Mean platelet volume in Type 2 diabetic patients

Hekimsoy, Zeliha; Payzın, Bahriye; Örnek, Talat; Kandoğan, Gülgün

doi:10.1016/s1056-8727(02)00282-9

Cited by 285 publications

(305 citation statements)

References 15 publications

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“…The mean age of the diabetic population was 54.89 ± 10.201 years whereas that of nondiabetic population was 45. (2,3,4,6,9,10) Higher values of MPV were observed in our study among the diabetic subjects with microvasular complications such as Retinopathy and Microalbuminuria which was statistically significant. Higher values were also seen in studies done by Papanas et al and Ates et al (9,10) This suggested a role for the increased platelet activity in the pathogenesis of vascular complications.…”

Section: Resultssupporting

confidence: 51%

“…Higher values were also seen in studies done by Papanas et al and Ates et al (9,10) This suggested a role for the increased platelet activity in the pathogenesis of vascular complications. On the contrary, in the studies done by Hekimsoy et al and Demirtunc et al, (3,6) MPV was not significantly different in subjects with diabetics complications. Their possible explanation was centered on the rapid consumption of activated platelets in diabetic without complications.…”

Section: Resultsmentioning

confidence: 68%

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Study on Mean Platelet Volume in Type 2 Diabetes Mellitus Patients vs Non Diabetic Patients

K¹

2017

jmscr

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Increased prevalence of vascular disease is seen in patients with Diabetes Mellitus (DM). Enhanced reactivity of platelets in patients with diabetes has been postulated to play a role in the microvascular and macrovascular complications of diabetes. MPV is being evaluated as a marker of increased platelet activation. This is a cross-sectional prospective study to evaluate MPV in patients with type 2 diabetes versus non-diabetic patients and to investigate the potential association between MPV and chronic diabetic complications. Our study revealed that MPV is increased in Diabetes mellitus (DM)

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Section: Resultssupporting

confidence: 51%

Section: Resultsmentioning

confidence: 68%

Study on Mean Platelet Volume in Type 2 Diabetes Mellitus Patients vs Non Diabetic Patients

K¹

2017

jmscr

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“…It was found to be significantly higher in patients with severe OSAS [5]. MPV may increase in other diseases such as hypercholesterolemia, diabetes mellitus, hypertension, ischemic stroke, myocardial infarction and smoking [6][7][8]. Red blood cell distribution width (RDW) is a laboratory measure of size variability and heterogeneity of erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Tapan¹,

Görgülü²,

Tertemiz³

et al. 2017

J Sleep Disord Ther

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In this study, we aimed to evaluate the effect of CPAP treatment on hemograms of patients with severe OSA in the lack of comorbidities which might affect the real values of hematological parameters.This retrospective cohort study patients selected from those whose polysomnography reports were compatible with severe OSAS and who underwent PAP titration in our sleep medicine department. 49 patients were enrolled to the study. The baseline hemograms of the participants were collected from one of the patients' visits before they started to use CPAP devices. The control hemograms were evaluated from one of the control visits in the first six months of treatment. We examined the red cell distribution width (RDW), mean platelet volume (MPV), hemotocrit (Hct) and platelet (Plt) count from the hemograms.The mean age was 58.2 years ± 11.3 years, 38.8% were female and 61.2% were male. 69.4% were non-smokers and 30.6% were ex-smokers. The mean body mass index (BMI) was 31.6 ± 5.8 while the mean apnea hypopnea index (AHI) was 50.2 ± 29. The mean duration of CPAP therapy was 4.8 months ± 3.3 months. The mean RDW, MPV, Hct and Plt count values before CPAP treatment were in normal ranges of laboratory tests. All of the values reduced after CPAP therapy but only the decrease in MPV was statistically significant.The reduced values supported that CPAP treatment helped to control hypercoagulability and prevented from cardiovascular disorders in OSAS. Hemogram may be a cheap and easily found laboratory test for monitoring the response to CPAP therapy.

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“…Large platelets express higher levels of prothrombotic substances, thromboxane A2, serotonin, b-thromboglobulin, and procoagulatory surface proteins, such as P-selectin and glycoprotein IIIa. [6,7] Increased MPV is associated with gestational diabetes mellitus, [8] congestive cardiac failure, [9] hypertension, [10] hypercholesterolemia, [11] and smoking. [12] Therefore, we excluded all patients having and of the above mentioned diseases to reduce the confounding effect in our statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

et al. 2012

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ÖZET Amaç Bu retrospektif çalışmanın amacı, ortalama tombosit hacmini, akut derin ven trombozlu (DVT) hastalarda ve kontrol grubunda karşılaş-tırmaktır. Gereç ve Yöntem SUMMARY ObjectivesThe purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. MethodsData were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. ResultsThere was no significant difference between the study and control groups in mean platelet volume (8.8±1.6 vs 8.7±1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. ConclusionsThere was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT.

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Mean platelet volume in Type 2 diabetic patients

Cited by 285 publications

References 15 publications

Study on Mean Platelet Volume in Type 2 Diabetes Mellitus Patients vs Non Diabetic Patients

Study on Mean Platelet Volume in Type 2 Diabetes Mellitus Patients vs Non Diabetic Patients

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

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