Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease

Abstract

Objective:Mean platelet volume (MPV) plays a pivotal role in the pathophysiology of atherosclerotic disease. Thoracic aortic intima-media thickness (IMT) was reported as an earlier marker of preclinical atherosclerosis than carotid IMT. However, the relationship between MPV and aortic IMT was not investigated. We aimed to assess the relationship between thoracic aortic IMT and MPV in patients undergoing transesophageal echocardiography (TEE) examination for different indications.Methods:We studied 190 patients (mean age 37.0±12.5 years) who underwent TEE for different indications. The patients who have known atherosclerotic disease were excluded from study. The patients were divided into 2 groups according to the median thoracic aortic IMT values (IMTlow group <13 mm and IMThigh group ≤13 mm). Platelet count and MPV were analyzed with an automated hematology analyzer. A multiple stepwise linear regression analysis was performed to identify the independent associations of thoracic aortic IMT.Results:The highest MPV values were observed in the IMThigh group compared with the IMTlow group (9.5±10 fL vs. 10.9±1.2 fL, p<0.001). Also, the IMThigh group had higher age, hs-CRP and uric acid levels (p<0.05 for all). Multiple linear regression analysis showed that aortic IMT was independently related with age (β=0.340, p<0.001), uric acid (β=0.111, p=0.041), hs-CRP (β=0.200, p<0.001), and MPV (β=0.482, p<0.001).Conclusion:MPV is independently related to the extent of subclinical thoracic aortic atherosclerosis. Increases in MPV may be a crucial biochemical marker for initial atherosclerosis.

An association of platelet indices with blood pressure in Beijing adults

“…Earlier findings have established that raised PDW and MPV levels are an independent risk factor for myocardial infarction including coronary heart diseases. [39–41] Increased platelet size is a risk factor for cardiovascular as well as diabetes and atherosclerosis disease, which have also been reported by some researchers, while increased MPV levels have shown in several inflammatory syndromes, such as, periodontitis, osteoarthritis and systemic sclerosis. [42,43] …”

Two-year prognostic value of mean platelet volume in patients with diabetes and stable coronary artery disease undergoing elective percutaneous coronary intervention

“…Previous studies have examined MPV in the development of CAD [3,[8][9][10]. MPV is an important factor for helping predict the prognosis of patients with CAD [6,[11][12][13].…”

Assessment of platelet reactivity after the anthracyclinebased chemotherapy via mean platelet volume: Does it act on anthracycline-induced cardiotoxicity?

“…Larger platelet size is associated with more platelet function and activation which plays a crucial role in the pathophysiology of atherosclerotic disease and ultimately long-term cardiotoxicity. Thrombocyte activation and aggregation leads to proliferation and migration of smooth muscle cells from the media to endothelium in early stages of atherogenesis [10][11][12]. In this regard, we aimed to study whether the anthracycline-based chemotherapy triggers a higher MPV that indicates the platelet activity.…”