidence: 99%

Predicting Stroke and Mortality in Mitral Regurgitation: A Machine Learning Approach

Zhou

Lee²,

Liu³

et al. 2023

Current Problems in Cardiology

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“…Thompson et al [ 63 ] found that large platelets have a greater coagulation capability than small platelets. Ulu et al [ 64 ] found that mean platelet volume (MPV) is associated with left ventricular thrombosis. In this instance, the MPV increased, which suggests platelet hyperfunction and necessitates further research on platelet activation status.…”

Section: Discussionmentioning

confidence: 99%

What is responsible for acute myocardial infarction in combination with aplastic anemia? A case report and literature review

Zhao¹,

Chen²,

Yan³

et al. 2022

World J Clin Cases

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BACKGROUND Aplastic anemia (AA) complicated with myocardial infarction (MI) is rare and associated with poor prognosis. Here, we present a case of AA with recurrent acute MI (AMI) in a patient treated with cyclosporine A (CsA) and stanozolol. In this patient, we suspect the long-term use of medication linked to platelets hyperfunction. CASE SUMMARY In 2017, a 45-year-old man was rushed to the emergency department of China-Japan Union Hospital due to precordial pain for 5 h. Based on his symptoms, medical history, blood tests, and findings from coronary angiography (CAG), the patient was diagnosed with acute anterior wall, ST-segment elevated MI, Killip II grade, AA, and dyslipidemia. In 2021, the patient was readmitted to the hospital for 2 h due to chest pain. Because the patient’s platelet count was 30 × 10 9 /L and he had severe thrombocytopenia, we performed CAG following platelet transfusion. Optical coherence tomography revealed lipid plaque and thrombus mass in his right coronary artery. The antithrombotic approach was adjusted to employ only anticoagulants (factor Xa inhibitors) and adenosine diphosphate inhibitors (clopidogrel) after assessing the risk of bleeding/thrombotic events. Long-term follow-up revealed that the patient had made a good recovery. CONCLUSION Patients with AA should be closely monitored for the risk of thrombosis and cardiovascular events, particularly when taking stanozolol or CsA for an extended period of time.

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Mean platelet volume, in predicting severity of mitral regurgitation and left atrial appendage thrombosis

Cited by 11 publications

References 32 publications

Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation

Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation

Predicting Stroke and Mortality in Mitral Regurgitation: A Machine Learning Approach

What is responsible for acute myocardial infarction in combination with aplastic anemia? A case report and literature review

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