Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease

Abstract

Summary. After rupture of an arteriosclerotic plaque in a coronary artery, platelets play a crucial role in the subsequent thrombus formation, leading to myocardial infarction. An increased mean platelet volume (MPV), as an indicator of larger, more reactive platelets, may represent a risk factor for myocardial infarction. However, this hypothesis is still controversial and most studies addressing the role of MPV were performed comparing patients suffering from myocardial infarction with healthy controls. We intended to identify patients at high risk of suffering myocardial infarction in a group of patients with known coronary artery disease. One hundred and eighty-five consecutive patients with stable coronary artery disease were compared with 188 individuals who had suffered myocardial infarction. Patients within the highest quintile of MPV ( ‡ 11AE6 fl) had a significantly higher risk of experiencing a myocardial infarction compared with patients within the lowest quintile (OR ¼ 2AE6, 95% CI 1AE3-5AE1) in a multivariate analysis that included sex, age, body mass index, hyperlipidaemia, hypertension, smoking and diabetes mellitus. Our results indicate that patients with preexisting coronary artery disease and an increased MPV ( ‡ 11AE6 fl) are at higher risk of myocardial infarction. These patients can be easily identified during routine haematological analysis and could possibly benefit from preventive treatment.

Platelet reference ranges for neonates, defined using data from over 47 000 patients in a multihospital healthcare system

“…40 recently, the MPV has been the subject of significant research among adult patients with cardiovascular diseases, establishing that higher MPVs identify patients more likely to have poorer outcome after an acute vascular event. [43][44][45] It has been proposed in these patients that a larger MPV is an indicator of increased platelet activation. 46 The paucity of gestational age-based normative data has limited the clinical utility of MPVs in neonatal medicine.…”

Mean platelet volume does not predict risk of myocardial infarction or coronary artery disease in Indian patients

“…From earlier studies such as by Endler et al [1], we see that higher cut-off such as 11.6 have been used and this has been shown to be an independent risk factor. However in our observation we find that a very small number of patients had MPV values more than 11.…”

“…Significant risk factors such as diabetes, hypertension, smoking, hypercholesterolemia and lifestyle have been already studied. Mean platelet volume (MPV) has been found to be an independent risk factor in western populations and also from Indian Data [1][2][3]. Hence we thought it appropriate to look at this parameter in Indian patients with history of MI or CAD.…”

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

“…Large platelets have higher thrombotic potential [11] and express higher levels of P-selectin [12] and glycoprotein IIbIIIa [13] than small platelets. Several studies have shown increased MPV in patients with coronary artery disease [14,15], and MPV has been identified as an independent risk factor for myocardial infarction and stroke [16][17][18].…”